-
公开(公告)号：KR100372562B1
公开(公告)日：2003-02-15
申请号：KR1020010049577
申请日：2001-08-17
Applicant: 한국과학기술연구원
IPC: A61K31/05
Abstract: PURPOSE: Provided is a novel use of essential oil obtained by vapor distillation of plants and showing the inhibitory action against the production of leukotriene as a mediator of inflammation. CONSTITUTION: An inhibitor of leukotriene production comprises at least a compound selected from the group consisting of (-)-menthol, (+)-limonene, alpha-terpinene, gamma-terpinene, terpineol, beta-myrcene, (±)-linaloo, geraniol, citral, beta-cyclocitral, eugenol, safrole, (+)-alpha-pinene, (-)-alpha-pinene, and (+)-cis-verbenol, as an effective components. Preferably, the inhibitor comprises eugenol or safrole as an active ingredient. The inhibitor can be used for a variety of inflammatory diseases including asthma, whooping cough, psoriasis, arthritis, inflammatory intestine diseases, cystic fibrosis, chronic bronchitis, rheumatoid arthritis, septic shock, myocardial ischemia, cardiac anaphylaxis, cerebral vasospasm, ischemia and allergic rhinitis.
Abstract translation: 目的：提供一种通过蒸馏植物而获得的精油的新用途，并显示出对作为炎症介质的白三烯产生的抑制作用。 （ - ） - 薄荷醇，（+） - 柠檬烯，α-萜品烯，γ-萜品烯，萜品醇，β-月桂烯，（+）; （+） - α-蒎烯，（ - ） - α-蒎烯，和（+） - 顺式 - 马鞭草醇为有效成分。 优选地，抑制剂包含丁香酚或黄樟素作为活性成分。 该抑制剂可用于哮喘，百日咳，牛皮癣，关节炎，炎性肠疾病，囊性纤维化，慢性支气管炎，类风湿性关节炎，感染性休克，心肌缺血，心脏过敏反应，脑血管痉挛，局部缺血和过敏性鼻炎 。
-
公开(公告)号：KR1020000001978A
公开(公告)日：2000-01-15
申请号：KR1019980022501
申请日：1998-06-16
Applicant: 한국과학기술연구원
IPC: C07H21/00
Abstract: PURPOSE: A compound, tylinoside, having an anticomplement activity is isolated from Magnolia flos and the structure thereof is examined by spectroscopy. CONSTITUTION: Tylinoside of formula (I) is isolated from Magnolia floes and the pharmaceutical composition, containing the isolated compound of formula (I) as an effective ingredient of complement activity regulating agent, is prepared. Thus, Magnolia flos is crushed and extracted with methanol and the filtrated liquid is vacuum concentrated, suspended in distilled water, and extracted with ethylacetate. The extracts are fractionated with silica gel column chromatography to isolate the tylinoside of formula (I).
Abstract translation: 目的：从玉兰中分离出具有抗补体活性的化合物泰勒糖苷，通过光谱法检测其结构。 构成：制备式（I）的泰洛糖苷从玉兰絮状物中分离出来，制备含有分离的式（I）化合物作为补体活性调节剂的有效成分的药物组合物。 因此，将玉兰粉碎并用甲醇萃取，将滤液真空浓缩，悬浮于蒸馏水中，用乙酸乙酯萃取。 萃取液用硅胶柱色谱分离，分离出式（I）的泰勒糖苷。
-
-
-
公开(公告)号：KR100370884B1
公开(公告)日：2003-12-01
申请号：KR1019980022501
申请日：1998-06-16
Applicant: 한국과학기술연구원
IPC: C07H21/00
Abstract: PURPOSE: A compound, tylinoside, having an anticomplement activity is isolated from Magnolia flos and the structure thereof is examined by spectroscopy. CONSTITUTION: Tylinoside of formula (I) is isolated from Magnolia floes and the pharmaceutical composition, containing the isolated compound of formula (I) as an effective ingredient of complement activity regulating agent, is prepared. Thus, Magnolia flos is crushed and extracted with methanol and the filtrated liquid is vacuum concentrated, suspended in distilled water, and extracted with ethylacetate. The extracts are fractionated with silica gel column chromatography to isolate the tylinoside of formula (I).
