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公开(公告)号：KR100891373B1
公开(公告)日：2009-04-02
申请号：KR1020070042611
申请日：2007-05-02
Applicant: 재단법인서울대학교산학협력재단 , 주프로스테믹스
IPC: C08B37/08
CPC classification number: C08B37/0072 , A61K35/30 , A61K35/32 , A61K35/34 , A61K35/545 , C08J9/28 , C08J2201/026 , C08J2201/0484 , C08J2205/022 , C08J2305/08 , C12N5/0068 , C12N2533/80 , C12N2537/00 , C12N2537/10
Abstract: Provided is a preparation method of a porous hyaluronic acid sponge comprising the steps of: dissolving hyaluronic acid in an aqueous sodium hydroxide solution; adding an epoxy-based crosslinking agent to the resultant aqueous sodium hydroxide solution in which hyaluronic acid is dissolved and homogenizing the hyaluronic acid solution; hydrogelating the homogenized hyaluronic acid solution; washing the hydrogelated hyaluronic acid hydrogel with ultrapure water; swelling the washed hyaluronic acid hydrogel to attain porosity; and freeze-drying the hyaluronic acid hydrogel to obtain a porous hyaluronic acid sponge.
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公开(公告)号：KR1020070108062A
公开(公告)日：2007-11-08
申请号：KR1020070042611
申请日：2007-05-02
Applicant: 재단법인서울대학교산학협력재단 , 주프로스테믹스
IPC: C08B37/08
CPC classification number: C08B37/0072 , A61K35/30 , A61K35/32 , A61K35/34 , A61K35/545 , C08J9/28 , C08J2201/026 , C08J2201/0484 , C08J2205/022 , C08J2305/08 , C12N5/0068 , C12N2533/80 , C12N2537/00 , C12N2537/10
Abstract: A method for preparing a porous hyaluronic acid sponge for a cell delivery system is provided to produce a porous hyaluronic acid sponge capable of controlling pore size thereof so as to cultivate cells well. A method for preparing a porous hyaluronic acid sponge includes the steps of: (S101) dissolving a hyaluronic acid in an aqueous sodium hydroxide solution; (S102) adding an epoxy-based crosslinking agent to the aqueous sodium hydroxide solution containing hyaluronic acid, and then homogenizing the obtained hyaluronic acid solution; (S103) hydrogelling the homogenized hyaluronic acid solution; (S104) washing the hyaluronic acid hydrogel with ultrapure water; (S105) swelling the washed hyaluronic acid hydrogel to acquire porosity; and (S106) freeze-drying the hyaluronic acid hydrogel to obtain a porous hyaluronic acid sponge.
Abstract translation: 提供了一种制备用于细胞递送系统的多孔透明质酸海绵的方法，以制备能够控制其孔径以便良好培养细胞的多孔透明质酸海绵。 制备多孔透明质酸海绵的方法包括以下步骤：（S101）将透明质酸溶解在氢氧化钠水溶液中; （S102）向含有透明质酸的氢氧化钠水溶液中添加环氧类交联剂，然后均化所得透明质酸溶液; （S103）使匀化的透明质酸溶液水凝; （S104）用超纯水洗涤透明质酸水凝胶; （S105）溶解洗涤后的透明质酸水凝胶以获得孔隙度; 和（S106）冷冻干燥透明质酸水凝胶，得到多孔透明质酸海绵。
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公开(公告)号：KR1020090119428A
公开(公告)日：2009-11-19
申请号：KR1020080045474
申请日：2008-05-16
Applicant: 주프로스테믹스
Abstract: PURPOSE: A pharmaceutical composition for curing scar containing culture of adult stem cell or its fraction is provided to promote division and proliferation of skin cell. CONSTITUTION: A pharmaceutical composition for curing scar contains culture of adult stem cell or its fraction as active ingredient. The culture of adult stem cell is supernatant obtained by centrifuging culture medium, concentrate or freeze-dried material of the supernatant. The culture medium of adult stem cell is obtained by sub-culturing adult stem cell in serum medium then culturing in serum free medium. The serum medium is DMEM(Dulbecco's Modified Eagle Medium) containing 1-2 mM of glutamine, 0.5-1 mM of sodium pyruvate, 0.1-10% FBS, 1% of antibiotics and 1-4.5 g/L of glucose.
