-
公开(公告)号：KR1020040009018A
公开(公告)日：2004-01-31
申请号：KR1020020042794
申请日：2002-07-20
Applicant: 한국과학기술연구원
IPC: A61K31/245
CPC classification number: A61K9/5078 , A61K9/0095 , A61K9/5026 , A61K9/5031 , A61K31/14 , A61K31/245 , A61K45/06 , A61K2300/00
Abstract: PURPOSE: Provided is a p-glycoprotein inhibitor which comprises otilonium bromide as an effective ingredient, thereby increasing the absorption of otilonium bromide into the cell and bioavailability of the drug in the living body. CONSTITUTION: A p-glycoprotein inhibitor is characterized by comprising, as an effective ingredient, otilonium bromide that inhibits the activity of p-glycoprotein and increases the absorption of drugs into the cell. The composition is formulated into a sustained release preparation and releases drugs continuously for 12 hours.
Abstract translation: 目的：提供一种P-糖蛋白抑制剂，其包含溴化溴铵作为有效成分，从而增加溴化铵对细胞的吸收和生物体内药物的生物利用度。 构成：P-糖蛋白抑制剂的特征在于包含抑制β-糖蛋白活性的otilonium溴化物作为有效成分，并增加药物对细胞的吸收。 将组合物配制成持续释放制剂并连续释放药物12小时。
-
公开(公告)号：KR100503889B1
公开(公告)日：2005-07-26
申请号：KR1020020042794
申请日：2002-07-20
Applicant: 한국과학기술연구원
IPC: A61K31/245
CPC classification number: A61K9/5078 , A61K9/0095 , A61K9/5026 , A61K9/5031 , A61K31/14 , A61K31/245 , A61K45/06 , A61K2300/00
Abstract: 본 발명은 옥틸로늄 브로마이드의 약물의 세포내 흡수증가를 위한 p-당단백질 저해제로서의 신규한 용도에 관한 것이다. 보다 상세하게, 본 발명은 p-당단백질을 저해함으로써 항암제와 같은 약물과 동시에 또는 약물 투여 전에 경구로 투여 시에 약물의 세포내 흡수율 및 생체내 이용률을 향상시키는 p-당단백질 저해제로서의 옥틸로늄 브로마이드를 제공한다.
-
Search Results
2
records
(took 0.017 seconds)