Abstract translation: 目的：从Magnolia flos分离具有抗补体活性的化合物，tylinoside，并通过光谱检查其结构。 构成：从Magnolia絮凝物中分离式（I）的Tylinoside，并制备含有分离的式（I）化合物作为补体活性调节剂的有效成分的药物组合物。 因此，将白玉兰花粉碎并用甲醇萃取，将过滤的液体真空浓缩，悬浮于蒸馏水中，并用乙酸乙酯萃取。 将提取物用硅胶柱色谱分离以分离式（I）的泰瑞诺苷。
-
Patent Agency Ranking6.发明公开
公开(公告)号：KR1020000026053A
公开(公告)日：2000-05-06
申请号：KR1019980043425
申请日：1998-10-17
Applicant: 한국과학기술연구원
CPC classification number: A61K36/57 , A61K31/34 , A61K2236/33 , A61K2236/51
Abstract: PURPOSE: A lignan compound isolated from magnolia floss or extract of magnolia floss having excellent inhibition activity for generation of leukotrienes is provided, which can be used as a medicine for various inflammatory disease like as asthma, whooping cough, arthritis, septic shock, ischemia, allergic rhinitis related with activity of leukotrienes. CONSTITUTION: A lignan compound is gained by the process of: extracting from magnolia floss using primary alcohol like as methanol; concentration; adding distilled water and hexane; isolating hexane layer; concentrating and adding ethylacetate; isolating ethylacetate layer; concentrating and separating by silicagel column chromatography; gaining dimethoxy aschantin of formula 1, aschantin of formula 2, fargesin from 8th part, and gaining pinoresinol dimethyl ether of formula 4, mandolin, liroresinol-B-dimethyl ether and (+)-epimandolin A from 11th part using reverse-phase silicagel column chromatography and high speed liquid column chromatography repeatedly.
Abstract translation: 目的：提供从木兰中分离的木脂素化合物或具有优异的白三烯产生抑制活性的木兰提取物，其可用作各种炎性疾病如哮喘，百日咳，关节炎，败血性休克，缺血， 过敏性鼻炎与白细胞三烯的活性有关。 构成：通过以下方法获得木脂素化合物：使用伯醇如甲醇从木兰提取; 浓度; 加入蒸馏水和己烷; 分离己烷层; 浓缩并加入乙酸乙酯; 分离乙酸乙酯层; 通过硅胶柱色谱法浓缩和分离; 获得式1的二甲氧基香豆素，式2的as子，第8部分的法尔金，第11部分使用反相硅胶柱，得到第4部分的式4的曼诺替林，间苯二酚-b-二甲醚和（+） - 表雌激素A 色谱法和高速液相色谱法反复进行。
-
公开(公告)号：KR1019950009319B1
公开(公告)日：1995-08-19
申请号：KR1019920001690
申请日：1992-02-06
Applicant: 한국과학기술연구원
IPC: C12P13/10
Abstract: L-ornithine is prepared from L-arginine by enzymatic reaction with arginase and urease as composite enzyme at 25-40 deg.C and pH 7-8. And arginase and urease can be immobilized by adsorption on support such as amberlite, chitin, cellite, and glyceril-CPG. The production yield is enhanced above 97%, and when operating in a packed bed reactor using this method, the enzyme acitivity is kept longer than 6 days.
Abstract translation: L-精氨酸由L-精氨酸通过与精氨酸酶和脲酶作为复合酶在25-40℃和pH7-8下进行酶反应制备。 精氨酸酶和脲酶可以通过在载体上的吸附来固定，如琥珀酸，甲壳素，细胞岩和甘油-CPG。 生产产率提高到97％以上，当使用该方法在填充床反应器中操作时，酶活性保持长于6天。
-
公开(公告)号：KR1020010086473A
公开(公告)日：2001-09-12
申请号：KR1020010049577
申请日：2001-08-17
Applicant: 한국과학기술연구원
IPC: A61K31/05
Abstract: PURPOSE: Provided is a novel use of essential oil obtained by vapor distillation of plants and showing the inhibitory action against the production of leukotriene as a mediator of inflammation. CONSTITUTION: An inhibitor of leukotriene production comprises at least a compound selected from the group consisting of (-)-menthol, (+)-limonene, alpha-terpinene, gamma-terpinene, terpineol, beta-myrcene, (±)-linaloo, geraniol, citral, beta-cyclocitral, eugenol, safrole, (+)-alpha-pinene, (-)-alpha-pinene, and (+)-cis-verbenol, as an effective components. Preferably, the inhibitor comprises eugenol or safrole as an active ingredient. The inhibitor can be used for a variety of inflammatory diseases including asthma, whooping cough, psoriasis, arthritis, inflammatory intestine diseases, cystic fibrosis, chronic bronchitis, rheumatoid arthritis, septic shock, myocardial ischemia, cardiac anaphylaxis, cerebral vasospasm, ischemia and allergic rhinitis.