Abstract translation: 目的：提供一种用于治疗含有成体干细胞培养的瘢痕或其部分的药物组合物，以促进皮肤细胞的分裂和增殖。 构成：用于治疗瘢痕的药物组合物含有成体干细胞或其部分作为活性成分的培养物。 成体干细胞的培养是通过离心上清液的培养基，浓缩物或冷冻干燥物质获得的上清液。 通过在血清培养基中培养成体干细胞，然后在无血清培养基中培养，获得成体干细胞的培养基。 血清培养基是含有1-2mM谷氨酰胺，0.5-1mM丙酮酸钠，0.1-10％FBS，1％抗生素和1-4.5g / L葡萄糖的DMEM（Dulbecco's Modified Eagle培养基）。
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Patent Agency Ranking
公开(公告)号：KR100848056B1
公开(公告)日：2008-07-23
申请号：KR1020070076221
申请日：2007-07-30
Abstract: A cosmetic composition comprising the cultured medium of adult stem cells is provided to inhibit synthesis of melanin and activity of tyrosinase without side effects, so that the composition is useful for whitening the skin. A cosmetic composition for whitening the skin comprises the cultured medium of adult stem cells derived from mammals, especially adipocytes, bone marrow tissue and umbilical cord blood of mammals or proteins separated from the cultured medium, wherein the adult stem cell is isolated from adipocytes by obtaining fat tissue through liposuction, treating the extracellular matrix of fat tissue with collagenase, centrifuging the enzyme-treated product to divide the enzyme-treated product into monocytes, hematocytes and several cell debris.
Abstract translation: 提供包含成体干细胞的培养基的化妆品组合物，以抑制黑色素的合成和酪氨酸酶的活性而没有副作用，使得该组合物可用于使皮肤美白。 用于使皮肤美白的化妆品组合物包含哺乳动物，特别是脂肪细胞，骨髓组织和来自培养基的蛋白质分离的骨髓组织和脐带血的成体干细胞的培养基，其中通过获得成体干细胞从脂肪细胞分离 通过脂肪抽吸脂肪组织，用胶原酶处理脂肪组织的细胞外基质，离心酶处理产物以将酶处理的产物分成单核细胞，血细胞和几个细胞碎片。
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公开(公告)号：KR1020090111121A
公开(公告)日：2009-10-26
申请号：KR1020080036725
申请日：2008-04-21
Applicant: 주프로스테믹스
IPC: A61K35/28 , C12N5/0775 , A61K8/98
CPC classification number: A61K35/28 , A61K8/981 , C12N5/0667 , C12N2500/99
Abstract: PURPOSE: A composition for preventing or treating atopic dermatitis is provided to minimize immunological rejection by having active protein complex. CONSTITUTION: A composition for preventing or treating atopic dermatitis contains adult stem cell culture medium or its fraction as an active ingredient. The adult stem cell culture medium is supernatant, concentrate of the supernatant or freeze drive material of the supernatant. The supernatant is obtained by centrifuging the adult stem cell culture medium.
Abstract translation: 目的：提供用于预防或治疗特应性皮炎的组合物，以通过具有活性蛋白复合物来最大限度地减少免疫排斥反应。 构成：用于预防或治疗特应性皮炎的组合物含有成体干细胞培养基或其部分作为活性成分。 成体干细胞培养基是上清液，上清浓缩物或上清液的冷冻驱动材料。 通过离心成体干细胞培养基获得上清液。
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公开(公告)号：KR100925341B1
公开(公告)日：2009-11-09
申请号：KR1020080036725
申请日：2008-04-21
Applicant: 주프로스테믹스
IPC: A61K35/28 , C12N5/0775 , A61K8/98
Abstract: 본 발명은 성체 줄기세포의 배양물 또는 그의 분획물을 유효성분으로 포함하는, 아토피성 피부염(atopic dermatitis)의 예방 또는 치료용 약학 조성물을 제공한다. 또한, 본 발명은 성체 줄기세포의 배양물 또는 그의 분획물을 포함하는, 아토피성 피부염의 개선 또는 증상완화용 화장료 조성물을 제공한다.
