N₂S₂ 리간드가 결합된 아릴피페라진 유도체 및 이의 제조방법
    6.
    发明公开
    N₂S₂ 리간드가 결합된 아릴피페라진 유도체 및 이의 제조방법 失效
    与N2S2配体连接的亚苄基衍生物及其制备方法

    公开(公告)号:KR1020000051075A

    公开(公告)日:2000-08-16

    申请号:KR1019990001313

    申请日:1999-01-18

    Abstract: PURPOSE: Arylpiperazine derivatives attached with an N2S2 ligand useful as an imaging compound for serotonin receptors and preparing process thereof are provided which have the advantage of labelling a technetium being free from amide hydrolysis and having high affinity with 5-HT1A. CONSTITUTION: A process for preparing tetrabenazine derivatives represented by the formula (1) comprises the steps of synthesizing arylpiperazine derivatives, synthesizing an N2S2 ligand and attaching the N2S2 ligand to the arylpiperazine derivatives. In formula, X denotes methoxy, trifluoromethyl, or chloro; Y denotes carbon or nitrogen; Z denotes carbon or nitrogen. The compound has the advantage of labeling a technetium having the radiochemically optimum physical conditions(manufacturing easiness, half-life period, radioactive strength and purchase easiness).

    Abstract translation: 目的:提供用作用作血清素受体成像化合物的N2S2配体附着的芳基哌嗪衍生物及其制备方法,其具有标记锝不含酰胺水解并且与5-HT1A具有高亲和力的优点。 构成:由式(1)表示的制备丁苯那嗪衍生物的方法包括合成芳基哌嗪衍生物,合成N 2 S 2配体并将N 2 S 2配体连接到芳基哌嗪衍生物的步骤。 在式中,X表示甲氧基,三氟甲基或氯; Y表示碳或氮; Z表示碳或氮。 该化合物具有标记具有放射化学最佳物理条件(制造容易度,半衰期,放射性强度和购买容易度)的锝的优点。

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