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1.发明公开알파-일레오스테아르산을 포함하는 유방암 치료용 조성물및 이를 이용한 피피에이알γ 활성 조절에 의한 질환의치료방법 无效用于治疗包含ALPHA-ELEOSTEACIC酸的乳腺癌的组合物和通过使用其调节PPARγ活性来治疗疾病的方法
公开(公告)号：KR1020090012520A
公开(公告)日：2009-02-04
申请号：KR1020070076422
申请日：2007-07-30
Applicant: 재단법인서울대학교산학협력재단 , 주식회사 리포젠
Abstract: A composition for treatment of breast cancer is provided to investigate anti-cancer capability and mechanism in MCF-7 breast cancer cell using alpha-eleostearic acid. A composition for treatment of breast cancer includes alpha-eleostearic acid to active ingredient. A remedial method of disease at cancer cell line includes a step of processing the alpha-eleostearic acid of a therapeutically effective amount to the cancer cell line and prevents, suppresses or improves pathology or symptom of diseases by adjustment of PPAR gamma activity or phosphorylation of ERK1/2.
Abstract translation: 提供了一种用于治疗乳腺癌的组合物，用于研究使用α-蒿酸的MCF-7乳腺癌细胞的抗癌能力和机制。 用于治疗乳腺癌的组合物包括对活性成分的α-蒿酸。 在癌细胞系疾病的补救方法包括将治疗有效量的α-蒿酸处理至癌细胞系的步骤，通过调整PPARγ活性或ERK1磷酸化来预防，抑制或改善疾病的病理学或症状 / 2。
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2.发明公开피에이치 감응성과 점막점착성을 갖는 유드라지트로 코팅된단백질 경구투여용 키토산미립자 및 그 제조방법 无效用于通过敏感和不饱和脂肪族螺旋体衍生物涂覆的口服蛋白质药物递送的壳聚糖微球及其制备方法
公开(公告)号：KR1020090039513A
公开(公告)日：2009-04-22
申请号：KR1020070105205
申请日：2007-10-18
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: C08B37/003 , A61K9/0053 , A61K9/167 , A61K47/36
Abstract: A chitosan particle coated with thiolated eudragit, in which the BSA(Bovine Serum Albumin) is soaked, is provide to use as a delivery agent of a drug by oral administration. A manufacturing method of a chitosan particulate for a protein oral administration coated with eudragit having a pH sensitivity and mucous adhesive property comprises: a step of sonicating and centrifuging the chitosan solution to obtain chitosan particle; a step of adding BSA to the chiotsan particle, suspending to distribute the chitosan particle, and stirring at 35-40°C for 12-24 hours to soak the BSA into chitosan particle; and a step of adding the thiolated eudragit solution to the BSA-soaked chitosan particle, stirring and centrifuging to obtain the chitosan particle coated with BSA-dipped thiolated eudragit. The addition rate of the thiolated eudragit solution to the BSA-dipped chitosan particle is 1:1-1:4.
Abstract translation: 将BSA（牛血清白蛋白）浸泡的硫蛋白包被的壳聚糖颗粒通过口服给药用作药物的递送剂。 用于具有pH敏感性和粘性粘合性质的用于蛋白质口服给药的壳聚糖颗粒的制造方法包括：超声处理和离心壳聚糖溶液以获得壳聚糖颗粒的步骤; 将BSA加入到悬浮颗粒中，悬浮以分散壳聚糖颗粒，并在35-40℃下搅拌12-24小时以将BSA浸泡到壳聚糖颗粒中; 将硫醇化的eudragit溶液加入到BSA-浸泡的壳聚糖颗粒中，搅拌和离心以获得涂布有BSA-浸渍的硫苷酸脱乙酰壳多糖的壳聚糖颗粒的步骤。 硫苷酸脱乙酰壳多糖溶液对BSA-浸渍壳聚糖颗粒的添加速率为1:1-1:4。
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公开(公告)号：KR1020080029946A
公开(公告)日：2008-04-03
申请号：KR1020070098863
申请日：2007-10-01
Applicant: 재단법인서울대학교산학협력재단
IPC: A61K48/00 , C12N15/866 , A61K47/48 , A61P35/00
CPC classification number: A61K48/00 , A23V2200/308 , C12N15/866
Abstract: A novel viral gene carrier is provided to deliver a gene specifically to tumor cells by controlling the gene delivery efficiency with low cytotoxicity and high stability and having higher transduction efficiency to a receptor positive KB cell. A viral gene carrier is characterized in that it is prepared by modifying the surface of a recombinant baculovirus vector including a green fluorescent protein, luciferase or a PDCD4 (programmed cell death 4) gene using a folate-polyethylene glcyol conjugate. A method for preparing the viral gene carrier comprises the steps of: (a) preparing the recombinant baculovirus vector; (b) preparing the folate-polyethylene glycol conjugate; and (c) modifying the recombinant baculovirus vector surface with the folate-polyethylene glycol conjugate.
