公开(公告)号：KR1020120038034A

公开(公告)日：2012-04-23

申请号：KR1020100097911

申请日：2010-10-07

Applicant: 한국과학기술연구원 ,  서울대학교산학협력단

Inventor： 배애님 ,  남길수 ,  또라트,다나지아튜트라오 ,  추현아 ,  조용서

IPC: C07D405/12 ,  A61K31/517 ,  A61P35/00

Abstract: PURPOSE: A 2,4-diaminoquinazoline compound with anticancer activity is provided to be used as an anticancer agent. CONSTITUTION: A 2,4-diaminoquinazoline compound is denoted by chemical formula 1. A pharmaceutical composition for anticancer contains 2,4-diaminoquinazoline compound of chemical formula 1. A method for preparing the compound of chemical formula 1 comprises: a step of binding 2-chloro-N-(furnylmethyl)quinazoliine-4-amine compounds of chemical formula 2 with an amine compound of chemical formula 3.

Abstract translation: 目的：提供具有抗癌活性的2,4-二氨基喹唑啉化合物作为抗癌剂。 构成：2,4-二氨基喹唑啉化合物由化学式1表示。抗癌用药物组合物含有化学式1的2,4-二氨基喹唑啉化合物。化学式1化合物的制备方法包括：将2 - 氯-N-（苄基甲基）喹唑啉-4-胺化合物与化学式3的胺化合物。

公开(公告)号：KR101263263B1

公开(公告)日：2013-05-10

申请号：KR1020100097911

申请日：2010-10-07

Applicant: 한국과학기술연구원 ,  서울대학교산학협력단

Inventor： 배애님 ,  남길수 ,  또라트,다나지아튜트라오 ,  추현아 ,  조용서

IPC: C07D405/12 ,  A61K31/517 ,  A61P35/00

Abstract: 본발명은항암활성을가지는 2,4-다이아미노퀴나졸린화합물및 약제학적으로허용가능한이의염, 이들화합물의제조방법, 그리고이들화합물이유효성분으로함유된약제조성물에관한것이다.