-
公开(公告)号：KR1020120107770A
公开(公告)日：2012-10-04
申请号：KR1020110025491
申请日：2011-03-22
Applicant: 한국과학기술연구원
Abstract: PURPOSE: A method for manufacturing an angiographic contrast medium containing lipiodol is provided to obtain the medium with excellent biocompatibility, homogeneity, and redispersibility. CONSTITUTION: A method for manufacturing a lipiodol-capsulated CT contast medium comprises: a step of mixing polyoxyethyelene sorbitan monooleate(Tween 80) of chemical formula 1 with lipiodol and dissolving; a step of adding a triblock copolymer solution of chemical formula 2(HO(C_2H_4O)_a(C_3H_6O)_b(C_2H_4O)_cH) to the mixture and stirring at 60-160 Deg. C.; and a step of cooling the mixture. The triblock copolymer is polaxamer. A contrast medium for computer tomography contains the nanocapsule containing the lipiodol.
Abstract translation: 目的：提供一种制备含有碘油的血管造影剂的方法，以获得具有优异生物相容性，均匀性和再分散性的培养基。 构成：制备碘油包封的CT对照培养基的方法包括：将化学式1的聚氧乙烯脱水山梨醇单油酸酯（吐温80）与碘油混合并溶解的步骤; 将化学式2的三嵌段共聚物溶液（HO（C 2 H 4 O）_a（C 3 H 4 O）_ c H）加入到混合物中并在60-160℃下搅拌的步骤。 C。; 和冷却混合物的步骤。 三嵌段共聚物是聚对苯二甲酸酯。 用于计算机断层扫描的造影剂包含含有碘油的纳米胶囊。
-
公开(公告)号：KR1020040009018A
公开(公告)日：2004-01-31
申请号：KR1020020042794
申请日：2002-07-20
Applicant: 한국과학기술연구원
IPC: A61K31/245
CPC classification number: A61K9/5078 , A61K9/0095 , A61K9/5026 , A61K9/5031 , A61K31/14 , A61K31/245 , A61K45/06 , A61K2300/00
Abstract: PURPOSE: Provided is a p-glycoprotein inhibitor which comprises otilonium bromide as an effective ingredient, thereby increasing the absorption of otilonium bromide into the cell and bioavailability of the drug in the living body. CONSTITUTION: A p-glycoprotein inhibitor is characterized by comprising, as an effective ingredient, otilonium bromide that inhibits the activity of p-glycoprotein and increases the absorption of drugs into the cell. The composition is formulated into a sustained release preparation and releases drugs continuously for 12 hours.
Abstract translation: 目的：提供一种P-糖蛋白抑制剂，其包含溴化溴铵作为有效成分，从而增加溴化铵对细胞的吸收和生物体内药物的生物利用度。 构成：P-糖蛋白抑制剂的特征在于包含抑制β-糖蛋白活性的otilonium溴化物作为有效成分，并增加药物对细胞的吸收。 将组合物配制成持续释放制剂并连续释放药物12小时。
-
Patent Agency Ranking
公开(公告)号：KR101308746B1
公开(公告)日：2013-09-12
申请号：KR1020100130142
申请日：2010-12-17
Applicant: 한국과학기술연구원
Abstract: 본 발명은 글리콜 키토산과 헤파린으로 표면이 개질된 약물전달용 생체적합성 고분자 전달체 및 그의 용도에 관한 것이다.
글리콜 키토산과 헤파린으로 표면이 개질된 본 발명의 약물전달용 생체적합성 고분자 전달체는, 제조 과정 중에 유기 용매가 사용되지 않으므로 생체 적합성이 우수하며, 글리콜 키토산과 헤파린으로 표면이 개질되어 혈류 내 체류성 및 순환성이 증가된다. 따라서, 상기 약물전달용 생체적합성 고분자 전달체는 생체 내 암조직 등의 표적 부위로 약물을 효율적으로 전달할 수 있으므로, 각종 질병의 치료를 위하여 광범위하게 사용할 수 있다.-
公开(公告)号：KR100750727B1
公开(公告)日：2007-08-22
申请号：KR1020060036394
申请日：2006-04-21
Applicant: 한국과학기술연구원
IPC: A61K31/722 , A61K38/04
Abstract: A composition containing chitosan and N-acetyl-L-cysteine is provided to promote cholesterol-reducing effects of chitosan and reactive oxygen-removing effects of N-acetyl-L-cysteine by increasing enteric disintegration and bioavailability of chitosan and N-acetyl-L-cysteine. The composition contains 5-97 wt.% of chitosan having 50-90% deacetylation and molecular weight of 1,000-5,000,000 dalton and 3-95 wt.% of N-acetyl-L-cysteine having 82-88% deacetylation and molecular weight of 2,500-530,000 dalton, wherein the N-acetyl-L-cysteine is contained together with acetate or ascorbic acid. The food contains the composition containing chitosan and N-acetyl-L-cysteine.
