公开(公告)号：KR100447943B1

公开(公告)日：2004-09-08

申请号：KR1020000065664

申请日：2000-11-06

Applicant: 한국과학기술연구원

Inventor： 유연규 ,  김기선 ,  진봉석

IPC: A61K38/03

CPC classification number: A61K38/10

Abstract: The present invention relates to peptides that can inhibit the infection of HIV, and more particularly, to peptides consisting of less than 30 amino acids which can introduce a helix capping motif into a peptide derived from C-terminal helical region (its 628-646th amino acid region) of gp41, an envelope glycoprotein of HIV, as well as consisting of the symmetrical bivalent peptide through the introduction of a branched amino acid, Fmoc-Lys(Fmoc)-OH at C-terminus of its peptide, and induce a more stable helical structure thus inhibiting the infection of HIV.

Abstract translation: 本发明涉及能够抑制HIV感染的肽，更具体地涉及由少于30个氨基酸组成的肽，其可以将螺旋帽基序引入衍生自C端螺旋区（其第628-646位氨基酸 通过在其肽的C-末端引入支链氨基酸Fmoc-Lys（Fmoc）-OH，并诱导更多的gp41（一种HIV的包膜糖蛋白），以及由对称二价肽组成 稳定的螺旋结构从而抑制HIV的感染。

公开(公告)号：KR1020020035399A

公开(公告)日：2002-05-11

申请号：KR1020000065664

申请日：2000-11-06

Applicant: 한국과학기술연구원

Inventor： 유연규 ,  김기선 ,  진봉석

IPC: A61K38/03

CPC classification number: A61K38/10

Abstract: PURPOSE: A peptide for inhibiting HIV infection is provided, which peptide can inhibit the cell fusion of HIV, can be cheaply and easily prepared since it consists of 30 or less of amino acids, and does not need the additional modification for use. CONSTITUTION: The peptide for inhibiting HIV infection comprises an Helix-capping motif peptide capable of binding with 19 amino acids of C-terminal region(amino acids 628 to 646) of gp41 which is a cell membrane fusion protein of HIV, in which the Helix-capping motif peptide has the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 3; the 19 amino acids of C-terminal region of gp41 has the amino acid sequence selected from SEQ ID NO: 4, SEQ ID NO: 5 and SEQ ID NO: 6; and the peptide for inhibiting the infection of HIV has the amino acid sequence selected from SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, and SEQ ID NO: 13.

Abstract translation: 目的：提供用于抑制HIV感染的肽，该肽可以抑制HIV的细胞融合，因为其由30个或更少的氨基酸组成，因此可以廉价且容易地制备，并且不需要额外的修饰用途。 构成：用于抑制HIV感染的肽包括能够与作为HIV的细胞膜融合蛋白的gp41的C-末端区域（氨基酸628至646）的19个氨基酸结合的螺旋封闭基序肽，其中螺旋 起始基序肽具有SEQ ID NO：2或SEQ ID NO：3的氨基酸序列; gp41的C-末端区域的19个氨基酸具有选自SEQ ID NO：4，SEQ ID NO：5和SEQ ID NO：6的氨基酸序列; 并且用于抑制HIV感染的肽具有选自SEQ ID NO：7，SEQ ID NO：8，SEQ ID NO：9，SEQ ID NO：10，SEQ ID NO：11，SEQ ID NO： 12和SEQ ID NO：13。