신규 코지산 유도체 및 이의 제조방법
    4.
    发明授权
    신규 코지산 유도체 및 이의 제조방법 有权
    신규코지산유도체및이의제조방법

    公开(公告)号:KR100436014B1

    公开(公告)日:2004-06-12

    申请号:KR1020010076528

    申请日:2001-12-05

    Abstract: PURPOSE: Kojic acid derivatives and a preparation process thereof are provided, thereby inhibiting the melanin formation, so that the whiteness of the skin can be improved. CONSTITUTION: Kojic acid derivatives represented by formula(1) are provided, wherein R is C6H4-1,4-, C6H4-1,3-, CH=CHCH=CH, C5H3N-2,5- or C5H3N-3,5-. A process for preparing the Kojic acid derivatives of formula(1) comprises the steps of: (a) reacting thionyl chloride as chlorides with kojic acid in an organic solvent to prepare kojyl chloride; (b) reacting terephthalic acid, pyridine dicarboxylic acid and 2,4-hexadiene dioic acid with hydroxide salt in an organic solvent to prepare terephthalic acid salt, pyridine dicarboxylic acid salt and 2,4-hexadiene dioic acid salt; and (c) reacting terephthalic acid salt, pyridine dicarboxylic acid salt and 2,4-hexadiene dioic acid salt with kojyl chloride to prepare kojic acid dimer, wherein the chloride of the step (a) is thionyl chloride, oxalyl chloride, phosphorous trichloride and phosphorous oxychloride; the organic solvent of the step (a) is chloroform, methylene chloride, tetrahydrofuran, acetone, toluene and benzene; the hydroxide salt of the step (b) is sodium hydroxide and potassium hydroxide; and the organic solvent of the step (b) is ethanol, methanol, butanol and isopropyl alcohol.

    Abstract translation: 目的:提供曲酸衍生物及其制备方法,由此抑制黑色素形成,从而可以改善皮肤的白度。 构成:提供由式(1)表示的曲酸衍生物,其中R为C 6 H 4-1,4-,C 6 H 4 1-3,CH = CHCH = CH,C 5 H 3 N-2,5-或C 5 H 3 N-3,5- 。 制备式(1)曲酸衍生物的方法包括以下步骤:(a)使亚硫酰氯如氯化物与曲酸在有机溶剂中反应制备曲酸氯化物; (b)使对苯二甲酸,吡啶二羧酸和2,4-己二烯二酸与氢氧化物盐在有机溶剂中反应以制备对苯二甲酸盐,吡啶二羧酸盐和2,4-己二烯二酸盐; (c)将对苯二甲酸盐,吡啶二羧酸盐和2,4-己二烯二酸盐与高氯酸盐反应制备曲酸二聚体,其中步骤(a)的氯化物是亚硫酰氯,草酰氯,三氯化磷和 三氯氧磷; 步骤(a)的有机溶剂为氯仿,二氯甲烷,四氢呋喃,丙酮,甲苯和苯; 步骤(b)的氢氧化物盐是氢氧化钠和氢氧化钾; 并且步骤(b)的有机溶剂是乙醇,甲醇,丁醇和异丙醇。

    하눌타리의 천연 추출물을 함유하는 피부 탄력 증진용 또는 피부 보습 증진용 화장료 조성물
    5.
    发明授权
    하눌타리의 천연 추출물을 함유하는 피부 탄력 증진용 또는 피부 보습 증진용 화장료 조성물 失效
    하눌타리의천연추출물을함유하는피부탄력증진용또는피부보습증진용화장료조성물

    公开(公告)号:KR100433055B1

    公开(公告)日:2004-05-28

    申请号:KR1020010050180

    申请日:2001-08-21

    Abstract: PURPOSE: Provided is a cosmetic composition containing, as natural material, an extract of Trichosanthes kirilowii and Origanum majorana which are harmless to a human body such as toxicity, skin irritation, allergy, skin trouble or the like. The cosmetic composition enhances skin elasticity and skin moisturization. CONSTITUTION: The cosmetic composition contains 0.1% by weight of a natural extract of Trichosanthes kirilowii and/or Origanum majorana, based on the total dried weight of the composition. Trichosanthes kirilowii and/or Origanum majorana are mixed with 5 to 15 times of a solvent, extracted at 50 to 95deg.C for 3 to 20hr. The extract is filtered, aged, then distilled. The solvent is at least one selected from the group consisting of purified water, purified water of ultra pure water, hydrous butylene glycol, hydrous ethanol, hydrous propylene glycol and hydrous glycerine.

