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1.发明授权나노유화기술에 의해 진세노사이드 Ｆ1을 함유하는 미세 유화 입자 및 이를 사용한 피부 외용제 조성물 有权나노유화기술에의해진세노사이드F1을함유하하는미세유화입자및이를사용한피부외용제조성물
公开(公告)号：KR100465976B1
公开(公告)日：2005-01-13
申请号：KR1020020000613
申请日：2002-01-05
Applicant: 주식회사 아모레퍼시픽그룹
Abstract: PURPOSE: An external agent composition for application to the skin is provided which is maximized in skin absorption by containing ginsenoside F1 as a major metabolite of Panax Ginseng prepared by a bioconversion process within nanoemulsions or liposomes using nanoemulsion techniques. Therefore, the external skin agent composition has improved transdermal absorption rate and an excellent skin aging-preventing effect such as wrinkle abatement. CONSTITUTION: An external skin agent composition contains 10¬-8 to 99.00% by weight of nanoemulsion particles having an average particle size of 30 to 500nm. The nanoemulsion particles contain 10¬-8 to 99.00% by weight of ginsenoside F1 of the formula 1 as an effective ingredient through nanoemulsion techniques, wherein the ginsenoside F1 is prepared by bioconversion of ginseng saponin and removal of sugar.
Abstract translation: 目的：提供一种用于皮肤的外用剂组合物，其通过含有人参皂甙F1作为通过纳米乳剂或脂质体内的生物转化方法使用纳米乳液技术制备的人参的主要代谢物而在皮肤吸收方面达到最大化。 因此，外用皮肤剂组合物具有改善的透皮吸收率和优异的皮肤老化防止效果，例如减少皱纹。 构成：外用皮肤剂组合物含有10重量％〜8重量％〜99.00重量％的平均粒度为30〜500nm的纳米乳液颗粒。 纳米乳剂颗粒通过纳米乳液技术含有10重量％〜8重量％〜99.00重量％的式1的人参皂苷F1作为有效成分，其中人参皂苷F1通过生物转化人参皂苷并除去糖来制备。
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公开(公告)号：KR100463167B1
公开(公告)日：2004-12-23
申请号：KR1020010019869
申请日：2001-04-13
Applicant: 주식회사 아모레퍼시픽그룹
CPC classification number: A61K9/5138
Abstract: A percutaneous releasing material and agent having characteristics that include a high stability of an active agent in the formulation, a high topical absorption rate, decreased irritation on the skin, and an increased tactile comfort. The percutaneous releasing material incorporates an external application agent composition that is prepared by using nanometer-sized polymer particles, i.e., particles having a size or diameter between approximately 1 nm and approximately 500 nm, and more preferably having a size between about 30 nm and about 150 nm. Further, the percutaneous releasing material and agent according to the present invention incorporate polymer particles that preferably contain a physiologically active agent that more readily penetrates through the stratum corneum to the upper layer of the dermis, whereby the physiologically active agent is effused into the skin while staying in the upper layer of dermis.
Abstract translation: 一种经皮释放材料和试剂，其具有包括制剂中活性剂的高稳定性，高局部吸收速率，对皮肤的刺激性降低以及增加的触觉舒适性。 经皮释放材料包含外部施用剂组合物，所述外部施用剂组合物通过使用纳米尺寸的聚合物颗粒（即，尺寸或直径在约1nm和约500nm之间，并且更优选地具有约30nm和约50nm之间的尺寸的颗粒 150纳米。 此外，根据本发明的经皮释放材料和试剂引入聚合物颗粒，其优选含有更容易穿过角质层到达真皮上层的生理活性剂，由此将生理活性剂渗入皮肤中 停留在真皮层的上层。
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3.发明授权3-아미노프로필토코페릴 포스페이트를 함유한나노유화입자 및 그의 제조방법, 및 이를 함유하는피부외용제 조성물 失效3-아미노프로필코코페릴포스페이트를함유한나노유화입자및그의제조방법，및이를함유하는피부외용제조성물
公开(公告)号：KR100456427B1
公开(公告)日：2004-11-10
申请号：KR1020010079358
申请日：2001-12-14
Applicant: 주식회사 아모레퍼시픽그룹
Abstract: PURPOSE: A process of preparing nanoemulsion particles including 3-aminopropyl tocopheryl phosphate(Toco-APPA) is provided. A skin agent for external use containing the nanoemulsion particle has no skin irritation and increases transdermal absorption of the Toco-APPA to produce tocopherol and 3-APPA(3-aminopropylphosphoric acid). The skin agent promotes antioxidant effect and collagen biosynthesis, by decomposition of transdermally absorbed Toco-APPA. CONSTITUTION: A nanoemulsion particle is characterized by comprising 0.001 to 50% by weight of 3-aminopropyl tocopheryl phosphate of formula(I), based on the total weight of the emulsion particle. In formula, R1, R2 and R3 are H or methyl and have at least one methyl group at the position of 5, 7 or 8 of tocopherol, A is -CH2-CH(CH3)- or -CH=C(CH3)-.