Abstract translation: 提供了一种新的病毒基因载体，通过以低细胞毒性和高稳定性控制基因传递效率并且对受体阳性KB细胞具有较高的转导效率，特异性地向肿瘤细胞递送基因。 病毒基因载体的特征在于其通过使用叶酸 - 聚乙烯胶体缀合物修饰包含绿色荧光蛋白，荧光素酶或PDCD4（程序性细胞死亡4）基因的重组杆状病毒载体的表面来制备。 制备病毒基因载体的方法包括以下步骤：（a）制备重组杆状病毒载体; （b）制备叶酸 - 聚乙二醇缀合物; 和（c）用叶酸 - 聚乙二醇缀合物修饰重组杆状病毒载体表面。
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4.发明公开
公开(公告)号：KR1020050055837A
公开(公告)日：2005-06-14
申请号：KR1020030088872
申请日：2003-12-09
Applicant: 재단법인서울대학교산학협력재단
IPC: A61K47/48
CPC classification number: A61K9/146 , A61K39/099 , A61K47/36 , A61K2039/552 , A61K2039/6087
Abstract: 본 발명은 보데텔라 브론키셉티카 데모네크로톡신 (
Bordetella bronchiseptica Dermonecrotoxin , BBD)이 담지된 키토산 미립자, 상기 키토산 미립자를 포함하는 돼지의 위축성 비염 예방용 백신 조성물 및 상기 백신 조성물의 돼지에의 투여방법에 관한 것이다. 본 발명의 백신 BBD가 담지된 키토산 미립자를 사용함으로써 독성 없이 저렴하게 돼지에서 위축성 비염에 대한 면역반응을 효과적으로 일으킬 수 있다.-
公开(公告)号：KR1020100001563A
公开(公告)日：2010-01-06
申请号：KR1020080061519
申请日：2008-06-27
Applicant: 재단법인서울대학교산학협력재단
Abstract: PURPOSE: A poly(ester amine)/DNA complex for non-viral DNA carrier is provided to ensure poly(ester amine)-controlled resolution, low cytotoxin, and high transfection efficiency, to be useful as an effective polymer carrier, and to exhibit big potential in intercellular gene transfer. CONSTITUTION: A method for manufacturing a poly(ester amine) polymer comprises the steps of: respectively dissolving glyceroldimethylacrylate or glyceroltrimethylacrylate and low molecular polyethylenimine (molecular weight 200-3,000) in methanol anhydride and then adding a glycerol dimethylacrylate solution to a polyethylenimine solution and mixing them; stirring and heating the mixed solution at 50-70 °C for 12-36 hours; dialyzing the mixture for 2-5 hours to 12-36 hours; and then lyophilizing the obtained polymer.
Abstract translation: 目的：提供用于非病毒DNA载体的聚（酯胺）/ DNA复合物，以确保聚（酯胺）控制的分辨率，低细胞毒素和高转染效率，可用作有效的聚合物载体，并显示 细胞间基因转移的巨大潜力。 构成：制备聚（酯胺）聚合物的方法包括以下步骤：分别将丙烯酸甘油酯二甲基丙烯酸酯或甘油三甲基丙烯酸酯和低分子量聚乙烯亚胺（分子量200-3,000）溶解在甲醇酐中，然后将甘油二甲基丙烯酸酯溶液加入到聚乙烯亚胺溶液中并混合 他们; 在50-70℃下搅拌和加热混合溶液12-36小时; 将混合物透析2-5小时至12-36小时; 然后将所得聚合物冻干。
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Patent Agency Ranking6.发明授权폴리카프로락톤 다이아크릴레이트와 폴리에틸렌이민을기초로 한 생분해성 폴리에스텔아민을 이용한 새로운유전자 전달체 失效一种基于聚己内酯二丙烯酸酯和聚乙烯亚胺作为基因载体的新型可生物降解聚酯胺
公开(公告)号：KR100860416B1
公开(公告)日：2008-09-26
申请号：KR1020060088277
申请日：2006-09-12
Applicant: 재단법인서울대학교산학협력재단
Abstract: 본 발명은 폴리카프로락톤 다이아크릴레이트와 폴리에틸렌이민을 기초로 한 생분해성 폴리에스텔아민으로 구성된 유전자 전달체에 관한 것이다. 더욱 상세하게는 본 발명은 폴리카프로락톤 다이아크릴레이트와 폴리에틸렌이민을 기초로 한 생분해성 폴리에스텔아민으로 구성된 유전자전달체로써 낮은 세포독성, 생분해성 및 높은 유전자 전달효율로 유전자를 효율적으로 전달하는 뛰어난 효과가 있다.