Abstract translation: 提供含有壳聚糖和N-乙酰-L-半胱氨酸的组合物以通过增加壳聚糖和N-乙酰-L的肠溶性和生物利用度来促进壳聚糖的胆固醇降低作用和N-乙酰-L-半胱氨酸的活性氧去除作用 半胱氨酸。 该组合物含有5-97重量％脱乙酰度为50-90％，分子量为1,000-5,000,000道尔顿的壳聚糖和3-95重量％N-乙酰-L-半胱氨酸，其脱乙酰度为82-88％，分子量为 2,500-53万道尔顿，其中N-乙酰-L-半胱氨酸与乙酸盐或抗坏血酸一起被包含。 食物含有含有壳聚糖和N-乙酰-L-半胱氨酸的组合物。
-
公开(公告)号：KR1020120089892A
公开(公告)日：2012-08-16
申请号：KR1020100130142
申请日：2010-12-17
Applicant: 한국과학기술연구원
CPC classification number: A61K47/30 , A61K9/1676 , A61K49/126
Abstract: PURPOSE: A biocompatible polymer delivery system for drug delivery with the surface modified by glycol chitosan and heparin is provided to enhance blood retention and circulation and to effectively deliver a drug to a target site of cancer tissue. CONSTITUTION: A method for preparing biocompatible polymer nano delivery system comprises: a step of mixing and dissolving polyoxyethylene sorbitan monooleate(Tween80) of chemical formula 1 with drug; a step of adding lecithin lipid of chemical formula 2 to the mixture and mixing; a step of impregnating the secondary mixture to a triblock copolymer solution of chemical formula 3(HO(C_2H_4O)_a(C_3H_6O)_b(C_2H_4O)_cH) to prepare a nano delivery system; and a step of adding glycol chitosan of chemical formula 4 and heparin solution of chemical formula 5 to the nano delivery system to modifier the surface of the nano delivery system.
Abstract translation: 目的：提供用于药物递送的生物相容性聚合物递送系统，其由乙二醇壳聚糖和肝素修饰，以增强血液保持和循环，并有效地将药物递送至癌组织的靶位点。 构成：制备生物相容性聚合物纳米递送系统的方法包括：将化学式1的聚氧乙烯山梨糖醇酐单油酸酯（吐温80）与药物混合并溶解的步骤; 将化学式2的卵磷脂脂加入混合物中并混匀; 将二次混合物浸渍到化学式3（HO（C 2 H 4 O）_a（C 3 H 6 O）_b（C 2 H 4 O）_cH）的三嵌段共聚物溶液中以制备纳米递送系统; 将化学式4的乙二醇壳聚糖和化学式5的肝素溶液加入到纳米递送系统中以改性纳米递送系统的表面的步骤。
-
公开(公告)号：KR100503889B1
公开(公告)日：2005-07-26
申请号：KR1020020042794
申请日：2002-07-20
Applicant: 한국과학기술연구원
IPC: A61K31/245
CPC classification number: A61K9/5078 , A61K9/0095 , A61K9/5026 , A61K9/5031 , A61K31/14 , A61K31/245 , A61K45/06 , A61K2300/00
Abstract: 본 발명은 옥틸로늄 브로마이드의 약물의 세포내 흡수증가를 위한 p-당단백질 저해제로서의 신규한 용도에 관한 것이다. 보다 상세하게, 본 발명은 p-당단백질을 저해함으로써 항암제와 같은 약물과 동시에 또는 약물 투여 전에 경구로 투여 시에 약물의 세포내 흡수율 및 생체내 이용률을 향상시키는 p-당단백질 저해제로서의 옥틸로늄 브로마이드를 제공한다.
-
公开(公告)号：KR101263733B1
公开(公告)日：2013-05-14
申请号：KR1020110025491
申请日：2011-03-22
Applicant: 한국과학기술연구원
Abstract: 본발명은리피오돌을함유하는컴퓨터단층촬영용혈관조영제의제조방법에관한것이다. 본발명에따른조영제는, 제조과정중에유기용매가사용되지않으므로생체적합성이우수하고, 양친매성성질을갖는고분자로감싸져있어서혈류내 체류성및 순환성이높으며, 균질성과재분산성이우수하다. 따라서, 기존의조영제가갖는짧은체내분포에기인하는문제를개선할수 있으므로, 각종질병의진단을위하여광범위하게사용할수 있다.
-
-
-
-
-
-
Search Results
7
records
(took 0.019 seconds)
