公开(公告)号：KR100744833B1

公开(公告)日：2007-08-01

申请号：KR1020060018402

申请日：2006-02-24

Applicant: 전북대학교산학협력단

Inventor： 강길선 ,  박기숙 ,  김순희 ,  고종태 ,  최방실 ,  하현정 ,  고연경 ,  윤선중

IPC: A61F2/44 ,  A61F2/30 ,  A61F2/28 ,  A61F2/02

Abstract: An artificial intervertebral disc comprising a disc cell and a method of regenerating a tissue engineered disc using the same disc cell are provided to regenerate a disc using an artificial disc comprising a scaffold having the inside and outside comprising different component. An artificial intervertebral disc comprising a disc cell includes: an inside disc including a disc central shaft in a disc shape and comprising biodegradable porous scaffold including nucleus pulposus cells; and an outside disc surrounding the inside disc in a doughnut shape, and comprising biodegradable porous scaffold including annulus fibrous cells. The artificial intervertebral disc further includes a natural or synthetic biomaterial added to the biodegradable porous scaffold of the inside or the outside of the disc.

Abstract translation: 提供一种包括椎间盘细胞的人造椎间盘和使用相同椎间盘细胞再生组织工程椎间盘的方法，以使用包括内部和外部包含不同组分的支架的人造椎间盘再生椎间盘。 包括椎间盘细胞的人造椎间盘包括：内椎间盘，所述内椎间盘包括椎间盘中心轴并且包括包括髓核细胞的生物可降解多孔支架; 以及环形内圆盘的外圆盘，其为圆环形，并且包括包含环形纤维细胞的可生物降解的多孔支架。 人造椎间盘还包括添加到盘内部或外部的生物可降解多孔支架的天然或合成生物材料。

公开(公告)号：KR1020090075503A

公开(公告)日：2009-07-08

申请号：KR1020080001380

申请日：2008-01-04

Applicant: 전북대학교산학협력단

Inventor： 강길선 ,  고연경 ,  김순희 ,  임지예

IPC: A61L27/44 ,  A61L27/40 ,  A61L27/56 ,  A61L27/20 ,  A61L27/14 ,  A61L27/22 ,  A61L27/24 ,  A61L27/26

CPC classification number: A61L27/44 ,  A61L27/14 ,  A61L27/20 ,  A61L27/222 ,  A61L27/24 ,  A61L27/26 ,  A61L27/40 ,  A61L27/56

Abstract: A method for manufacturing biodegradable porous hybrid carrier and an artificial organ are provided, which obtain the environment that cell can adhere and increase. A method for manufacturing biodegradable porous hybrid carrier comprises a step for injecting the mixture prepared by adding hyaluronic acid solution 10-50 volume% to organic solvent 50-90 volume% containing the biodegradable polymer for providing the bio-compatibility and the vitality in the mold and freeze-drying it. The biodegradable polymer has 0.003-27 weight% concentration. The hyaluronic acid solution has 0.001-3 weight% concentration.

Abstract translation: 提供了一种制造可生物降解的多孔混合载体和人造器官的方法，其获得了细胞粘附和增加的环境。 制造可生物降解的多孔混合载体的方法包括通过将含有10-50体积％的透明质酸溶液加入含有可生物降解聚合物的有机溶剂50-90体积％制备的混合物的方法，以提供生物相容性和模具中的活力 并冷冻干燥。 可生物降解的聚合物浓度为0.003-27％。 透明质酸溶液的浓度为0.001-3重量％。