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    세포내 유전자 전달용 복합체, 이의 제조 방법 및 이를 이용한 세포내로의 유전자 전달 방법
    2.
    发明公开
    세포내 유전자 전달용 복합체, 이의 제조 방법 및 이를 이용한 세포내로의 유전자 전달 방법 有权
    用于将基因递送至细胞的组合物，其制备方法以及将基因递送至使用该细胞的细胞的方法

    公开(公告)号：KR1020110090661A

    公开(公告)日：2011-08-10

    申请号：KR1020100010582

    申请日：2010-02-04

    Applicant: 포항공과대학교 산학협력단 ,  전남대학교산학협력단

    Inventor： 김원종 ,  손세진

    IPC: A61K48/00 ,  A61P35/00

    CPC classification number: A61K48/00 ,  C12N15/1135

    Abstract: PURPOSE: An intracellular gene delivery composite containing a cationic polymer and cancer-targeting substances is provided to enable cancer therapy using various genes. CONSTITUTION: An intracellular gene delivery composite contains a cationic polymer and cancer-targeting substance. The cationic polymer has ester linkage, amide bond, disulfide bond, phosphate bond, or combination thereof. The cationic polymer is polyethylene imide(PEI), poly-L-lysine(PLL), chitosan, or dendrimer. The cancer-targeting substance is RGD peptide, NGR peptide, transferring, or folate. The gene is gDNA, cDNA, pDNA, mRNA, tRNA, rRNA, siRNA, miRNA, or antisense nucleotide. A method for preparing the composite comprises a step of conjugating the cancer-targeting substance to the cationic polymer using polyethylene glycol.

    Abstract translation: 目的：提供含有阳离子聚合物和癌症靶向物质的细胞内基因递送复合物，以使癌症能够使用各种基因进行治疗。 构成：细胞内基因递送复合物含有阳离子聚合物和癌症靶向物质。 阳离子聚合物具有酯键，酰胺键，二硫键，磷酸键或其组合。 阳离子聚合物是聚酰亚胺（PEI），聚-L-赖氨酸（PLL），壳聚糖或树枝状聚合物。 癌症靶向物质是RGD肽，NGR肽，转移或叶酸。 该基因是gDNA，cDNA，pDNA，mRNA，tRNA，rRNA，siRNA，miRNA或反义核苷酸。 制备复合物的方法包括使用聚乙二醇将癌症靶向物质与阳离子聚合物共轭的步骤。

    표적 세포에 대한 폴리뉴클레오티드 전달체
    5.
    发明公开
    표적 세포에 대한 폴리뉴클레오티드 전달체 有权
    多核苷酸递送复合物用于靶向细胞

    公开(公告)号：KR1020120067168A

    公开(公告)日：2012-06-25

    申请号：KR1020100128622

    申请日：2010-12-15

    Applicant: 포항공과대학교 산학협력단

    Inventor： 김원종 ,  황도원 ,  이동수 ,  손세진

    IPC: C12N15/11 ,  C12N15/87 ,  A61K47/42 ,  A61K48/00

    CPC classification number: C12N15/85 ,  A61K9/0019 ,  A61K47/34 ,  A61K47/59 ,  A61K47/62 ,  A61K47/6455 ,  C07K14/005 ,  C12N15/87 ,  C12N2760/20122 ,  C12N2810/6081

    Abstract: PURPOSE: A polynucleotide delivering complex containing RVG peptide-conjugated cationic polymers is provided to effectively and safely deliver polynucleotides to target cells. CONSTITUTION: A polynucleotide delivering complex contains RVG(rabies virus glycoprotein) peptide-conjugated cationic polymers. The polymers have ester bond, amide bond, disulfice bond, phosphate bond, or combination thereof. The cationic polymers are polyethylene imine(PEI), poly-L-lysine(PLL), chitosan, or dendrimer. The polynucleotide delivering complex has non-peptidyl polymers between the RVG peptide and cationic polymers. The non-peptidyl polymers are polyethylene glycol.

    Abstract translation: 目的：提供含有RVG肽缀合的阳离子聚合物的复合物的多核苷酸，以有效和安全地将多核苷酸递送至靶细胞。 构成：多核苷酸递送复合物含有RVG（狂犬病病毒糖蛋白）肽缀合的阳离子聚合物。 聚合物具有酯键，酰胺键，二硫键，磷酸键或其组合。 阳离子聚合物是聚乙烯亚胺（PEI），聚-L-赖氨酸（PLL），壳聚糖或树枝状聚合物。 递送复合物的多核苷酸在RVG肽和阳离子聚合物之间具有非肽基聚合物。 非肽基聚合物是聚乙二醇。

