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1.发明公开
公开(公告)号：KR1020000026053A
公开(公告)日：2000-05-06
申请号：KR1019980043425
申请日：1998-10-17
Applicant: 한국과학기술연구원
CPC classification number: A61K36/57 , A61K31/34 , A61K2236/33 , A61K2236/51
Abstract: PURPOSE: A lignan compound isolated from magnolia floss or extract of magnolia floss having excellent inhibition activity for generation of leukotrienes is provided, which can be used as a medicine for various inflammatory disease like as asthma, whooping cough, arthritis, septic shock, ischemia, allergic rhinitis related with activity of leukotrienes. CONSTITUTION: A lignan compound is gained by the process of: extracting from magnolia floss using primary alcohol like as methanol; concentration; adding distilled water and hexane; isolating hexane layer; concentrating and adding ethylacetate; isolating ethylacetate layer; concentrating and separating by silicagel column chromatography; gaining dimethoxy aschantin of formula 1, aschantin of formula 2, fargesin from 8th part, and gaining pinoresinol dimethyl ether of formula 4, mandolin, liroresinol-B-dimethyl ether and (+)-epimandolin A from 11th part using reverse-phase silicagel column chromatography and high speed liquid column chromatography repeatedly.
Abstract translation: 目的：提供从木兰中分离的木脂素化合物或具有优异的白三烯产生抑制活性的木兰提取物，其可用作各种炎性疾病如哮喘，百日咳，关节炎，败血性休克，缺血， 过敏性鼻炎与白细胞三烯的活性有关。 构成：通过以下方法获得木脂素化合物：使用伯醇如甲醇从木兰提取; 浓度; 加入蒸馏水和己烷; 分离己烷层; 浓缩并加入乙酸乙酯; 分离乙酸乙酯层; 通过硅胶柱色谱法浓缩和分离; 获得式1的二甲氧基香豆素，式2的as子，第8部分的法尔金，第11部分使用反相硅胶柱，得到第4部分的式4的曼诺替林，间苯二酚-b-二甲醚和（+） - 表雌激素A 色谱法和高速液相色谱法反复进行。
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Patent Agency Ranking
公开(公告)号：KR1020010086473A
公开(公告)日：2001-09-12
申请号：KR1020010049577
申请日：2001-08-17
Applicant: 한국과학기술연구원
IPC: A61K31/05
Abstract: PURPOSE: Provided is a novel use of essential oil obtained by vapor distillation of plants and showing the inhibitory action against the production of leukotriene as a mediator of inflammation. CONSTITUTION: An inhibitor of leukotriene production comprises at least a compound selected from the group consisting of (-)-menthol, (+)-limonene, alpha-terpinene, gamma-terpinene, terpineol, beta-myrcene, (±)-linaloo, geraniol, citral, beta-cyclocitral, eugenol, safrole, (+)-alpha-pinene, (-)-alpha-pinene, and (+)-cis-verbenol, as an effective components. Preferably, the inhibitor comprises eugenol or safrole as an active ingredient. The inhibitor can be used for a variety of inflammatory diseases including asthma, whooping cough, psoriasis, arthritis, inflammatory intestine diseases, cystic fibrosis, chronic bronchitis, rheumatoid arthritis, septic shock, myocardial ischemia, cardiac anaphylaxis, cerebral vasospasm, ischemia and allergic rhinitis.
Abstract translation: 目的：提供通过蒸汽蒸馏植物获得的精油的新用途，并显示出作为炎症介质产生白三烯的抑制作用。 构型：白三烯生产抑制剂包括至少一种选自（ - ） - 薄荷醇，（+） - 柠檬烯，α-萜品烯，γ-萜品烯，萜品醇，β-月桂烯，（±）-Linaloo， 香叶醇，柠檬醛，β-环萜烯，丁子香酚，黄樟脑，（+） - 蒎烯，（ - ） - 蒎烯和（+） - 顺式 - 马鞭草醇作为有效成分。 优选地，抑制剂包括丁子香酚或黄樟脑作为活性成分。 抑制剂可用于各种炎性疾病，包括哮喘，百日咳，牛皮癣，关节炎，炎性肠病，囊性纤维化，慢性支气管炎，类风湿性关节炎，败血性休克，心肌缺血，心脏过敏反应，脑血管痉挛，局部缺血和过敏性鼻炎 。
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公开(公告)号：KR100372562B1
公开(公告)日：2003-02-15
申请号：KR1020010049577
申请日：2001-08-17
Applicant: 한국과학기술연구원
IPC: A61K31/05
Abstract: PURPOSE: Provided is a novel use of essential oil obtained by vapor distillation of plants and showing the inhibitory action against the production of leukotriene as a mediator of inflammation. CONSTITUTION: An inhibitor of leukotriene production comprises at least a compound selected from the group consisting of (-)-menthol, (+)-limonene, alpha-terpinene, gamma-terpinene, terpineol, beta-myrcene, (±)-linaloo, geraniol, citral, beta-cyclocitral, eugenol, safrole, (+)-alpha-pinene, (-)-alpha-pinene, and (+)-cis-verbenol, as an effective components. Preferably, the inhibitor comprises eugenol or safrole as an active ingredient. The inhibitor can be used for a variety of inflammatory diseases including asthma, whooping cough, psoriasis, arthritis, inflammatory intestine diseases, cystic fibrosis, chronic bronchitis, rheumatoid arthritis, septic shock, myocardial ischemia, cardiac anaphylaxis, cerebral vasospasm, ischemia and allergic rhinitis.
