公开(公告)号：KR1020020090770A

公开(公告)日：2002-12-05

申请号：KR1020010029784

申请日：2001-05-29

Applicant: 한국과학기술연구원

Inventor： 손연수 ,  송릿다 ,  김관묵 ,  김영상

IPC: C07D487/22

Abstract: PURPOSE: Provided are tumor targeting water soluble porphyrin derivatives which form a complex with other anticancer agents and are thus used for delivering the anticancer agents to tumor tissues, and their preparation method and use, thereby minimizing an ill effect of an anticancer agent and increasing water-solubility. CONSTITUTION: The porphyrin derivative is represented by the formula(2), wherein m is zinc or two of hydrogen ions; Y is 0 or RX; R is selected from alkyl amine or alkylcarboxylate; and X is a halide ion.

Abstract translation: 目的：提供与其它抗癌剂形成复合物的肿瘤靶向水溶性卟啉衍生物，因此用于将抗癌剂递送至肿瘤组织及其制备方法和用途，从而最小化抗癌剂的不良作用和增加水 -solubility。 构成：卟啉衍生物由式（2）表示，其中m为锌或两个氢离子; Y为0或RX; R选自烷基胺或烷基羧酸盐; X为卤离子。