公开(公告)号：KR101464280B1

公开(公告)日：2014-11-24

申请号：KR1020120092441

申请日：2012-08-23

Applicant: 한국과학기술연구원

Inventor： 노은주 ,  이창준 ,  오수진 ,  황석진 ,  정종훈

IPC: C07D333/20 ,  C07D333/40 ,  A61K31/381 ,  A61P19/10

Abstract: 본 발명은 칼슘의존성 클로라이드 채널 차단제로서 작용하는 신규 화합물에 관한 것이다.

公开(公告)号：KR1020140025902A

公开(公告)日：2014-03-05

申请号：KR1020120092441

申请日：2012-08-23

Applicant: 한국과학기술연구원

Inventor： 노은주 ,  이창준 ,  오수진 ,  황석진 ,  정종훈

IPC: C07D333/20 ,  C07D333/40 ,  A61K31/381 ,  A61P19/10

Abstract: The present invention relates to a novel compound which is useful for blocking a calcium-dependent chloride channel and, more specifically, to a chemical compound or a pharmaceutically approved salt compound thereof, which is presented in chemical formula 1. In chemical formula 1, X stands for -S- or -C=C-; R1 stands for a hydrogen atom, a halogen atom, a nitro group, a C1-C6 alkyl group, or a C1-C6 haloalkyl group; R2 stands for a substituted or non-substituted phenyl group or a substituted or non-substituted naphthyl group, substituted by one to three groups chosen among halo, nitro, C1-C6 alkyl, C1-C6 alkoxy, and C1-C6 haloalkyl groups. However, when the X stands for -C=C-, a compound whose R2 is substituted or not substituted phenyl group is excluded.

Abstract translation: 本发明涉及一种可用于阻断钙依赖性氯离子通道的新化合物，更具体地说，涉及化学式1中所示化学化合物或其药学上认可的盐化合物。在化学式1中，X 代表-S-或-C = C-; R1代表氢原子，卤素原子，硝基，C1-C6烷基或C1-C6卤代烷基; R2代表取代或未取代的苯基或被一至三个选自卤素，硝基，C 1 -C 6烷基，C 1 -C 6烷氧基和C 1 -C 6卤代烷基的基团取代或未取代的萘基。 然而，当X代表-C = C-时，不包括其R2为取代或未取代的苯基的化合物。