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公开(公告)号：KR101481952B1
公开(公告)日：2015-01-22
申请号：KR1020120038239
申请日：2012-04-13
Applicant: 한국과학기술연구원
IPC: C07D211/42 , C07D241/28 , A61K31/44 , A61P25/00
Abstract: 본 발명은 뇌에서 mPTP의 작용을 선택적으로 억제하여 미토콘드리아의 기능을 향상시키는 신경보호제로서 작용하여 중추신경계 질환의 치료 또는 예방제로 효과를 보이는 유레아 유도체 또는 이의 약제학적으로 허용 가능한 염, 이들 화합물의 제조방법, 그리고 이들 화합물이 유효성분으로 함유된 약학조성물에 관한 것이다.
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Patent Agency Ranking
公开(公告)号：KR1020130096900A
公开(公告)日：2013-09-02
申请号：KR1020120018466
申请日：2012-02-23
Applicant: 한국과학기술연구원
IPC: C07D403/04 , C07D249/06 , A61K31/41 , A61K31/4025
Abstract: PURPOSE: A triazole derivative is provided to be used as a restorative of mitochondrial dysfunction with effects of treating Alzheimer's diseases, Parkinson's disease, Huntington's disease, ischemic diseases, diabetes, and schizophrenia. CONSTITUTION: A compound is selected among a triazole derivative of chemical formula 1and a pharmaceutically acceptable salt thereof. A pharmaceutical composition for treating Alzheimer's disease, Parkinson's disease, Huntington's disease, ischemic disease, diabetes, and schizophrenia contains the compound as an active ingredient. A method for preparing the triazole compound comprises the step of reacting an azide compound of chemical formula 2 and an ethynyl benzene compound of chemical formula 3 by dipolar cycloaddition.
Abstract translation: 目的：提供三唑衍生物作为线粒体功能障碍的修复剂，具有治疗阿尔茨海默氏病，帕金森病，亨廷顿病，缺血性疾病，糖尿病和精神分裂症的作用。 构成：化合物选自化学式1的三唑衍生物及其药学上可接受的盐。 用于治疗阿尔茨海默病，帕金森病，亨廷顿病，缺血性疾病，糖尿病和精神分裂症的药物组合物含有该化合物作为活性成分。 制备三唑化合物的方法包括通过偶极环加成使化学式2的叠氮化合物与化学式3的乙炔基苯化合物反应的步骤。
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公开(公告)号：KR101435496B1
公开(公告)日：2014-08-28
申请号：KR1020120117057
申请日：2012-10-22
Applicant: 한국과학기술연구원
IPC: C07D235/08 , C07D235/14 , A61K31/4184 , A61P25/00
CPC classification number: C07D413/06 , C07D235/08 , C07D235/10 , C07D235/12 , C07D235/14 , C07D235/28 , C07D401/06 , C07D403/06 , C07D403/12
Abstract: 본 발명은 미토콘드리아의 기능을 조절하여 신경보호제로서의 약학적 활성을 보이는 벤즈이미다졸 유도체, 및 이 화합물이 유효성분으로 함유된 약제조성물에 관한 것이다.
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公开(公告)号：KR1020130115696A
公开(公告)日：2013-10-22
申请号：KR1020120038239
申请日：2012-04-13
Applicant: 한국과학기술연구원
IPC: C07D211/42 , C07D241/28 , A61K31/44 , A61P25/00
Abstract: PURPOSE: A urea derivative is provided to selectively suppress the action of mPTP in the brain, thereby being used as a neuroprotective agent which improves the action of the mitochondria. CONSTITUTION: A urea derivative is denoted by chemical formula 1. A method for preparing the urea derivative comprises the steps of making a compound of chemical formula 2 react with isocyanate compounds or isothiocyanate compounds. The compound of chemical formula 2 is prepared by making a compound of chemical formula 3 react with benzyl halide compounds. A pharmaceutical composition for suppressing the action of mPTP contains the urea derivative or a pharmaceutically acceptable salt thereof as an active ingredient. A pharmaceutical composition for treating nervous diseases contains the urea derivative or a pharmaceutically acceptable salt thereof as an active ingredient.
Abstract translation: 目的：提供尿素衍生物以选择性抑制脑中mPTP的作用，从而用作改善线粒体作用的神经保护剂。 构成：以化学式1表示脲衍生物。制备尿素衍生物的方法包括使化学式2的化合物与异氰酸酯化合物或异硫氰酸酯化合物反应的步骤。 通过使化学式3的化合物与苄基卤化合物反应来制备化学式2的化合物。 用于抑制mPTP作用的药物组合物含有尿素衍生物或其药学上可接受的盐作为活性成分。 用于治疗神经疾病的药物组合物含有尿素衍生物或其药学上可接受的盐作为活性成分。
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公开(公告)号：KR101428496B1
公开(公告)日：2014-08-13
申请号：KR1020120018466
申请日：2012-02-23
Applicant: 한국과학기술연구원
IPC: C07D403/04 , C07D249/06 , A61K31/41 , A61K31/4025
Abstract: 본 발명은 미토콘드리아의 기능을 조절하여 신경보호제로서의 약학적 활성을 보이는 트리아졸 유도체 및 이의 약제학적으로 허용 가능한 염, 이들 화합물의 제조방법, 그리고 이들 화합물이 유효성분으로 함유된 약제조성물에 관한 것이다.
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公开(公告)号：KR1020140050802A
公开(公告)日：2014-04-30
申请号：KR1020120117057
申请日：2012-10-22
Applicant: 한국과학기술연구원
IPC: C07D235/08 , C07D235/14 , A61K31/4184 , A61P25/00
CPC classification number: C07D413/06 , C07D235/08 , C07D235/10 , C07D235/12 , C07D235/14 , C07D235/28 , C07D401/06 , C07D403/06 , C07D403/12
Abstract: The present invention relates to a benzimidazole derivative which has pharmaceutical activity as a neuroprotective agent by modulating mitochondrial functions and a pharmaceutical composition comprising the same as an active ingredient. The benzimidazole derivative or a pharmaceutically acceptable salt thereof, according to the present invention, has an excellent activity as a neuroprotective agent affecting mitochondria, thereby can be used as a medicine for diseases such as Alzheimer′s disease, Parkinson′s disease, Huntington′s disease, ischemic brain disease, diabetes, and schizophrenia.
Abstract translation: 本发明涉及通过调节线粒体功能而具有作为神经保护剂的药学活性的苯并咪唑衍生物和包含其作为活性成分的药物组合物。 根据本发明的苯并咪唑衍生物或其药学上可接受的盐作为影响线粒体的神经保护剂具有优异的活性，因此可以用作诸如阿尔茨海默氏病，帕金森病，亨廷顿病， 缺血性脑病，糖尿病和精神分裂症。
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