상기 성체 줄기세포의 배양물 또는 그의 분획물은 피부 보호막 소실과 이로 인한 2차 감염을 억제하고 피부 보호막을 유지시킴으로써, 아토피성 피부염을 예방하거나 치료하는데 사용될 수 있다. 특히 본 발명의 조성물은 줄기세포가 아닌 줄기세포가 분비하는 활성 단백질 복합물을 함유함으로써, 줄기세포를 사용할 때 나타날 수 있는 면역학적 거부 반응을 최소화할 수 있다.
성체 줄기세포, 아토피성 피부염-
公开(公告)号：KR101454840B1
公开(公告)日：2014-10-28
申请号：KR1020080047498
申请日：2008-05-22
Applicant: 주프로스테믹스
CPC classification number: A61K38/02
Abstract: 본 발명은 성체 줄기세포의 배양물 또는 그의 분획물을 유효성분으로 포함하는, 암 예방 또는 치료용 약학 조성물을 제공한다.
상기 성체 줄기세포의 배양물 또는 그의 분획물, 특히 성체 줄기세포 배양물의 특정 분획물은 흑색종, 췌장암, 유방암, 간암, 위암, 대장암, 폐암, 자궁경부암 등을 비롯한 다양한 암의 증식을 억제함으로써, 우수한 암 예방 및 치료 활성을 갖는다. 본 발명의 조성물은 줄기세포가 아닌 줄기세포가 분비하는 활성 단백질 복합물을 함유함으로써, 줄기세포를 사용할 때 나타날 수 있는 제제학적 문제점이나 개체편차를 최소화할 수 있다. 또한, 인체 내 세포 주입으로 인하여 발생할 수 있는 부작용을 근본적으로 방지할 수 있다.
항암, 줄기세포-
公开(公告)号：KR1020090121541A
公开(公告)日：2009-11-26
申请号：KR1020080047498
申请日：2008-05-22
Applicant: 주프로스테믹스
Abstract: PURPOSE: A pharmaceutical composition for preventing or treating cancer, which contains culture medium of adult stem cell or its fraction is provided to minimize problem of stem cells and prevent side effects caused by injection of stem cells into the human body. CONSTITUTION: A pharmaceutical composition for preventing or treating contains culture of adult stem cells or its fraction as an active ingredient. The culture of adult stem cells is supernatant obtained by centrifuging, concentrate of the supernatant or freeze-dried product of the supernatant. A culture medium of the adult stem cells is obtained through sub-culture of the adult stem cell in serum medium then culturing in serum-free medium. The serum medium is DMEM containing 1-2 Mm glutamine, 0,5-1 mM sodium pyruvate, 0.1-10% of FBS, 1% of antibiotics(100 IU/ml), and 1-4.5 g/L of glucose. The serum-free medium is mixture medium of DMEM and Ham's F-12.
Abstract translation: 目的：提供一种用于预防或治疗癌症的药物组合物，其含有成体干细胞或其部分的培养基，以使干细胞的问题最小化并防止由干细胞注入人体引起的副作用。 构成：用于预防或治疗的药物组合物含有成体干细胞或其部分作为活性成分的培养物。 成体干细胞的培养是通过离心，浓缩上清液或上清液的冷冻干燥产物获得的上清液。 通过在血清培养基中培养成体干细胞，然后在无血清培养基中培养成体干细胞的培养基。 血清培养基是含有1-2Mm谷氨酰胺，0.5-1mM丙酮酸钠，0.1-10％FBS，1％抗生素（100IU / ml）和1-4.5g / L葡萄糖的DMEM。 无血清培养基是DMEM和Ham's F-12的混合培养基。
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