中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

5 records (took 0.019 seconds)

    다중영상화를 위한 금속 나노입자 및 그 용도
    2.
    发明公开
    다중영상화를 위한 금속 나노입자 및 그 용도 无效
    金属纳米颗粒多模式成像及其应用

    公开(公告)号：KR1020120089913A

    公开(公告)日：2012-08-16

    申请号：KR1020100131839

    申请日：2010-12-21

    Applicant: 한국과학기술연구원

    Inventor： 선인철 ,  김광명 ,  권익찬 ,  최귀원 ,  윤인찬 ,  안철희 ,  은대경

    IPC: A61K49/14 ,  A61K49/08 ,  A61K47/42 ,  A61K47/02

    CPC classification number: C12Q1/37 ,  B82Y5/00 ,  G01N33/54346 ,  G01N33/582 ,  G01N33/68 ,  G01N33/84

    Abstract: PURPOSE: A nanosensor containing glycol chitosan-coated gold nanoparticles, peptides, and fluorescent substances is provided to diagnose certain disease such as cancer. CONSTITUTION: A nanosensor for detecting protease contains glycol chitosan-coated gold nanoparticles, peptides, and fluorescent substances. The peptide has 9-15 amino acid containing a protease cleavage site. One end and the other end of the peptide are conjugated with fluorescent substances and glycol chitosan of gold nanoparticles, respectively. The protease includes matrix metalloproteinases(MMP), caspase , thrombine, or proteosome. The peptide has 9-15 amino acids including Pro-Leu-Gly-Val-Arg (SEQ ID NO: 1), Gly-Asp-Glu-Val-Asp-Ala-Pro(SEQ ID NO: 2), Phe-Pip-Arg-Ser(Pip=pipecolic acid)(SEQ ID NO: 3), Gly-Gly-Arg-Arg-Gly-Gly(SEQ ID NO: 4), Arg, or Lys.

    Abstract translation: 目的：提供含有乙二醇壳聚糖包被的金纳米颗粒，肽和荧光物质的纳米传感器来诊断某些疾病如癌症。 构成：用于检测蛋白酶的纳米传感器含有乙二醇壳聚糖包被的金纳米颗粒，肽和荧光物质。 该肽具有含有蛋白酶切割位点的9-15个氨基酸。 肽的一端和另一端分别与金纳米颗粒的荧光物质和乙二醇壳聚糖共轭。 蛋白酶包括基质金属蛋白酶（MMP），半胱天冬酶，血栓素或蛋白体。 肽具有9-15个氨基酸，包括Pro-Leu-Gly-Val-Arg（SEQ ID NO：1），Gly-Asp-Glu-Val-Asp-Ala-Pro（SEQ ID NO：2），Phe-Pip -Arg-Ser（Pip =哌可酸）（SEQ ID NO：3），Gly-Gly-Arg-Arg-Gly-Gly（SEQ ID NO：4），Arg或Lys。

    단백질 분해효소 검출 및 생체 내 영상화를 위한 금속 나노입자 및 그것의 용도
    4.
    发明授权
    단백질 분해효소 검출 및 생체 내 영상화를 위한 금속 나노입자 및 그것의 용도 失效
    一种基于金属纳米材料的蛋白成像探针及其应用

    公开(公告)号：KR100857770B1

    公开(公告)日：2008-09-09

    申请号：KR1020070035722

    申请日：2007-04-11

    Applicant: 한국과학기술연구원

    Inventor： 권익찬 ,  최귀원 ,  김광명 ,  안철희 ,  윤인찬 ,  이슬기 ,  박경순

    IPC: C01G23/04 ,  C04B35/465 ,  B82B3/00

    CPC classification number: A61K49/0056 ,  A61K49/0032 ,  A61K49/0065 ,  A61K49/0093 ,  C12Q1/37

    Abstract: A gold nanoparticle of peptide and cyanine phosphor is provided to selectively in vivo detect and image protease, and quantitatively analyze the expression amount of protease, so that the gold nanoparticle is useful as a sensor for realtime cell imaging and early diagnosis of non-hygroscopic disease by being selectively absorbed into the cell or tissue. A gold nanoparticle for imaging MMP(matrix metalloprotease) expressed in the cell or tissue contains a peptide with -SH end group which is specifically degraded by MMP coupled with a cyanine phosphor, wherein the peptide with -SH end group is Gly-Pro-Leu-Gly-Leu-Phe-Ala-Arg-Cys; and the MMP is MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13, MMP-14, MMP-15, MMP-16, MMP-17, MMP-18, MMP-19, MMP-20, MMP-21, MMP-22, MMP-23, MMP-24, MMP-25, MMP-26, MMP-27 or MMP-28.

    Abstract translation: 提供肽和花青荧光体的金纳米颗粒以选择性体内检测和图像蛋白酶，并定量分析蛋白酶的表达量，使得金纳米颗粒可用作实时细胞成像和非吸湿性疾病早期诊断的传感器 通过选择性地吸收到细胞或组织中。 用于成像在细胞或组织中表达的MMP（基质金属蛋白酶）的金纳米颗粒含有具有-SH端基的肽，其通过与花青磷光体偶联的MMP特异性降解，其中具有-SH端基的肽是Gly-Pro-Leu -Gly-LEU-PHE-ALA-精氨酸 - 半胱氨酸; MMP-1，MMP-2，MMP-3，MMP-7，MMP-8，MMP-9，MMP-10，MMP-11，MMP-12，MMP-13， 15，MMP-16，MMP-17，MMP-18，MMP-19，MMP-20，MMP-21，MMP-22，MMP-23，MMP-24，MMP-25，MMP-26， MMP-28。

Patent Agency Ranking