公开(公告)号：KR1020140107153A

公开(公告)日：2014-09-04

申请号：KR1020140093049

申请日：2014-07-23

Applicant: 한국과학기술원

Inventor： 홍승우 ,  박황서 ,  홍승희 ,  김진희

IPC: A61K31/4184 ,  A61P9/00 ,  A61P29/00 ,  A61P37/00

CPC classification number: A61K31/4184 ,  A61K31/4188 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/496 ,  Y10S514/885 ,  Y10S514/886

Abstract: The present invention relates to a benzimidazole, benzothiazole, and imidazopyridine derivative compound represented by chemical formula 1, an Abl kinase inhibiting composition comprising the same, and a pharmaceutical composition for preventing and treating abnormal cell growth diseases. The benzimidazole, benzothiazole, and imidazopyridine derivative compound and a pharmaceutically acceptable salt thereof, according to the present invention, can be used for treating, as an inhibitor of Abl kinase, diseases resulting from abnormal cell growth, function, or behavior such as cancer, immune disorders, cardiovascular disease, viral infection, inflammatory diseases, endocrine disorders, and neurological disorders.

Abstract translation: 本发明涉及由化学式1表示的苯并咪唑，苯并噻唑和咪唑并吡啶衍生物化合物，含有该化合物的Abl激酶抑制组合物和用于预防和治疗异常细胞生长疾病的药物组合物。 根据本发明的苯并咪唑，苯并噻唑和咪唑并吡啶衍生物化合物及其药学上可接受的盐可用于治疗由异常细胞生长，功能或行为导致的疾病，作为Abl激酶的抑制剂，例如癌症， 免疫疾病，心血管疾病，病毒感染，炎性疾病，内分泌障碍和神经障碍。

公开(公告)号：KR101746199B1

公开(公告)日：2017-06-13

申请号：KR1020160084370

申请日：2016-07-04

Applicant: 기초과학연구원 ,  한국과학기술원

Inventor： 홍승우 ,  김진희 ,  박황서 ,  신용제

IPC: C07D261/20 ,  C07D209/08 ,  C07D471/04 ,  C07D413/12 ,  C07D403/12 ,  C07D403/14 ,  A61K31/42 ,  A61K31/404 ,  A61K31/437

CPC classification number: C07D261/20 ,  A61K31/404 ,  A61K31/42 ,  A61K31/437 ,  C07D209/08 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D471/04

Abstract: 본발명은 GSK3β저해활성을갖는신규한화학식 1의화합물또는이의약학적으로허용가능한염을제공한다. [화학식 1]상기화학식 1에서, X는탄소(C) 또는질소(N)이고; Y는탄소(C) 또는산소(O)이며; R은수소, 아릴, -CO-아릴또는헤테로아릴이며, 이때상기아릴또는헤테로아릴은치환되지않거나또는치환될수 있고; R는 -CO-NH-(CH)-CO-NH-, -CO-O-(CH)-, -CH=CH-(CH)-CO-NH- 또는 -(CH)-CO-NH-이며, 이때 n은 1 내지 3의정수이고 m은 0 내지 3의정수이며; R는 C알킬, -(CH)-아릴, -(CH)-헤테로아릴또는 -(CH)-헤테로사이클릴이고, 이때상기아릴, 헤테로아릴또는헤테로사이클릴은치환되지않거나또는치환될수 있다. 상기화학식 1의화합물은 GSK3β와연관된질환, 즉증식성질환, 신경변성또는신경성질환, 염증성자가면역질환, 심혈관질환, 내분비질환, 및바이러스감염질환을예방또는치료하는데유용하다.