Abstract translation: 目的：提供一种通过蒸馏植物而获得的精油的新用途，并显示出对作为炎症介质的白三烯产生的抑制作用。 （ - ） - 薄荷醇，（+） - 柠檬烯，α-萜品烯，γ-萜品烯，萜品醇，β-月桂烯，（+）; （+） - α-蒎烯，（ - ） - α-蒎烯，和（+） - 顺式 - 马鞭草醇为有效成分。 优选地，抑制剂包含丁香酚或黄樟素作为活性成分。 该抑制剂可用于哮喘，百日咳，牛皮癣，关节炎，炎性肠疾病，囊性纤维化，慢性支气管炎，类风湿性关节炎，感染性休克，心肌缺血，心脏过敏反应，脑血管痉挛，局部缺血和过敏性鼻炎 。
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公开(公告)号：KR100355497B1
公开(公告)日：2002-12-28
申请号：KR1019980055981
申请日：1998-12-18
Applicant: 한국과학기술연구원
IPC: A61K31/035
Abstract: 본 발명은 정유 (精油; essential oil)를 유효성분으로 함유하는 류코트리엔 생성 저해제용 약학적 조성물에 관한 것으로, 보다 상세하게는 주성분으로 (-)-멘틀 (menthol; 화학식 1), (+)-리모넨 (limonene; 화학식 2),
α -테르피넨 (terplnelle; 화학식 3),
r -테르피넨 (terpinene; 화학식 4), 테르퍼네올 (terpineol; 화학식 5),
β -미르센 (myrcene; 화학식 6), (±)-리나룰 (linalool; 화학식 7), 게라니올 (geraniol; 화학식 8), 사이트랄 (citral; 화학식 9),
β -사이클로사이트랄 (cyclocitral; 화학식 10), 유게놀 (eugenol; 화학식 11), 사프롤 (safrole; 화학식 12), (+)-
α -피넨 (pinene; 화학식 13), (-)-
α -피넨 (pinene; 화학식 14) 및 (+)-
cis -베르베놀 (verbenol; 화학식 15) 중에서 선택되는 하나 이상의 화합물을 포함하는 조성물은 류코트리엔 생성 저해제로서 류코트리엔과 관련된 질환의 예방, 치료 및 치료보조제 로 유용하게 사용될 수 있다.-
公开(公告)号：KR100321313B1
公开(公告)日：2002-08-13
申请号：KR1019980043425
申请日：1998-10-17
Applicant: 한국과학기술연구원
Abstract: 본 발명은 류코트리엔 생성 저해활성을 가지는 신이 (Magnoliae flos) 추출물 및 신이로부터 분리한 리그난 화합물에 관한 것으로, 신이를 유기용매로 추출하여 얻어지는 본 발명의 신이 추출물 및 이로부터 분리되는 하기 화학식 1 내지 화학식 7의 리그난 화합물은 류코트리엔 생성 저해제로서 류코트리엔과 관련된 질환의 예방, 치료 및 치료보조제로 유용하게 사용될 수 있다.
[화학식 1]
[화학식 2]
[화학식 3]
[화학식 4]
[화학식 5]
[화학식 6]
[화학식 7]-
公开(公告)号：KR1020000040361A
公开(公告)日：2000-07-05
申请号：KR1019980055981
申请日：1998-12-18
Applicant: 한국과학기술연구원
IPC: A61K31/035
Abstract: PURPOSE: A pharmaceutical composition containing essential oil as an active principle for inhibiting production of leukotriene is useful for prevention and treatment of the diseases related with the activity of leukotriene such as asthma, cystic fibrosis, septic shock, cardiac anaphylaxis, cerebral vasospasm, psoriasis, endotoxemia, myocardial ischemia, etc.. CONSTITUTION: A main component of the essential oil is more than one compound selected from (-)-menthol, (+)-limonene, alpha-terpinene, gamma-terpinene, terpineol, beta-myrcene, (+or-)-linalool, geraniol, citral, beta-cyclocitral, eugenol, safrol, (+)-alpha-pinene, (-)-alpha-pinene and (+)-cis-verbenol.
Abstract translation: 目的：含有精油作为抑制白细胞三烯生成的活性成分的药物组合物可用于预防和治疗与白细胞三烯的活性有关的疾病，例如哮喘，囊性纤维化，败血性休克，心脏过敏反应，脑血管痉挛，牛皮癣， 内毒素血症，心肌缺血等。组成：精油的主要成分是选自（ - ） - 薄荷醇，（+） - 柠檬烯，α-萜品烯，γ-萜品烯，萜品醇，β-月桂烯， （+或 - ） - 芳樟醇，香叶醇，柠檬醛，β-环咔唑，丁子香酚，safrol，（+） - 蒎烯，（ - ） - 蒎烯和（+） - 顺式 -
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