公开(公告)号：KR100324621B1

公开(公告)日：2002-02-27

申请号：KR1019990015016

申请日：1999-04-27

Applicant: 한국과학기술연구원

Inventor： 김충섭 ,  서재홍 ,  전제호 ,  장사정 ,  황동진 ,  차기석

IPC: C07D413/14 ,  A61K31/42

Abstract: 다음화학식 1을갖는, 퀴놀론이치환된옥사졸리디논유도체및 그의약제학적으로허용되는염을제공하며: 또한, 그의제조방법및 이를함유하는항균제조성물을제공한다.

公开(公告)号：KR1020000067306A

公开(公告)日：2000-11-15

申请号：KR1019990015016

申请日：1999-04-27

Applicant: 한국과학기술연구원

Inventor： 김충섭 ,  서재홍 ,  전제호 ,  장사정 ,  황동진 ,  차기석

IPC: C07D413/14 ,  A61K31/42

Abstract: PURPOSE: Quinolone substituted oxazolidinone capable of exhibiting an excellent antibacterial activity against resistant bacteria as a characteristic of an oxazolidinone antibacterial agent as well as maintaining a wide range of antibacterial activities of quinolone antibacterial agent, process for producing the same and their use as an antibacterial agent are provided which can be effectively used in the treatment of infectious diseases such as various bacterial infections. CONSTITUTION: Quinolone substituted oxazolidinone of formula 1 and pharmaceutically acceptable salts thereof, which has strong antibacterial activity against existing betalactam, quinolone, vancomycin as well as having a wide range of antibacterial activities against gram-positive and gram-negative bacteria and Pseudomonas bacteria are described. In formula, R1, R2, R4, R5, X and Y are defined in the description.

Abstract translation: 目的：喹诺酮取代的恶唑烷酮能够表现出对抗性细菌的优良抗菌活性，作为恶唑烷酮抗菌剂的特征，以及维持喹诺酮抗菌剂的广泛抗菌活性，其制备方法及其作为抗菌剂的用途 可以有效地用于治疗感染性疾病如各种细菌感染。 描述：描述了式1的喹诺酮取代的恶唑烷酮及其药学上可接受的盐，其对现有的β-内酰胺，喹诺酮，万古霉素以及对革兰氏阳性和革兰氏阴性菌和假单胞菌具有广泛的抗菌活性具有很强的抗菌活性 。 在式中，R1，R2，R4，R5，X和Y在说明书中定义。