公开(公告)号：KR100324621B1

公开(公告)日：2002-02-27

申请号：KR1019990015016

申请日：1999-04-27

Applicant: 한국과학기술연구원

Inventor： 김충섭 ,  서재홍 ,  전제호 ,  장사정 ,  황동진 ,  차기석

IPC: C07D413/14 ,  A61K31/42

Abstract: 다음화학식 1을갖는, 퀴놀론이치환된옥사졸리디논유도체및 그의약제학적으로허용되는염을제공하며: 또한, 그의제조방법및 이를함유하는항균제조성물을제공한다.

公开(公告)号：KR100917039B1

公开(公告)日：2009-09-10

申请号：KR1020070053068

申请日：2007-05-31

Applicant: 한국과학기술연구원

Inventor： 이소하 ,  배애님 ,  임혜원 ,  서선희 ,  정세진 ,  김준석 ,  전제호

IPC: C07D249/12

Abstract: 본 발명은 T-형 칼슘 채널(T-type calcium channel)을 억제하는 효과가 우수하여 간질과 같은 뇌질환, 협심증, 고혈압, 심근경색과 같은 심장질환, 신경성 통증, 그리고 암 등 다양한 종류의 질환을 치료 및 예방에 유용한 트리아졸 유도체와 이 화합물을 포함하는 약제 조성물에 관한 것이다.
트리아졸 유도체, T-형 칼슘 채널, 협심증, 고혈압, 심근경색, 통증, 간질 및 암

公开(公告)号：KR1020080105463A

公开(公告)日：2008-12-04

申请号：KR1020070053068

申请日：2007-05-31

Applicant: 한국과학기술연구원

Inventor： 이소하 ,  배애님 ,  임혜원 ,  서선희 ,  정세진 ,  김준석 ,  전제호

IPC: C07D249/12

Abstract: A triazole derivative useful as a T-type calcium channel blocker, and a pharmaceutical composition containing the derivative rae provided to inhibit the calcium channel of cell membranes, thereby preventing and treating the diseases such as brain disease, heart disease, neurogenic pain and cancer disease. A triazole derivative is represented by the formula 1, wherein R1 is phenyl group, a benzimidazole group, or a benzimidazole C1-C8 alkyl group; R2 is H, a C1-C8 alkyl group, a C1-C20 alkanoyl group, a phenyl group, a benzoyl group, or a thiophenecarbonyl group; R3 is H, or an N-phenylacetamide group; and the benzene ring of a phenyl group, a benzoyl group, a benzimidazole group and an N-phenylacetamide group can be substituted with 1-4 substituents selected from a halogen atom, a nitro group, a C1-C8 alkyl group, a C1-C8 alkoxy group and a C1-C8 haloalkyl group.

Abstract translation: 可用作T型钙通道阻断剂的三唑衍生物和含有衍生物的药物组合物，其用于抑制细胞膜的钙通道，从而预防和治疗脑疾病，心脏病，神经源性疼痛和癌症疾病 。 三唑衍生物由式1表示，其中R1是苯基，苯并咪唑基或苯并咪唑C1-C8烷基; R2是H，C1-C8烷基，C1-C20烷酰基，苯基，苯甲酰基或噻吩羰基; R3是H或N-苯基乙酰胺基团; 苯基，苯甲酰基，苯并咪唑基和N-苯基乙酰胺基的苯环可以被1-4个选自卤素原子，硝基，C1-C8烷基，C1- C8烷氧基和C1-C8卤代烷基。

公开(公告)号：KR1020000067306A

公开(公告)日：2000-11-15

申请号：KR1019990015016

申请日：1999-04-27

Applicant: 한국과학기술연구원

Inventor： 김충섭 ,  서재홍 ,  전제호 ,  장사정 ,  황동진 ,  차기석

IPC: C07D413/14 ,  A61K31/42

Abstract: PURPOSE: Quinolone substituted oxazolidinone capable of exhibiting an excellent antibacterial activity against resistant bacteria as a characteristic of an oxazolidinone antibacterial agent as well as maintaining a wide range of antibacterial activities of quinolone antibacterial agent, process for producing the same and their use as an antibacterial agent are provided which can be effectively used in the treatment of infectious diseases such as various bacterial infections. CONSTITUTION: Quinolone substituted oxazolidinone of formula 1 and pharmaceutically acceptable salts thereof, which has strong antibacterial activity against existing betalactam, quinolone, vancomycin as well as having a wide range of antibacterial activities against gram-positive and gram-negative bacteria and Pseudomonas bacteria are described. In formula, R1, R2, R4, R5, X and Y are defined in the description.

Abstract translation: 目的：喹诺酮取代的恶唑烷酮能够表现出对抗性细菌的优良抗菌活性，作为恶唑烷酮抗菌剂的特征，以及维持喹诺酮抗菌剂的广泛抗菌活性，其制备方法及其作为抗菌剂的用途 可以有效地用于治疗感染性疾病如各种细菌感染。 描述：描述了式1的喹诺酮取代的恶唑烷酮及其药学上可接受的盐，其对现有的β-内酰胺，喹诺酮，万古霉素以及对革兰氏阳性和革兰氏阴性菌和假单胞菌具有广泛的抗菌活性具有很强的抗菌活性 。 在式中，R1，R2，R4，R5，X和Y在说明书中定义。