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公开(公告)号：KR100378323B1
公开(公告)日：2003-03-29
申请号：KR1019990014356
申请日：1999-04-22
IPC: C07H13/08
CPC classification number: A61K31/704 , A61K36/69
Abstract: The present invention relates to psychotropic polygalasaponins and its extraction and isolation from the roots of Polygalae tenuifolia. The inhibitory activity of the extract from the roots of Polygalae tenuifolia on stereotyped behaviors and climbing behaviors induced by apomorphine was examined, and a single extract fraction that showed an activity particularly in behavioral pharmacology model was obtained from the roots of Polygalae tenuifolia. The object of the invention is therefore aimed at providing a new version of antipsychotic drug, polygalasaponic compound itself and a method to extract and isolate polygalasaponic compound from the roots of Polygalae Tenuifolia.
Abstract translation: 本发明涉及精神性多果皂苷及其从远志（Polygalae tenuifolia）根提取和分离。 研究了远志根部提取物对阿朴吗啡诱导的刻板行为和爬行行为的抑制活性，并从远志草的根部获得了一种特别在行为药理学模型中表现出活性的单一提取物部分。 因此，本发明的目的是提供一种新的抗精神病药物，多聚半乳糖化合物本身以及从远志藤根提取和分离多聚半乳糖化合物的方法。
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公开(公告)号：KR1020000066933A
公开(公告)日：2000-11-15
申请号：KR1019990014356
申请日：1999-04-22
IPC: C07H13/08
CPC classification number: A61K31/704 , A61K36/69
Abstract: PURPOSE: A psychotropic polygalasaponin based compound is provided which inhibits a stereotyped behavior and climbing behavior which are induced by apomorphine. CONSTITUTION: A psychotropic polygalasaponin is represented by formula 1 representation. An extraction method are characterized by comprising the following steps: (i)after grinding Polygalae Radix up to 70-230 mesh, extracting three times with 3-5 fold amount of alcohol solution; (ii)evaporating and condensing the filtrate at 70-76 cm Hg and at 60-70°C; (iii)after suspending the condensate in distilled water of 10 fold volume ratio, shaking the above thing by adding alcohol solvent of 1-2 fold and extracting three times and separating alcohol layer; (iv)condensing the above alcohol solvent fraction at 70-76 cmHg and at 60-70°C and obtaining an extract; (v)after suspending the above extract with distilled water of 50-100 fold adsorbing in resin HP-20 and draining active material with 70% methanol and condensing for obtaining an extract; (vi)after condensing the above extract with distilled water of 50-100 fold 2-3 times in common ratio, suspending homogeneously with same amount of distilled water and freeze-drying for obtaining a powder extract; (vii)dissolving the powder extract in ether and obtaining a precipitate;(viii)after saturating the precipitate with distilled water, passing through HP-20 resin and eluting an active site with methanol and adsorbing in silica gel and eluting active material by using ethyl acetate/methanol/water; (ix)adsorbing the active material in silica gel again and fractionating with mixed solvent of trichloro methane/methanol/ethanol/10%-acetic acid.
Abstract translation: 目的：提供一种精神分析多聚赖草皂苷的化合物，其抑制由阿朴吗啡诱导的定型行为和攀爬行为。 构成：精神分裂多糖分子由式1表示。 提取方法的特征在于包括以下步骤：（i）研磨多达70-230目后，用3-5倍量的醇溶液萃取三次; （ii）在70-76cm Hg和60-70℃下蒸发并冷凝滤液; （iii）将冷凝物悬浮在10倍体积比的蒸馏水中后，加入1-2倍的酒精溶剂振荡上述物质，萃取3次，分离醇层; （iv）将上述醇溶剂级分在70-76cmHg和60-70℃下冷凝并得到提取物; （v）将吸附在树脂HP-20中的50-100倍的蒸馏水悬浮在上述提取物上，并用70％甲醇排出活性物质并冷凝得到提取物; （vi）将上述提取物与常规比例为50-100倍的蒸馏水冷凝2-3次后，用相同量的蒸馏水均匀悬浮，冷冻干燥得到粉末提取物; （vii）将粉末提取物溶解在乙醚中并获得沉淀物;（viii）在用蒸馏水使沉淀物饱和后，通过HP-20树脂并用甲醇洗脱活性位点并吸附在硅胶中，并用乙基 乙酸乙酯/甲醇/水; （ix）再次将活性物质吸附在硅胶中，并用三氯甲烷/甲醇/乙醇/ 10％乙酸的混合溶剂进行分馏。
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公开(公告)号：KR100569245B1
公开(公告)日：2006-04-10
申请号：KR1020040105628
申请日：2004-12-14
Applicant: 한국과학기술연구원
Abstract: 본 발명은 불화 금속계 촉매를 이용한 펜타플루오로에틸 요오다이드(C
2 F
5 I)의 제조방법에 관한 것으로써, 더욱 상세하게는 요오드(I
2 ), 오불화요오드(IF
5 ) 및 테트라플루오로에틸렌(TFE)의 반응 시 반응촉매로 삼불화알루미늄(AlF
3 ), 불화크롬(CrF
3 ) 및 불화마그네슘(MgF
2 )중에서 선택된 특정의 불화 금속계 촉매를 사용하거나, 또는 상기 불화 금속계 촉매에 추가로 안티몬계 촉매가 일정비로 혼합된 복합금속계 촉매를 사용하여 반연속식 공정으로 부생성물인 육불화에탄(C
2 F
6 )의 생성을 억제하면서 고수율로 펜타플루오로에틸 요오다이드(C
2 F
5 I)의 수득이 가능한 불화 금속계 또는 복합금속계 촉매를 이용한 펜타플루오로에틸 요오다이드(C
2 F
5 I)의 제조방법에 관한 것이다.
펜타플루오로에틸 요오다이드, 테트라플로오로에틸렌, 오불화요오드, 요오드, 불화 금속계 촉매, 복합금속계 촉매, 반연속식 공정Abstract translation: 生产五氟乙基碘的方法本发明涉及一种生产五氟乙基碘（C）的方法
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