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公开(公告)号：KR100741867B1
公开(公告)日：2007-07-24
申请号：KR1020050060438
申请日：2005-07-05
Applicant: 전북대학교산학협력단
Abstract: 본 발명은 수중유적 및 용매 증발법을 이용한 이중층 미립구의 제조방법에 관한 것으로서, 더욱 상세하게는 비점이 낮은 유기용매에 용해된 생분해성 고분자의 분산상과 수용성 고분자의 분산매를 이용한 수중유적 공정을 수행한 다음, 이를 장시간의 물리적 교반에 의해 상기 낮은 비점의 유기용매를 증발시켜 석출하는 일련의 공정으로, 내부에 친수성의 수용성 고분자층과 외부에 소수성의 생분해성 고분자층의 이중 구조를 갖는 미립구의 형성이 가능할 뿐만 아니라 종래에 비해 외부와 내부의 붕괴를 막아 형성된 이중층의 유지가 용이하고, 공정이 단순화되어 경제성이 향상된 수중유적 및 용매 증발법을 이용하여 이중층 미립구를 제조하는 방법에 관한 것이다.
생분해성 고분자, 수용성 고분자, 수중유적, 용매 증발법, 이중층 미립구-
公开(公告)号：KR100744833B1
公开(公告)日：2007-08-01
申请号：KR1020060018402
申请日：2006-02-24
Applicant: 전북대학교산학협력단
Abstract: An artificial intervertebral disc comprising a disc cell and a method of regenerating a tissue engineered disc using the same disc cell are provided to regenerate a disc using an artificial disc comprising a scaffold having the inside and outside comprising different component. An artificial intervertebral disc comprising a disc cell includes: an inside disc including a disc central shaft in a disc shape and comprising biodegradable porous scaffold including nucleus pulposus cells; and an outside disc surrounding the inside disc in a doughnut shape, and comprising biodegradable porous scaffold including annulus fibrous cells. The artificial intervertebral disc further includes a natural or synthetic biomaterial added to the biodegradable porous scaffold of the inside or the outside of the disc.
Abstract translation: 提供一种包括椎间盘细胞的人造椎间盘和使用相同椎间盘细胞再生组织工程椎间盘的方法，以使用包括内部和外部包含不同组分的支架的人造椎间盘再生椎间盘。 包括椎间盘细胞的人造椎间盘包括：内椎间盘，所述内椎间盘包括椎间盘中心轴并且包括包括髓核细胞的生物可降解多孔支架; 以及环形内圆盘的外圆盘，其为圆环形，并且包括包含环形纤维细胞的可生物降解的多孔支架。 人造椎间盘还包括添加到盘内部或外部的生物可降解多孔支架的天然或合成生物材料。
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公开(公告)号：KR1020070005239A
公开(公告)日：2007-01-10
申请号：KR1020050060438
申请日：2005-07-05
Applicant: 전북대학교산학협력단
CPC classification number: A61K9/5089 , A61K9/5031 , A61K9/5042 , A61K9/5078 , A61K9/5084
Abstract: A preparation method of double-layered sphere by using oil-in-water and solvent evaporation is provided to prepare double-layered sphere containing an interior hydrophilic water-soluble polymer layer and an exterior hydrophobic biodegradable polymer layer, improve stability of sphere by inhibiting collapse of the sphere, and simplify the preparation procedures. The preparation method of double-layered sphere comprises the steps of: dissolving 0.005-0.3 parts by weight of biodegradable polymer in 1 part by weight of organic solvent boiling at 35-45 deg.C to prepare the dispersion phase; dissolving 0.01-0.06 parts by weight of surfactant and 0.01-0.05 parts by weight of water-soluble polymer in 1 part by weight of water so as to prepare the dispersion medium; and adding dropwise of the dispersion phase into the dispersion medium, and stirring the mixture at 300-1500 rpm for 7 to 15 hours, wherein the biodegradable polymer is polylactide, polyglycolide, poly(lactide-glycolide) copolymer, polycaprolactone, polyorthoester, polyiminocarbonate, polyanhydride, polyethyl glutamate or polydioxanone; the organic solvent is methylene chloride, hexa fluoroisopropanol, acetone, tetrahydrofuran, ethylacetate or chloroform; and the diameter of the double-layered sphere is 400nm-500mum.
Abstract translation: 提供了一种通过使用水包油和溶剂蒸发的双层球的制备方法，以制备含有亲水亲水性水溶性聚合物层和外部疏水性生物可降解聚合物层的双层球体，通过抑制塌陷来提高球体的稳定性 的范围，并简化了准备程序。 双层球体的制备方法包括以下步骤：将0.005-0.3重量份可生物降解的聚合物溶解在1重量份在35-45℃沸腾的有机溶剂中以制备分散相; 将0.01-0.06重量份的表面活性剂和0.01-0.05重量份的水溶性聚合物溶解在1重量份的水中以制备分散介质; 并将分散相滴加到分散介质中，并以300-1500rpm搅拌混合物7至15小时，其中可生物降解的聚合物是聚丙交酯，聚乙交酯，聚（丙交酯 - 乙交酯）共聚物，聚己内酯，聚原酸酯，聚亚油酸酯， 聚酐，聚乙酸谷氨酸酯或聚二恶烷酮; 有机溶剂是二氯甲烷，六氟异丙醇，丙酮，四氢呋喃，乙酸乙酯或氯仿; 双层球体的直径为400nm-500μm。
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