Abstract translation: 目的：提供制备包括3-氨丙基生育磷酸酯（Toco-APPA）的纳米乳剂颗粒的方法。 包含纳米乳剂颗粒的外用皮肤剂不具有皮肤刺激性并增加Toco-APPA的透皮吸收以产生生育酚和3-APPA（3-氨基丙基磷酸）。 皮肤剂通过经皮吸收的Toco-APPA的分解促进抗氧化作用和胶原蛋白生物合成。 组成：纳米乳液颗粒的特征在于包含基于乳液颗粒的总重量0.001至50重量％的式（I）的3-氨基丙基生育磷酸酯。 式中，R 1，R 2和R 3是H或甲基，并且在生育酚的5,7或8位具有至少一个甲基，A是-CH 2 -CH（CH 3） - 或-CH = C（CH 3） - 。
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4.发明授权경피흡수 촉진 능력이 우수한 식물성 나노입자의 제조 및이를 함유하는 화장료 및 의약용 외용제 조성물 有权경피흡수촉진능력이우수한식물성나노입자의제조및이를함유하는화장료및의약용외용제조성물
公开(公告)号：KR100422763B1
公开(公告)日：2004-03-12
申请号：KR1020020002701
申请日：2002-01-17
Applicant: 주식회사 아모레퍼시픽그룹
Abstract: PURPOSE: Provided is a process of preparing nanoparticles having excellent transdermal absorption-promoting effect while at the same time improving physicochemical stability of nanoparticles when applied to the skin by adding alcohol, diol or polydiol to a formulation. Therefore, the nanoparticles provide enhanced transdermal absorption property and are thus used as a cosmetic and pharmaceutical compositions having a desired effect on the skin. CONSTITUTION: Nanoparticles contain a physiologically active component thereinside and have a particle size of 10 to 300nm. They are manufactured using phospholipid or a derivative thereof derived from lecithin or derivatives thereof. During the manufacture of the nanoparticles, monoalcohols, diols or polyols is added as alcohol.
Abstract translation: 目的：提供一种制备具有优异透皮吸收促进作用的纳米颗粒的方法，同时通过向制剂中加入醇，二醇或聚二醇来改善纳米颗粒在施用于皮肤时的物理化学稳定性。 因此，纳米粒子提供增强的透皮吸收性质，因此用作对皮肤具有所需效果的化妆品和药物组合物。 构成：纳米粒子内部含有生理活性组分，粒径为10-300nm。 它们使用衍生自卵磷脂或其衍生物的磷脂或其衍生物制造。 在制造纳米颗粒期间，一元醇，二元醇或多元醇作为醇加入。
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公开(公告)号：KR1020030060018A
公开(公告)日：2003-07-12
申请号：KR1020020000614
申请日：2002-01-05
Applicant: 주식회사 아모레퍼시픽그룹
CPC classification number: A61K8/63 , A61K8/14 , A61K8/553 , A61K8/66 , A61Q19/00 , A61Q19/08 , B82Y5/00
Abstract: PURPOSE: An external agent composition for application to the skin is provided which contains a compound K prepared by bioconversion of ginseng saponin as an effective ingredient. By the inclusion of the compound K as a major metabolite of Panax Ginseng into nanoemulsions or liposomes using nanoemulsion techniques, the agent composition has improved transdermal absorption and excellent skin aging-preventing effect such as wrinkle abatement. CONSTITUTION: An external skin agent composition contains 10¬-8 to 99.00% by weight of nanoemulsion particles, the nanoemulsion particles contain 0.001 to 30% by weight of a compound K of the formula 1. The compound K is prepared by acid hydrolysis, base hydrolysis or enzyme hydrolysis of a Panax Ginseng extract. The nanoemulsion particles having an average particle size of 30 to 500nm include liposomes containing lecithin, a lecithin derivative and a co-emulsifier.