Abstract translation: 本发明提供了具有GSK3β抑制活性的新型式（I）化合物或其药学上可接受的盐。 [化学式1]在式1中，X是碳（C）或氮（N）; Y是碳（C）或氧（O）; R为氢，芳基，-CO-芳基或杂芳基，其中所述芳基或杂芳基可以未被取代或被取代; R是-CO-NH-（CH）-CO-NH-，-CO-O-（CH） - ， - CH = CH- 其中n是1至3的数，m是0至3; 可以是一个杂环基，其中所述芳基，杂芳基或杂环基任选取代或取代的 - R 1是C烷基， - （CH） - 芳基， - （CH） - ，或杂芳基 - （CH）。 式（I）的化合物可用于预防或治疗与相关的疾病，或增殖性疾病，神经变性或神经学病症，炎症性自身免疫疾病，心血管疾病，内分泌失调，和病毒感染和GSK3β有用。

公开(公告)号：KR101546743B1

公开(公告)日：2015-08-24

申请号：KR1020120004827

申请日：2012-01-16

Applicant: 한국과학기술원

Inventor： 홍승우 ,  박황서 ,  홍승희 ,  김진희

IPC: C07D235/10 ,  C07D277/82 ,  A61K31/4184 ,  A61P35/00

Abstract: 본발명은하기 [화학식 1]로표시되는벤즈이미다졸, 벤조싸이아졸및 이미다조피리딘유도체화합물, 이를포함하는 Abl 키나제저해제조성물및 이상세포성장질환의예방및 치료용약학조성물에관한것으로서, 본발명에따른벤즈이미다졸, 벤조싸이아졸또는이미다조피디린유도체화합물및 이의약학적수용가능한염은 Abl 키나제에대한저해제로서비정상적세포성장, 기능또는거동으로부터야기되는질환, 특히, 암, 면역질환, 심혈관질환, 바이러스감염질환, 염증성질환, 내분비질환및 신경성질환을치료하는데사용할수 있다. [화학식 1]

公开(公告)号：KR1020130084083A

公开(公告)日：2013-07-24

申请号：KR1020120004827

申请日：2012-01-16

Applicant: 한국과학기술원

Inventor： 홍승우 ,  박황서 ,  홍승희 ,  김진희

IPC: C07D235/10 ,  C07D277/82 ,  A61K31/4184 ,  A61P35/00

Abstract: PURPOSE: An indole derivative compound, and an Abl kinase inhibitor composition and a pharmaceutical composition for preventing and treating abnormal cell growth diseases containing the same are provided to treat diseases caused by abnormal cell growth, function, or behavior, especially cancer, immune diseases, cardiovascular diseases, viral infectious diseases, inflammatory diseases, endocrine diseases, and neurological diseases. CONSTITUTION: An indole derivative of chemical formula 1 or a pharmaceutically acceptable salt is provided. A pharmaceutical composition for suppressing wild type Abl kinase and mutant type Abl (T315I) kinase contains the compound as an active ingredient and a pharmaceutically acceptable carrier or diluents. A pharmaceutical composition for treating proliferative diseases, immune diseases, cardiovascular diseases, neurological diseases, inflammatory diseases, endocrine diseases, or viral infectious diseases contains the compound as an active ingredient and a pharmaceutically acceptable carrier or diluents.

Abstract translation: 目的：提供吲哚衍生物化合物和Abl激酶抑制剂组合物和用于预防和治疗含有其的异常细胞生长疾病的药物组合物，以治疗由异常细胞生长，功能或行为引起的疾病，特别是癌症，免疫疾病， 心血管疾病，病毒感染性疾病，炎性疾病，内分泌疾病和神经疾病。 构成：提供化学式1的吲哚衍生物或其药学上可接受的盐。 用于抑制野生型Abl激酶和突变型Abl（T315I）激酶的药物组合物含有作为活性成分的化合物和药学上可接受的载体或稀释剂。 用于治疗增殖性疾病，免疫疾病，心血管疾病，神经疾病，炎性疾病，内分泌疾病或病毒感染性疾病的药物组合物含有作为活性成分的化合物和药学上可接受的载体或稀释剂。