公开(公告)号：KR100466371B1

公开(公告)日：2005-01-13

申请号：KR1020030026907

申请日：2003-04-29

Applicant: 한국과학기술연구원

Inventor： 김유승 ,  강순방 ,  금교창 ,  장민석 ,  모길웅 ,  오희영

IPC: C12P17/12

Abstract: PURPOSE: Methods for preparing tetrasubstitued pyrazines using baker's yeast are provided, thereby easily and environment-friendly preparing tetrasubstitued pyrazines in water under mild condition. CONSTITUTION: The method for preparing tetrasubstitued pyrazines of formula (2) using baker's yeast comprises the steps of: (1) preparing a solution of baker's yeast; and (2) dissolving beta-keto alpha-oxime carbonyl derivatives of formula (1) in hydrophilic organic solvent and adding the solution into the baker's yeast solution to carry out chemoselective microbial reduction, wherein R1 is methyl, ethyl or phenyl; R2 is hydrogen, methyl or benzyl; R3 is methoxy, ethoxy, benzyloxy or phenylamine; the organic solvent is selected from benzene, toluene and hexane.

Abstract translation: 目的：提供使用面包酵母制备四取代吡嗪的方法，由此在温和条件下容易且环境友好地制备四取代吡嗪在水中。 构成：使用面包酵母制备式（2）的四取代吡嗪的方法包括以下步骤：（1）制备面包酵母溶液; （2）将式（1）的β-酮基α-肟羰基衍生物溶解于亲水性有机溶剂中，并将该溶液加入面包酵母溶液中进行化学选择性微生物还原，其中R1为甲基，乙基或苯基; R2是氢，甲基或苄基; R3是甲氧基，乙氧基，苄氧基或苯胺; 有机溶剂选自苯，甲苯和己烷。

公开(公告)号：KR1020040095889A

公开(公告)日：2004-11-16

申请号：KR1020030026907

申请日：2003-04-29

Applicant: 한국과학기술연구원

Inventor： 김유승 ,  강순방 ,  금교창 ,  장민석 ,  모길웅 ,  오희영

IPC: C12P17/12

Abstract: PURPOSE: Methods for preparing tetrasubstitued pyrazines using baker's yeast are provided, thereby easily and environment-friendly preparing tetrasubstitued pyrazines in water under mild condition. CONSTITUTION: The method for preparing tetrasubstitued pyrazines of formula (2) using baker's yeast comprises the steps of: (1) preparing a solution of baker's yeast; and (2) dissolving beta-keto alpha-oxime carbonyl derivatives of formula (1) in hydrophilic organic solvent and adding the solution into the baker's yeast solution to carry out chemoselective microbial reduction, wherein R1 is methyl, ethyl or phenyl; R2 is hydrogen, methyl or benzyl; R3 is methoxy, ethoxy, benzyloxy or phenylamine; the organic solvent is selected from benzene, toluene and hexane.

Abstract translation: 目的：提供使用面包酵母制备四取代吡嗪的方法，由此在温和条件下在水中制备四取代吡嗪容易且环境友好。 构成：使用面包酵母制备式（2）的四取代吡嗪的方法包括以下步骤：（1）制备面包酵母溶液; 将式（1）的β-酮基α-肟羰基衍生物溶解在亲水性有机溶剂中，并将溶液加入面包酵母溶液中进行化学选择性微生物还原，其中R1为甲基，乙基或苯基; R2是氢，甲基或苄基; R3是甲氧基，乙氧基，苄氧基或苯胺; 有机溶剂选自苯，甲苯和己烷。