유전자전달체, 생분해성, 폴리에스텔아민, 폴리카프로락톤 다이아크릴레이트, 폴리에틸렌이민-
公开(公告)号：KR1020070109411A
公开(公告)日：2007-11-15
申请号：KR1020060042330
申请日：2006-05-11
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61K47/61 , A61K9/0043 , A61K47/60 , A61K47/6925 , Y10S424/825
Abstract: 본발명은안정제로서폴리에테르를함유하고, 보데텔라브론키셉티카데모네크로톡신(, BBD)이담지된키토산미립자, 상기키토산미립자를포함하는돼지의위축성비염예방용백신조성물및 상기백신조성물의돼지에의투여방법에관한것이다. 본발명은폴리에테르를함유하고 BBD가담지된키토산미립자를사용함으로써전신성(systemic)면역반응과점막면역반응을효과적으로유도할수 있으므로, 본발명의폴리에테르가함유된키토산미립자는비강백신접종을위한잠재력있는면역보조제임을알 수있다.
Abstract translation: 提供壳聚糖微球以防止壳聚糖微球聚集在一起并保持疫苗活性，即使其通过包含聚醚作为稳定剂长时间保存，从而用作鼻内疫苗接种的潜在免疫补充剂 。 含有支气管炎博德特氏菌脱氧皮质激素（BBD）的壳聚糖微球包含0.5-20重量％的作为稳定剂的聚醚和40-70重量％的分子量为5-1000K的壳聚糖。 微球的尺寸在0.5-100微米的范围内。 用于预防猪萎缩性鼻炎的疫苗组合物包含壳聚糖微球。
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公开(公告)号：KR1020070029982A
公开(公告)日：2007-03-15
申请号：KR1020050084679
申请日：2005-09-12
Applicant: 재단법인서울대학교산학협력재단
IPC: C08B37/08
CPC classification number: A61K48/00 , C08B37/00 , C08L5/08 , C12N2501/2312
Abstract: A mannosylated chitosan derivative and a gene delivery system using the same are provided to overcome the disadvantages in an existing viral gene delivery system and to show cell specificity and gene expression with high efficiency. The mannosylated chitosan derivative as a polymer compound has a main repeating unit represented by the formula, wherein n>x and n is an integer of 1 and more, and preferably has a molecular weight of 5K-1,000K. The gene delivery system comprises the above mannosylated chitosan derivative. The mannosylated chitosan derivative is conjugated with DNA to form a complex which is useful for the treatment of a gene-related disease such as a genetic disease, an immune disease and cancer.
Abstract translation: 提供了甘露糖基化的壳聚糖衍生物和使用其的基因递送系统以克服现有病毒基因递送系统中的缺点并以高效率显示细胞特异性和基因表达。 作为高分子化合物的甘露糖基化壳聚糖衍生物具有下式所示的主要重复单元，其中n> x和n是1以上的整数，优选分子量为5K-1,000K。 基因递送系统包含上述甘露糖基化壳聚糖衍生物。 甘露糖基化的壳聚糖衍生物与DNA缀合以形成可用于治疗基因相关疾病如遗传疾病，免疫疾病和癌症的复合物。
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公开(公告)号：KR100980395B1
公开(公告)日：2010-09-07
申请号：KR1020080061519
申请日：2008-06-27
Applicant: 재단법인서울대학교산학협력재단
Abstract: 본 발명은 글리세롤 디메틸아크릴레이트 및 저분자량 폴리에틸렌이민으로 합성되어 세포독성이 없고 트렌스펙션 효율이 높은 폴리(에스테르 아민) 중합체, 및 상기 중합체를 담체로하여 제조된 비-바이러스성 유전자 전달체인 중합체/DNA 복합체에 관한 것으로, 본 발명에 따른 비-바이러스성 유전자 전달체인 PEA/DNA 복합체는, PEA가 조절된 분해능, 현저히 낮은 세포독성 및 높은 트랜스펙션 효율을 제공할 수 있어 효과적인 유전자 전달체용 담체로서 사용할 수 있어, 세포내 유전자 전달에 있어 큰 잠재력을 발휘하는 효과가 있다.
유전자 전달체, PEA, PEI, 트렌스펙션-
公开(公告)号：KR100919731B1
公开(公告)日：2009-09-29
申请号：KR1020060042330
申请日：2006-05-11
Applicant: 재단법인서울대학교산학협력재단
Abstract: 본발명은안정제로서폴리에테르를함유하고, 보데텔라브론키셉티카데모네크로톡신(, BBD)이담지된키토산미립자, 상기키토산미립자를포함하는돼지의위축성비염예방용백신조성물및 상기백신조성물의돼지에의투여방법에관한것이다. 본발명은폴리에테르를함유하고 BBD가담지된키토산미립자를사용함으로써전신성(systemic)면역반응과점막면역반응을효과적으로유도할수 있으므로, 본발명의폴리에테르가함유된키토산미립자는비강백신접종을위한잠재력있는면역보조제임을알 수있다.
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