    멤브레인과 그 제조 방법
    6.
    发明公开
    멤브레인과 그 제조 방법 有权
    膜及其制造方法

    公开(公告)号：KR1020130018020A

    公开(公告)日：2013-02-20

    申请号：KR1020110080828

    申请日：2011-08-12

    Applicant: 포항공과대학교 산학협력단

    Inventor： 김진곤 ,  장상신 ,  양승윤 ,  전금혜 ,  김원종 ,  손세진 ,  김현우

    IPC: B82B1/00 ,  B82B3/00 ,  G01N33/52

    CPC classification number: G01N27/40 ,  B32B3/12 ,  B32B3/266 ,  B32B27/08 ,  B32B27/302 ,  B32B2333/12 ,  B82Y30/00 ,  B82Y40/00 ,  G01N27/44791 ,  G01N33/48721 ,  Y10T428/24149 ,  Y10T428/24273 ,  Y10T428/249978 ,  Y10T428/249979 ,  Y10T428/24998

    Abstract: PURPOSE: A manufacturing method of membrane is provided to form nanopores necessary for DNA analysis by introducing specific functional group on a wall of nanopores. CONSTITUTION: A membrane comprises a supporting member(100) and a polymer layer(200). The polymer layer is located above the supporting member, and comprises multiple nanopores(80). The multiple nanopores have inner walls, and the walls are comprised of polymer material of `end substituted with functional group` block structure. The functional group may be one of -COOH, -NH2, and -SH. The block structure of polymer material may be PMMA block(60). The membrane manufacturing method comprises the following steps. The alignment layer is formed into PS-ran-PMMA on the substrate including the sacrificing layer. The solution including PS-b-PMMA-diCOOH is applied on the alignment layer to form the polymer layer. The polymer layer is dipped in the acetic acid to form multiple nanopores on the polymer layer with `PMMA block as inner wall.

    Abstract translation: 目的：提供膜的制造方法，通过在纳米孔的壁上引入特定的官能团来形成DNA分析所需的纳米孔。 构成：膜包括支撑构件（100）和聚合物层（200）。 聚合物层位于支撑构件上方，并且包括多个纳米孔（80）。 多个纳米孔具有内壁，并且壁由末端被官能团阻挡结构取代的聚合物材料组成。 官能团可以是-COOH，-NH2和-SH之一。 聚合物材料的嵌段结构可以是PMMA嵌段（60）。 膜制造方法包括以下步骤。 取向层在包括牺牲层的基板上形成PS-ran-PMMA。 将包含PS-b-PMMA-diCOOH的溶液施加在取向层上以形成聚合物层。 将聚合物层浸入乙酸中以在PMMA嵌段作为内壁的聚合物层上形成多个纳米孔。

    생체고분자 및 중합된 핵산 복합체를 포함하는 핵산 전달체
    7.
    发明公开
    생체고분자 및 중합된 핵산 복합체를 포함하는 핵산 전달체 无效
    包含聚核酸和生物反应器的核酸递送复合物

    公开(公告)号：KR1020130136862A

    公开(公告)日：2013-12-13

    申请号：KR1020120060594

    申请日：2012-06-05

    Applicant: 포항공과대학교 산학협력단

    Inventor： 김원종 ,  손세진 ,  이두환

    IPC: A61K47/48 ,  A61K47/42 ,  A61K47/30 ,  A61K31/7105

    CPC classification number: A61K47/59 ,  A61K31/7105 ,  A61K31/711 ,  A61K47/42 ,  Y10S514/824 ,  Y10S514/825 ,  Y10S514/866 ,  Y10S514/885 ,  Y10S514/912 ,  Y10S514/925

    Abstract: The present invention relates to a complex for nucleic acid delivery comprising a biopolymer whereon a target peptide is combined and poly nucleic acid and, more desirably, the provision of the complex for nucleic acid delivery wherein the poly nucleic acid and a biopolymer which is produced by combination of a cationic polymer connected with biodegradable bond and the target peptide are combined. The complex for nucleic acid delivery according to the present invention comprises a biodegradable polymer, a target substance, and the poly nucleic acid, thereby selectively delivering nucleic acid to target cells like cancer cells and being degradable in the cells. Accordingly, the complex for delivering nucleic acid to the cell according to the present invention has useful effect in minimizing toxicity due to degradability in the cells as well as the amount of therapeutic nucleic acid induced into normal cells by the use of poly nucleic acid in case of being used for gene therapies against various diseases, thereby maximizing the utilization rate of the nucleic acid injected into the body.

    Abstract translation: 本发明涉及用于核酸递送的复合物，其包含其中组合目标肽的生物聚合物，并且更理想地，提供用于核酸转运的复合物，其中所述多核酸和生物聚合物由 将与生物可降解键连接的阳离子聚合物和靶肽的组合组合。 根据本发明的用于核酸递送的复合物包含可生物降解的聚合物，靶物质和多核酸，从而选择性地将核酸递送至诸如癌细胞的靶细胞并且可在细胞中降解。 因此，根据本发明的用于将核酸递送至细胞的复合物在由于细胞中的降解性引起的毒性以及通过使用多核酸在正常细胞中诱导的治疗性核酸的量的最小化方面具有有效的作用 用于针对各种疾病的基因治疗，从而最大化注射到体内的核酸的利用率。

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