    Abstract translation: 目的:提供一种化妆品组合物,其含有作为天然材料的对人体无害,例如毒性,皮肤刺激,变态反应,皮肤问题等的瓜Tr Orig提取物和马鲁拉牛至提取物。 该化妆品组合物增强皮肤弹性和皮肤滋润。 构成:基于组合物的总干重,化妆品组合物含有0.1重量%的瓜Tr天竺葵(Trichosanthes kirilowi​​i)和/或马鲁拉牛至(Origanum majorana)的天然提取物。 瓜Tr and和/或马鲁拉牛至与5至15倍的溶剂混合,在50至95℃提取3至20小时。 将提取物过滤,陈化,然后蒸馏。 该溶剂是选自纯化水,超纯水纯化水,含水丁二醇,含水乙醇,含水丙二醇和含水甘油中的至少一种。

    안정화된 L-아스코빌산을 함유하는 수-유-수 다중에멀젼의 제조 방법 및 이를 함유하는 화장료 조성물
    6.
    发明公开
    안정화된 L-아스코빌산을 함유하는 수-유-수 다중에멀젼의 제조 방법 및 이를 함유하는 화장료 조성물 有权
    包含稳定的L-抗坏血酸的W / O / W型多型乳液的生产和包含其的化妆品组合物

    公开(公告)号:KR1020030097504A

    公开(公告)日:2003-12-31

    申请号:KR1020020034900

    申请日:2002-06-21

    Abstract: PURPOSE: A method of producing W/O/W-type multiple emulsions containing L-ascorbic acid stabilized in an aqueous phase using a gelling agent and an ion-masking agent is provided. The W/O/W-type multiple emulsions exhibit excellent stability in an aqueous state and thus can be effectively applied to cosmetics and pharmaceutical industry for improving skin wrinkles, whitening the skin and preventing skin aging. CONSTITUTION: In a method for stabilizing L-ascorbic acid in an aqueous phase, a gelling agent and an ion-masking agent are added to the aqueous phase, the pH is adjusted to neutrality with sodium hydroxide to give a W/O emulsion containing stabilized L-ascorbic acid. The W/O emulsion is reemulsified with a hydrophilic surfactant to give W/O/W-type multiple emulsions. The ion-masking agent is one or more selected from the group consisting of a monovalent salt containing NaCl and Na3PO4, a divalent salt containing CaCl2, CuCl2 and MgSO4, all of multivalent salt derivatives having a salt structure and a mixture thereof.

    Abstract translation: 目的:提供使用胶凝剂和离子掩蔽剂制备在水相中稳定的含有L-抗坏血酸的W / O / W型多重乳液的方法。 W / O / W型多重乳液在水性状态下表现出优异的稳定性,因此可以有效地应用于化妆品和制药工业,以改善皮肤皱纹,增白皮肤和防止皮肤老化。 构成:在水相中稳定L-抗坏血酸的方法中,向水相中加入胶凝剂和离子掩蔽剂,用氢氧化钠将pH调节至中性,得到含稳定化的W / O乳液 L-抗坏血酸。 将W / O乳液用亲水性表面活性剂再乳化,得到W / O / W型多重乳液。 离子掩蔽剂是选自含有NaCl和Na 3 PO 4的一价盐,含有CaCl 2,CuCl 2和MgSO 4的二价盐,所有具有盐结构的多价盐衍生物及其混合物中的一种或多种。

    하눌타리의 천연 추출물을 함유하는 피부 탄력 증진용 또는 피부 보습 증진용 화장료 조성물
    8.
    发明公开
    하눌타리의 천연 추출물을 함유하는 피부 탄력 증진용 또는 피부 보습 증진용 화장료 조성물 失效
    化妆品组合物含有天然提取物,用于改善皮肤健康和皮肤滋润的皮质醇和/或原味大豆

    公开(公告)号:KR1020030016547A

    公开(公告)日:2003-03-03

    申请号:KR1020010050180

    申请日:2001-08-21

    CPC classification number: A61K8/97 A61Q19/00 A61Q19/08 Y10S514/847

    Abstract: PURPOSE: Provided is a cosmetic composition containing, as natural material, an extract of Trichosanthes kirilowii and Origanum majorana which are harmless to a human body such as toxicity, skin irritation, allergy, skin trouble or the like. The cosmetic composition enhances skin elasticity and skin moisturization. CONSTITUTION: The cosmetic composition contains 0.1% by weight of a natural extract of Trichosanthes kirilowii and/or Origanum majorana, based on the total dried weight of the composition. Trichosanthes kirilowii and/or Origanum majorana are mixed with 5 to 15 times of a solvent, extracted at 50 to 95deg.C for 3 to 20hr. The extract is filtered, aged, then distilled. The solvent is at least one selected from the group consisting of purified water, purified water of ultra pure water, hydrous butylene glycol, hydrous ethanol, hydrous propylene glycol and hydrous glycerine.

