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    1,2-디[2-메톡시-4-(2-카르복실비닐)]페녹시에탄 화합물을유효성분으로 함유하는 파킨슨병 예방 및 치료용 약학적조성물
    2.
    发明公开
    1,2-디[2-메톡시-4-(2-카르복실비닐)]페녹시에탄 화합물을유효성분으로 함유하는 파킨슨병 예방 및 치료용 약학적조성물 无效
    用于预防和治疗含有1,2-二[2-甲氧基-4-（2-羧基乙基）]苯氧基乙烷作为活性成分的帕金森病的药物组合物

    公开(公告)号：KR1020080035294A

    公开(公告)日：2008-04-23

    申请号：KR1020060101803

    申请日：2006-10-19

    Applicant: 한국과학기술연구원

    Inventor： 신계정 ,  김동진 ,  황온유

    IPC: A61K31/194 ,  A61P25/28

    CPC classification number: A61K31/194

    Abstract: A pharmaceutical composition comprising 1,2-di[2-methoxy-4-(2-carboxylvinyl)]phenoxyethane is provided to protect dopaminergic nerve cells from toxic materials including 1-methyl4-phenylpyridinum(MMP^+), tetrahydrobiopterin(BH4), hydrogen peroxide(H2O2), 1-methyl-4-phenyl-1,2,4,6-tetrahydropyridine, so that the composition is useful for prevention and treatment of Parkinson's disease. A pharmaceutical composition for prevention and treatment of Parkinson' s disease comprises 1,2-di[2-methoxy-4-(2-carboxylvinyl)]phenoxyethane represented by the formula(1) which is prepared by reacting hydroxybenzaldehyde represented by the formula(2) with ethyleneglycol detosylate represented by the formula(3) in the presence of base to prepare benzaldehyde dimmer represented by the formula(4); and reacting the benzaldehyde dimmer represented by the formula(4) with malonic acid at 80-100 deg. C for 2-6 hours, or its pharmaceutically acceptable salts.

    Abstract translation: 提供了包含1,2-二[2-甲氧基-4-（2-羧基乙烯基）]苯氧基乙烷的药物组合物，以保护多巴胺能神经细胞免受毒性物质的影响，包括1-甲基-4-苯基吡啶（MMP ^ +），四氢生物喋呤（BH4） 过氧化氢（H 2 O 2），1-甲基-4-苯基-1,2,4,6-四氢吡啶，使得该组合物可用于预防和治疗帕金森病。 用于预防和治疗帕金森病的药物组合物包含由式（1）表示的1,2-二[2-甲氧基-4-（2-羧基乙烯基）]苯氧基乙烷，其通过使由式（1）表示的羟基苯甲醛 2）与由式（3）表示的乙二醇脱甲苯磺酸在碱存在下反应制备式（4）所示的苯甲醛二聚体; 并使由式（4）表示的苯甲醛二聚体与丙烯酸在80-100℃反应。 2-6小时，或其药学上可接受的盐。

    산화질소 생성 억제용 피라졸로피리미딘 유도체 화합물
    6.
    发明公开
    산화질소 생성 억제용 피라졸로피리미딘 유도체 화합물 有权
    吡唑并嘧啶衍生物，抑制生产氮氧化物的组合物和药物组合物，用于预防和治疗包括其的疾病

    公开(公告)号：KR1020130112248A

    公开(公告)日：2013-10-14

    申请号：KR1020120034483

    申请日：2012-04-03

    Applicant: 한국과학기술연구원 ,  울산대학교 산학협력단

    Inventor： 정찬성 ,  김동진 ,  박기덕 ,  김윤경 ,  표정인 ,  김현태 ,  황온유 ,  아쉬라 ,  송치만 ,  김영수

    IPC: C07D487/04 ,  A61K31/519 ,  A61P25/00

    Abstract: PURPOSE: A composition containing a pyrazolopyrimidine derivative compound for suppressing NO generation and a pharmaceutical composition containing the pyrazolopyrimidine derivative compound for preventing and treating neurological disorders are provided to suppress NO generation in vivo and to treat neurological disorders caused by functional disturbance and apoptosis of neural cells. CONSTITUTION: A pyrazolopyrimidine derivative compound of chemical formulas I-VII or a pharmaceutically acceptable salt thereof is provided. A pharmaceutical composition for suppressing NO generation contains a pharmaceutically acceptable carrier or diluent and the compounds as active ingredients. A composition for treating neurological disorders contains the pharmaceutically acceptable carrier or diluent and the compounds as active ingredients. The neurological diseases are selected among Parkinson's disease, Alzheimer's disease, Huntington's disease, amylotrophic lateral sclerosis, epilepsia, depression, pain, anxiety, and neurodegenerative diseases.

    Abstract translation: 目的：提供含有用于抑制NO产生的吡唑并嘧啶衍生物化合物和含有吡唑并嘧啶衍生物化合物用于预防和治疗神经障碍的药物组合物，用于抑制体内NO产生并治疗由神经细胞的功能紊乱和细胞凋亡引起的神经障碍 。 构成：提供化学式I-VII的吡唑并嘧啶衍生物化合物或其药学上可接受的盐。 用于抑制NO生成的药物组合物含有药学上可接受的载体或稀释剂，作为活性成分的化合物。 用于治疗神经障碍的组合物含有药学上可接受的载体或稀释剂，并且所述化合物作为活性成分。 神经系统疾病选自帕金森病，阿尔茨海默病，亨廷顿病，肌营养性侧索硬化，癫痫，抑郁，疼痛，焦虑和神经变性疾病。

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