Abstract translation: 目的：提供通过蒸汽蒸馏植物获得的精油的新用途，并显示出作为炎症介质产生白三烯的抑制作用。 构型：白三烯生产抑制剂包括至少一种选自（ - ） - 薄荷醇，（+） - 柠檬烯，α-萜品烯，γ-萜品烯，萜品醇，β-月桂烯，（±）-Linaloo， 香叶醇，柠檬醛，β-环萜烯，丁子香酚，黄樟脑，（+） - 蒎烯，（ - ） - 蒎烯和（+） - 顺式 - 马鞭草醇作为有效成分。 优选地，抑制剂包括丁子香酚或黄樟脑作为活性成分。 抑制剂可用于各种炎性疾病，包括哮喘，百日咳，牛皮癣，关节炎，炎性肠病，囊性纤维化，慢性支气管炎，类风湿性关节炎，败血性休克，心肌缺血，心脏过敏反应，脑血管痉挛，局部缺血和过敏性鼻炎 。
-
公开(公告)号：KR100252194B1
公开(公告)日：2000-04-15
申请号：KR1019970051930
申请日：1997-10-10
Applicant: 한국과학기술연구원
IPC: A61K31/732 , A61K36/232
CPC classification number: C08B37/0045 , A61K31/715 , C08B37/00
Abstract: PURPOSE: A novel pectin polysaccharides(Angellan-I, Angellan-II) separated from Angelica gigas Nakai is provided, which contains galacturonic acid, arabinose and galactose, therefore shows immune-increasing effect and also can be used as an immune-increasing reagent in the basic study for immunology. CONSTITUTION: A process for the separation of novel pectin polysaccharides(Angellan-I, Angellan-II) from Angelica gigas Nakai comprises the steps of: pulverizing Angelica gigas Nakai root into pieces, adding water and extracting while circulating at 100deg.C for 1hr; adding 3times of ethanol to the residual solution, leaving at 4deg.C for 3hrs and centrifuging to get extracted precipitates; dissolving the ethanol extract in water to remove impurities, adding 3times of ethanol to the residual solution again, centrifuging and processing dialysis; freeze-drying the reagent to get crude polysaccharides; and separating the crude polysaccharides into acidic polysaccharides(Angellan I) and neutral polysaccharides(Angellan II) by dissolving, washing, centrifuging, doing dialysis and freeze-drying.
Abstract translation: 目的：提供从当归纳西分离的新型果胶多糖（Angellan-I，Angellan-II），其含有半乳糖醛酸，阿拉伯糖和半乳糖，因此具有免疫增加作用，并且还可用作免疫增加试剂 免疫学的基础研究。 构成：从当归Nakai中分离出新型果胶多糖（Angellan-I，Angellan-II）的方法，包括以下步骤：将当归Nakai根粉碎成片，加水并在100℃循环提取1小时; 向剩余溶液中加入3倍的乙醇，在4℃下放置3h，离心得到提取的沉淀物; 将乙醇提取液溶解于水中去除杂质，再次向剩余溶液中加入3倍乙醇，离心和加工透析液; 冷冻干燥试剂得到粗多糖; 并通过溶解，洗涤，离心，进行透析和冷冻干燥将粗多糖分离成酸性多糖（Angellan I）和中性多糖（Angellan II）。
-
公开(公告)号：KR1019990031277A
公开(公告)日：1999-05-06
申请号：KR1019970051930
申请日：1997-10-10
Applicant: 한국과학기술연구원
IPC: A61K31/732 , A61K36/232
Abstract: 본 발명은 참당귀(Angelica gigas Nakai)로 부터 분리한 펙틴질 다당인 안젤란-I과 안젤란-II 등의 물질, 이들의 순수분리방법 및 이들의 항암제 또는 면역증강제로서의 용도에 관한 것이다. 더욱 상세하게는 참당귀에서 분리한 갈락트론산, 아라비노스, 그리고 갈락토스 등을 함유하는 면역증강제의 조성물 이온교환수지를 사용하는 이들물질의 분리 정제하는 방법, 이들 물질의 암을 포함한 면역관련질환의 예방, 치료, 및 치료후의 면역증강을 위한 약물로서의 이용에 관한 것, 이들물질의 면역학 기초연구를 위한 면역증강 시료로서의 이용에 관한 것이다.
-
-
-
-
-
-
-
-
-
Search Results
15
records
(took 0.019 seconds)