    Abstract translation: 目的:提供一种化妆品组合物,其含有作为天然物质,对人体无害的毒素,皮肤刺激,过敏症,皮肤病等的天竺葵提取物和大and草。 化妆品组合物增强皮肤弹性和皮肤保湿作用。 构成:化妆品组合物含有0.1重量%的Trichosanthes kirilowi​​i和/或Origanum majorana的天然提取物,基于组合物的总干重。 将Trichosanthes kirilowi​​i和/或Origanum majorana与5至15倍的溶剂混合,在50至95℃下提取3至20小时。 将提取物过滤,老化,然后蒸馏。 溶剂是选自净化水,纯水纯水,含水丁二醇,含水乙醇,含水丙二醇和含水甘油的至少一种溶剂。

    안정화된 은 콜로이드 조성물, 안정화된 은 콜로이드조성물의 제조 방법 및 이를 함유하는 화장료 조성물
    9.
    发明公开
    안정화된 은 콜로이드 조성물, 안정화된 은 콜로이드조성물의 제조 방법 및 이를 함유하는 화장료 조성물 有权
    稳定的银胶体组合物,其制备方法和化妆品颜料组合物

    公开(公告)号:KR1020020085138A

    公开(公告)日:2002-11-16

    申请号:KR1020010024439

    申请日:2001-05-04

    CPC classification number: A61K8/19 A61K8/44 A61K8/65 A61K2800/413 A61Q19/00

    Abstract: PURPOSE: Provided is a stabilized silver colloidal composition with good stabilization against agglomeration, oxidation and discoloration, and high antibacterial property by treating Ag colloidal solution with nitrogen-contained polymer and metal chelate. CONSTITUTION: The stabilized silver colloidal composition comprises the components of: 0.0001-5wt.% of Ag colloidal solution; 0.01-10wt.% of at least one water soluble polymer containing nitrogen selected from chitin, gelatin, collagen, polyacryl amide, etc.; 0.001-50wt.% of at least one metal chelate selected from ethylene diamine tetraacetic acid(EDTA), citric acid, beta-alamine diacetic acid, etc.; and the rest of water. The stabilized Ag colloidal composition is prepared by dropping Ag colloidal solution obtained by dispersing Ag particles(

    Abstract translation: 目的:提供稳定的银胶体组合物,具有良好的凝聚稳定性,抗氧化和变色性能,通过用含氮聚合物和金属螯合物处理Ag胶体溶液具有高抗菌性能。 构成:稳定的银胶体组合物包含:0.0001-5重量%的Ag胶体溶液; 含有选自甲壳素,明胶,胶原,聚丙烯酰胺等的氮的至少一种水溶性聚合物的0.01-10重量% 0.001-50重量%的选自乙二胺四乙酸(EDTA),柠檬酸,β-阿拉伯二乙酸等的至少一种金属螯合物; 和其余的水。 通过将Ag颗粒(<= 5mm)分散到水中,加入含氮聚合物,然后加入金属螯合物以防止Ag胶体的聚集而获得的Ag胶体溶液制备稳定的Ag胶体组合物。 化妆品颜料组合物包含0.005-80重量%(基于化妆品颜料的总量)的Ag胶体,其能够长时间保存而没有化学防腐剂。

    결정성 무기광물을 함유한 피부 외용제 조성물
    10.
    发明公开
    결정성 무기광물을 함유한 피부 외용제 조성물 有权
    外用含水晶无机矿物的外用剂

    公开(公告)号:KR1020020054602A

    公开(公告)日:2002-07-08

    申请号:KR1020000083754

    申请日:2000-12-28

    CPC classification number: A61K8/19 A61Q19/00 A61Q19/08

    Abstract: PURPOSE: A skin preparation for external use containing crystalline inorganic mineral emitting strong wave energy at a wavelength area of 4 to 20 microns is provided which exhibits an excellent skin cell activating effect, skin moisturizing effect and skin aging-preventing effect. CONSTITUTION: The composition for external use for skin contains 0.01 to 25.0% by weight of crystalline inorganic mineral selected from tourmaline, crystal, precious stone, sapphire, ruby and turquoise, based on the total weight of the composition.

    Abstract translation: 目的:提供含有结晶无机矿物的外用皮肤制剂,其发射波长范围为4〜20微米的强波能,其具有优异的皮肤细胞活化作用,皮肤保湿效果和防止皮肤老化的作用。 构成:皮肤外用组合物含有0.01至25.0重量%的结晶无机矿物,其选自电气石,水晶,宝石,蓝宝石,红宝石和绿松石,基于组合物的总重量。

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