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公开(公告)号：KR101179081B1
公开(公告)日：2012-09-03
申请号：KR1020110012517
申请日：2011-02-11
Applicant: 한국과학기술연구원
Abstract: 본 발명에 따른 맞춤형 인공삽입물 설계 방법은 2D로 촬영된 뼈 이미지를 이용하여 3D(Three Dimensions) 영상을 생성하는 단계와; 상기 2D 뼈 이미지를 이용하여 골밀도 정보를 측정하는 단계와; 상기 골밀도 정보를 상기 3D 영상에 색채화하는 단계와; 상기 색채화된 3D 영상을 이용하여, 인공 삽입물을 설계하기 위한 인공삽입물의 크기, 위치, 골고정 나사 구멍의 위치 값을 산출하는 단계를 포함할 수 있다.
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公开(公告)号：KR1020120092451A
公开(公告)日：2012-08-21
申请号：KR1020110012517
申请日：2011-02-11
Applicant: 한국과학기술연구원
Abstract: PURPOSE: An apparatus for designing custom-made prosthesis based on bone density measurement is provided to supply the position information of a bone fixing screw and the design variable of the prosthesis by restructuring a 3D image having visualized bone density information. CONSTITUTION: An image processing device(200) performs a CT image input stage(S210). A contour line is detected according to a threshold value(S220). The bone density is measured and a color map is set according to the distribution of the bone density(S230). The image processing device performs a 3D bone image recomposition stage(S240). The bone density is visualized on the 3D bone image(S250). A design device(300) decides the insertion position and the size of the prosthesis using the 3D bone image(S310). The location, the size and the number of bone fixing screws are determined(S320). The design device accurately designs the prosthesis for a patient(S330).
Abstract translation: 目的：提供一种用于设计基于骨密度测量的定制假体的装置，通过重构具有可视化骨密度信息的3D图像来提供骨固定螺钉的位置信息和假体的设计变量。 构成：图像处理装置（200）进行CT图像输入级（S210）。 根据阈值检测轮廓线（S220）。 测定骨密度，根据骨密度的分布设定颜色图（S230）。 图像处理装置执行3D骨骼图像重构阶段（S240）。 骨密度在3D骨图像上可视化（S250）。 设计装置（300）使用3D骨骼图像来决定假体的插入位置和尺寸（S310）。 确定骨固定螺钉的位置，尺寸和数量（S320）。 设计装置准确地为患者设计假体（S330）。
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公开(公告)号：KR101270161B1
公开(公告)日：2013-05-31
申请号：KR1020100038221
申请日：2010-04-26
Applicant: 한국과학기술연구원
CPC classification number: C12N5/0075 , A61K9/1647 , A61K9/5036 , C12N2533/40
Abstract: 본발명은세포분화및 증식에필수적인생리활성성장인자를담지할수 있는전달체의제조방법에관한것으로, 성장인자를포함한 2종의성분을하나의캐리어에담지함으로서복수의성장인자들이개별적으로시차를두고방출(temporally controlled release)될수 있는구조로고안된것이특징이다. 구체적으로, (1) 제1 성분을담지한고분자미립구(microsphere)를제조하고나서, 상기고분자미립구를전기적하(electrodropping)방식으로제2 성분이포함된다른고분자층에도입(encapsulation)하여코어-쉘구조를가진마이크로캡슐형태의전달체를제조하는단계, 또는 (2) 제1 성분을담지한고분자용액을전기적하방식으로제2 성분이포함된다른고분자내에도입하여마이크로캡슐형태의전달체를제조하는단계를포함한다. 본발명은또한, 본발명에따른복수의성장인자를담지한마이크로캡슐형전달체를줄기세포와접촉시키는단계를포함하는줄기세포분화방법을제공한다.
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公开(公告)号：KR1020110118859A
公开(公告)日：2011-11-02
申请号：KR1020100038221
申请日：2010-04-26
Applicant: 한국과학기술연구원
CPC classification number: C12N5/0075 , A61K9/1647 , A61K9/5036 , C12N2533/40
Abstract: PURPOSE: A method for preparing a delivery system for supporting physiologically active growth factors which are necessary for cell differentiation and proliferation is provided to maximize stem cell differentiation ability in vitro. CONSTITUTION: A growth factor delivery system comprises a core and shell structure containing two kinds of ingredients which are necessary for cell differentiation or proliferation. The delivery system is in the form of a microsphere of 100-400 um in dianeter. The delivery system is treated with a crosslinking agent of ethyl dimethyl amino propyl carbodiimide, genipin, or glutaraldehyde in the shell. A method for preparing the delivery system comprises: a step of preparing a polymeric microsphere containing a first ingredient needed for cell differentiation or proliferation; and a step of introducing the polymeric microsphere into other polymers containing a second ingredient needed for cell differentiation or proliferation.
Abstract translation: 目的：提供一种用于制备支持细胞分化和增殖所必需的生理活性生长因子的递送系统的方法，以使体外干细胞分化能力最大化。 构成：生长因子递送系统包括含有细胞分化或增殖所必需的两种成分的核心和壳结构。 递送系统为dianeter中100-400微米的微球形式。 递送系统在壳中用乙基二甲基氨基丙基碳二亚胺，天鹅蛋白或戊二醛的交联剂处理。 制备递送系统的方法包括：制备含有细胞分化或增殖所需的第一成分的聚合物微球的步骤; 以及将聚合物微球引入含有细胞分化或增殖所需的第二成分的其它聚合物的步骤。
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