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    1,6-이치환-3-아미노-4,5,6,7-테트라하이드로-1Ｈ-피라졸로［3,4-ｃ］피리딘-7-온 화합물 및 이 화합물의 제조방법
    1.
    发明公开
    1,6-이치환-3-아미노-4,5,6,7-테트라하이드로-1Ｈ-피라졸로［3,4-ｃ］피리딘-7-온 화합물 및 이 화합물의 제조방법 有权
    新的1,6-二异丙基氨基-4,5,6,7-四氢-1H-吡唑并[3,4-C]吡啶-7-酮化合物及其制备方法

    公开(公告)号：KR1020110139988A

    公开(公告)日：2011-12-30

    申请号：KR1020100060138

    申请日：2010-06-24

    Applicant: 한국과학기술연구원

    Inventor： 남길수 ,  배애님 ,  최경일 ,  추현아 ,  와니 ,  서선희

    IPC: C07D471/04 ,  C07D403/02 ,  A61K31/437 ,  A61P35/00

    CPC classification number: C07D471/04

    Abstract: PURPOSE: A novel 1,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-7-one is provided to suppress cancer cells. CONSTITUTION: A 1,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-7-one compound is denoted by chemical formula 1. A pharmaceutical composition for anticancer contains the compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. A method for preparing the compound of chemical formula 1 comprises a step of alkylating 3-amino compounds of chemical formula 2 with haloalkylcarbonyl piperazine of chemical formula 3 by alkylating.

    Abstract translation: 目的：提供新颖的1,6-二取代-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-7-酮以抑制癌细胞。 构成：1,6-二取代-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-7-酮化合物由化学式1表示。用于抗癌的药物组合物含有化合物 的化学式1或其药学上可接受的盐作为活性成分。 制备化学式1的化合物的方法包括通过烷基化将化学式2的3-氨基化合物与化学式3的卤代烷基羰基哌嗪烷基化的步骤。

    3,6-이치환-4,5,6,7-테트라하이드로-1Ｈ-피라졸로［3,4-ｃ］피리딘-7-온 화합물과 이 화합물의 제조방법
    2.
    发明公开
    3,6-이치환-4,5,6,7-테트라하이드로-1Ｈ-피라졸로［3,4-ｃ］피리딘-7-온 화합물과 이 화합물의 제조방법 有权
    新的3,6-取代-4,5,6,7-四氢-1H-吡唑并[3,4-C]吡啶-7-酮化合物及其制备方法

    公开(公告)号：KR1020110121868A

    公开(公告)日：2011-11-09

    申请号：KR1020100041360

    申请日：2010-05-03

    Applicant: 한국과학기술연구원 ,  서울대학교산학협력단

    Inventor： 남길수 ,  배애님 ,  최경일 ,  와니 ,  서선희 ,  추현아

    IPC: C07D471/02 ,  C07D487/04 ,  A61P35/00 ,  A61K31/437

    Abstract: PURPOSE: A novel 3,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one compound is provided to suppress cancer cell and to be used as an anticancer agent. CONSTITUTION: A 3,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one is denoted by chemical formula 1. A pharmaceutical composition for anticancer contains the compound of chemical formula 1 as an active ingredient. A method for preparing the compound of chemical formula 1 comprises: a step of performing acrylation of 3-amino compound of chemical formula 2 with acyl halide compound of chemical formula 3 to prepare 3-haloacylcarbamoyl compound of chemical formula 4; and a step of substituting 3-haloacylcarbamoyl compound of chemical formula 4 with amine compounds of chemical formula 5.

    Abstract translation: 目的：提供新的3,6-二取代-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-7-酮化合物以抑制癌细胞并用作抗癌剂 。 构成：3,6-二取代-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-7-酮由化学式1表示。用于抗癌的药物组合物含有 化学式1为活性成分。 制备化学式1化合物的方法包括：用化学式3的酰卤化合物进行化学式2的3-氨基化合物的丙烯酸化以制备化学式4的3-卤代酰基氨基甲酰基化合物的步骤; 和用化学式5的胺化合物代替化学式4的3-卤代酰基氨基甲酰基化合物的步骤。

    세로토닌 5-ＨＴ6 저해 활성을 갖는 5-설포닐아미노-5,6-다이하이드로-1Ｈ-피라졸로[3,4-ｃ]피리딘-7(4Ｈ)-온 화합물
    9.
    发明公开
    세로토닌 5-ＨＴ6 저해 활성을 갖는 5-설포닐아미노-5,6-다이하이드로-1Ｈ-피라졸로[3,4-ｃ]피리딘-7(4Ｈ)-온 화합물 有权
    新型5-磺酰氨基-5,6-二氢-1H-吡唑并[3,4-C]吡啶-7（4H） - 酮化合物，其具有丝氨酸5-HT6的抑制活性

    公开(公告)号：KR1020140118141A

    公开(公告)日：2014-10-08

    申请号：KR1020130033552

    申请日：2013-03-28

    Applicant: 한국과학기술연구원

    Inventor： 남길수 ,  추현아 ,  임혜원 ,  금교창 ,  와니

    IPC: C07D471/04 ,  A61K31/437 ,  A61P25/00

    Abstract: The present invention relates to a novel 5-sulfonylamino-5,6-dihydro-1H-pyrazolo[3,4-c]pyridin-7(4H)-one compound having an inhibitory activity for 5-HT6, which is one of serotonin subtypes, and a pharmaceutical composition comprising the compound as an active ingredient. Since the novel compound of the present invention has 5-HT6 inhibitory activities, the compound can be used for diagnosing, preventing, and treating central nervous system (CNS) diseases such as Alzheimer′s disease (AD), attention deficit disorder (ADHD), epilepsy, depression, obesity, schizophrenia, sleep disorders, and pain disorders.

    Abstract translation: 本发明涉及对5-HT6具有抑制活性的新的5-磺酰基氨基-5,6-二氢-1H-吡唑并[3,4-c]吡啶-7（4H） - 酮化合物，其为5-羟色胺 亚型和包含该化合物作为活性成分的药物组合物。 由于本发明的新化合物具有5-HT 6抑制活性，所以该化合物可用于诊断，预防和治疗中枢神经系统（CNS）疾病如阿尔茨海默病（AD），注意缺陷障碍（ADHD） ，癫痫，抑郁症，肥胖，精神分裂症，睡眠障碍和疼痛障碍。

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