Abstract translation: 目的：提供一种适用于皮肤的外用剂组合物，其含有通过人参皂苷生物转化制备的化合物K作为有效成分。 通过使用纳米乳液技术将化合物K作为人参的主要代谢物纳入纳米乳剂或脂质体中，所述药剂组合物具有改善的经皮吸收和优异的皮肤老化防止效果，例如皱纹消除。 构成：外用皮肤剂组合物含有10〜8〜99.00重量％的纳米乳剂颗粒，纳米乳剂颗粒含有0.001〜30重量％的式1化合物K.化合物K是通过酸水解，碱 人参提取物的水解或酶水解。 平均粒径为30〜500nm的纳米乳剂粒子包含含有卵磷脂，卵磷脂衍生物和辅助乳化剂的脂质体。
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Patent Agency Ranking
公开(公告)号：KR1020030046543A
公开(公告)日：2003-06-18
申请号：KR1020010073810
申请日：2001-11-26
Applicant: 주식회사 아모레퍼시픽그룹
Abstract: PURPOSE: A skin composition for external use containing a nano mineral aqueous solution is provided. Therefore, the composition has skin moisturizing effect, cell activating effect and a transdermally absorption promoting effect of a physiologically active ingredient. CONSTITUTION: A skin composition is prepared by including retinol or co-enzyme Q10 as an active ingredient into clustered water of a nano mineral aqueous solution. The nano mineral aqueous solution contains 0.01 to 500mM mineral, in particular 0.1 to 100mM calcium as a main ingredient. The nano mineral aqueous solution contains: cations such as alkali cation metal species, alkaline earth cation species, cation transition metal species or Group III elements; and anions such as Group VII elements, oxides of Group VII elements, low molecular compounds or high molecular compounds of an organic anion.
Abstract translation: 目的：提供含有纳米矿物质水溶液的外用皮肤组合物。 因此，该组合物具有皮肤保湿作用，细胞活化作用和生理活性成分的经皮吸收促进作用。 构成：通过将视黄醇或辅酶Q10作为活性成分包含在纳米矿物质水溶液的聚集水中制备皮肤组合物。 纳米矿物质水溶液含有0.01至500mM矿物质，特别是0.1至100mM钙作为主要成分。 纳米矿物质水溶液含有阳离子如碱金属阳离子，碱土阳离子，阳离子过渡金属或III族元素; 和阴离子如VII族元素，VII族元素的氧化物，低分子化合物或有机阴离子的高分子化合物。
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公开(公告)号：KR1020030009571A
公开(公告)日：2003-02-05
申请号：KR1020010030988
申请日：2001-06-02
Applicant: 주식회사 아모레퍼시픽그룹
IPC: A61K31/685 , A61K31/665
Abstract: PURPOSE: A process of stabilizing lecithin at room temperature for a long period time by mixing lecithin with tocopherol derivatives is provided. Therefore, the stabilizing process does not need separate purifying and separating processes, the mixed composition of lecithin and tocopherol derivatives can be included in foods, cosmetics, drugs or the like. CONSTITUTION: A tocopherol derivative of formula(I) is added to lecithin in a ratio of 0.01 to 5.0 times, based on the total weight of lecithin. In formula, R1, R2 and R3 are H or methyl, at least one of R1, R2 and R3 is methyl, A is CH2-CH(CH3)- or CH=C(CH3)-. For an example, 9.87g phosphorous oxychloride is dissolved in 10ml THF and added with a mixture of 21.54g α-tocopherol, 6.10g triethylamine and 40mg THF to produce tocopherol dichlorophosphate. Then the tocopherol dichlorophosphate is added with a mixture 3.76g 3-amino-1-propanol, 11.11g triethanolamine and 20ml THF for 1hr to produce 2-tocopherol tetrahydro-2H-1,3,2-oxazaphosphorine P-oxide. The 2-tocopherol tetrahydro-2H-1,3,2-oxazaphosphorine P-oxide is added with hydrocholic acid and agitated after removing triethylammonium chloride to produce 25g 3-aminopropyl-α-tocopherol phosphate.
