公开(公告)号：KR1020000066159A

公开(公告)日：2000-11-15

申请号：KR1019990013041

申请日：1999-04-13

Applicant: 한국과학기술원

Inventor： 장호남 ,  장용근 ,  권선훈 ,  이우기 ,  이평천 ,  유익근 ,  임성진

IPC: C12M1/00

CPC classification number: C12P7/46 ,  C12M23/58 ,  C12M29/18 ,  C12M41/26 ,  C12P7/40 ,  C12P7/42 ,  C12P7/48

Abstract: PURPOSE: A process for efficiently producing organic acid by continuously fermenting organic acid fermentation microorganisms in a cell recirculation multistage continuous fermenter and recovering organic acid from the culture solution is provided which reduces equipment and production costs and promotes productivity. CONSTITUTION: An organic acid-fermentable microorganism is fermented in a cell recirculation multistage continuous fermenter connected in series a fermenter comprising a fermentation tank, a temperature controller, an agitator and a pH controller, a circulation pump for circulating fermentation mediums from the fermenter to the outside and a cell separator for separating the fermentation mediums and recirculating. The process can be applied to a fermentation process for producing lactic acid, acetic acid, formic acid, citric acid, malic acid, maleic acid, fumaric acid or succinic acid that shows productivity reduction by final products.

Abstract translation: 目的：提供一种通过在细胞再循环多级连续发酵罐中连续发酵有机酸发酵微生物并从培养液中回收有机酸有效生产有机酸的方法，其降低了设备和生产成本并提高了生产率。 构成：将有机酸可发酵微生物在连续发酵的细胞再循环多级连续发酵罐中发酵，发酵罐包括发酵罐，温度控制器，搅拌器和pH控制器，循环泵，用于将发酵培养基从发酵罐循环到 外部和用于分离发酵培养基并再循环的细胞分离器。 该方法可用于产生乳酸，乙酸，甲酸，柠檬酸，苹果酸，马来酸，富马酸或琥珀酸的发酵方法，其显示最终产物的生产率降低。

公开(公告)号：KR100329019B1

公开(公告)日：2002-03-18

申请号：KR1019990013041

申请日：1999-04-13

Applicant: 한국과학기술원

Inventor： 장호남 ,  장용근 ,  권선훈 ,  이우기 ,  이평천 ,  유익근 ,  임성진

IPC: C12M1/00

CPC classification number: C12P7/46 ,  C12M23/58 ,  C12M29/18 ,  C12M41/26 ,  C12P7/40 ,  C12P7/42 ,  C12P7/48

Abstract: 본발명은유기산(organic acid)의고효율생산방법에관한것이다. 본발명의유기산의고효율생산방법은세포재순환장치를포함하는연속발효기를직렬로연결한세포재순환다단연속발효기를이용하여, 유기산발효미생물을연속발효시켜유기산을생산하는방법이다. 본발명의유기산의고효율생산방법에의하면, 90g/L 이상의고농도유기산용액을 50g/L/h의생산성인고효율로생산할수 있다. 이러한결과는종래의방법들과비교해볼 때, 생산성을크게향상시킨것이며, 아울러생산되는유기산의농도가높다는것에중요한의미가있는바, 유기산의대량생산을위한공장건설비및 생산비용을획기적으로줄일수 있다. 또한, 본발명은최종산물에의해생산성저해현상이나타나는젖산, 초산, 개미산, 구연산, 사과산, 말레산, 푸마레산또는호박산등의유기산을생산하기위한발효공정에공통적으로적용될수 있다.