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公开(公告)号：KR101481952B1
公开(公告)日：2015-01-22
申请号：KR1020120038239
申请日：2012-04-13
Applicant: 한국과학기술연구원
IPC: C07D211/42 , C07D241/28 , A61K31/44 , A61P25/00
Abstract: 본 발명은 뇌에서 mPTP의 작용을 선택적으로 억제하여 미토콘드리아의 기능을 향상시키는 신경보호제로서 작용하여 중추신경계 질환의 치료 또는 예방제로 효과를 보이는 유레아 유도체 또는 이의 약제학적으로 허용 가능한 염, 이들 화합물의 제조방법, 그리고 이들 화합물이 유효성분으로 함유된 약학조성물에 관한 것이다.
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公开(公告)号：KR1020130115696A
公开(公告)日：2013-10-22
申请号：KR1020120038239
申请日：2012-04-13
Applicant: 한국과학기술연구원
IPC: C07D211/42 , C07D241/28 , A61K31/44 , A61P25/00
Abstract: PURPOSE: A urea derivative is provided to selectively suppress the action of mPTP in the brain, thereby being used as a neuroprotective agent which improves the action of the mitochondria. CONSTITUTION: A urea derivative is denoted by chemical formula 1. A method for preparing the urea derivative comprises the steps of making a compound of chemical formula 2 react with isocyanate compounds or isothiocyanate compounds. The compound of chemical formula 2 is prepared by making a compound of chemical formula 3 react with benzyl halide compounds. A pharmaceutical composition for suppressing the action of mPTP contains the urea derivative or a pharmaceutically acceptable salt thereof as an active ingredient. A pharmaceutical composition for treating nervous diseases contains the urea derivative or a pharmaceutically acceptable salt thereof as an active ingredient.
Abstract translation: 目的：提供尿素衍生物以选择性抑制脑中mPTP的作用，从而用作改善线粒体作用的神经保护剂。 构成：以化学式1表示脲衍生物。制备尿素衍生物的方法包括使化学式2的化合物与异氰酸酯化合物或异硫氰酸酯化合物反应的步骤。 通过使化学式3的化合物与苄基卤化合物反应来制备化学式2的化合物。 用于抑制mPTP作用的药物组合物含有尿素衍生物或其药学上可接受的盐作为活性成分。 用于治疗神经疾病的药物组合物含有尿素衍生物或其药学上可接受的盐作为活性成分。
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