Abstract translation: 目的：提供通过将卵磷脂与生育酚衍生物混合，在室温下长时间稳定卵磷脂的方法。 因此，稳定化方法不需要单独的纯化和分离过程，卵磷脂和生育酚衍生物的混合组合物可以包括在食品，化妆品，药物等中。 构成：基于卵磷脂的总重量，将式（I）的生育酚衍生物以0.01至5.0倍的比例加入到卵磷脂中。 在式中，R 1，R 2和R 3为H或甲基，R 1，R 2和R 3中的至少一个为甲基，A为CH 2 -CH（CH 3） - 或CH = C（CH 3） - 。 例如，将9.87g磷酰氯溶于10ml THF中，并加入21.54gα-生育酚，6.10g三乙胺和40mg THF的混合物，生成二磷酸生育酚。 然后向三氯磷酸生育酚中加入3.76g 3-氨基-1-丙醇，11.11g三乙醇胺和20ml THF的混合物1小时，得到2-生育酚四氢-2H- 1,3,2-oxazaphosphorine P-氧化物。 加入2-生育酚四氢-2H-1,3,2-氧氮杂磷酸P-氧化物，加入氢氧化钠，除去三乙基氯化铵后搅拌，得到25g 3-氨基丙基-α-生育酚磷酸酯。
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8.发明公开
公开(公告)号：KR1020020092622A
公开(公告)日：2002-12-12
申请号：KR1020010031360
申请日：2001-06-05
Applicant: 주식회사 아모레퍼시픽그룹
CPC classification number: B82Y5/00 , A61K8/0208 , A61K8/046 , A61K8/06 , A61K8/553 , A61K8/678 , A61K9/0014 , A61K9/1075 , A61K47/24 , A61K2800/21 , A61K2800/413 , A61Q19/00
Abstract: PURPOSE: Provided are a stabilization method of a nano-emulsion particle using tocopheryl derivatives which keep physiologically active components stable for a long time, and an external application for skin containing the stabilized nano-emulsion. CONSTITUTION: In the manufacturing of a nano-emulsion particle using lecithin, the stabilization method of the nano-emulsion particle is characterized by adding tocopheryl derivatives of the formula(I) in the amount of 0.01-10 times by the total weight of lecithin. In the formula(I), R1, R2 and R3 are H or a methyl group and at least one of them is a methyl group; and A is CH2-CH(CH3)- or CH=C(CH3)-. The nano-emulsion particle contains a physiologically active material.
Abstract translation: 目的：提供使用生物基因衍生物的稳定化方法，其使生理活性成分长期保持稳定，外用于含有稳定化纳米乳剂的皮肤。 构成：在使用卵磷脂的纳米乳液颗粒的制造中，纳米乳液颗粒的稳定化方法的特征在于通过加入式（I）的生育酚衍生物，其量为卵磷脂总重量的0.01-10倍。 在式（I）中，R 1，R 2和R 3为H或甲基，并且其中至少一个为甲基; A是CH 2 -CH（CH 3） - 或CH = C（CH 3） - 。 纳米乳剂颗粒含有生理活性物质。
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公开(公告)号：KR1020010018695A
公开(公告)日：2001-03-15
申请号：KR1019990034754
申请日：1999-08-21
Applicant: 주식회사 아모레퍼시픽그룹
IPC: C07D309/32
Abstract: PURPOSE: Provided is a method for manufacturing a kojic acid derivative which shows a stability in water, and consequently, prevents decolorization and suits long term storage, when applied in manufacturing cosmetics. CONSTITUTION: Kojic acid is manufactured by the following steps of: i) reacting 3-amino-1-propanol and phosphorous oxychloride in an equivalence ratio of 1:1-1.3, in the presence of organic bases, under organic solvent at 0-5 deg.C for 1-2 hours to make 2-chlorotetrahydro-2H-1,3,2-oxaza phosphorin P-oxide; ii) reacting 2-chlorotetrahydro-2H-1,3,2-oxaza phosphorin P-oxide and kojic acid, in the presence of bases, under organic solvent; iii) filtering the solution, adding purified water to remnants, and hydrolyzing the mixture at 5-100 deg.C for 3-10 hours: and iv) crystallizing the mixture with polar organic solvent.
Abstract translation: 目的：提供在制造化妆品中时表现出稳定性的曲酸衍生物的制造方法，因此防止脱色，并适合长期保存。 构成：通过以下步骤制备曲酸：i）在有机溶剂存在下，在有机溶剂存在下，在0-5℃下，使3-氨基-1-丙醇和三氯氧化磷以1：1-1.3的当量比反应 加热1-2小时，得到2-氯四氢-2H-1,3,2-氧杂磷杂磷素P-氧化物; ii）在碱的存在下，在有机溶剂下，使2-氯四氢-2H-1,3,2-氧杂磷杂磷素P-氧化物和曲酸反应; iii）过滤溶液，向残留物中加入纯化水，并在5-100℃下将混合物水解3-10小时：和iv）用极性有机溶剂使混合物结晶。
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10.发明授权
公开(公告)号：KR100537952B1
公开(公告)日：2005-12-21
申请号：KR1020010019821
申请日：2001-04-13
Applicant: 주식회사 아모레퍼시픽그룹
IPC: A61K9/48
Abstract: 본 발명은 화장품에 사용되는 수용성 활성성분을 함유하는 마이크로캡슐에 있어서, 활성성분을 다량 함유하면서 그들의 안정성을 향상시키기 위하여 내부구조를 중공형으로 하고, 소수성 고분자로 제조한 중공형 소수성 고분자 마이크로캡슐 및 이의 제조방법, 및 이를 함유하는 화장료 조성물에 관한 것이다.
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