公开(公告)号：KR1020030077363A

公开(公告)日：2003-10-01

申请号：KR1020020016445

申请日：2002-03-26

Applicant: 한국과학기술원

Inventor： 김선창 ,  박인엽 ,  조주현

IPC: C07K7/08

CPC classification number: C07K14/43527 ,  A61K38/00 ,  C07K7/08 ,  C07K14/001 ,  C07K14/4723 ,  Y02A50/481

Abstract: PURPOSE: Provided are antimicrobial peptide derivatives which involve powerful antimicrobial activity with respect to gram positive bacillus, gram negative bacillus and fungus. They powerfully inhibit microbial expression at the wound portion while not exhibiting any hemolysis, and are used as antimicrobial agent for the wound treatment facilitation, trauma treatment, mouthwash, and eyewash. CONSTITUTION: The antimicrobial peptide comprises an amino acid sequence expressed by formula 1(N-terminal-X1X2X3X4X5X6X7X8X9X10X11X12X13X14X15-C-terminal), wherein X1 is vacant or a basic amino acid, X2 is two hydrophobic amino acids identical with or different from each other, and X3 is a basic amino acid. Furthermore, in the formula 1, X4 is glutamine or asparagine, X5 is phenylalanine or tryptophan, X6 is proline, X7 is isoleucine or valine, X8 is glycine, X9 is a basic amino acid, X10, X12 and X14 are two hydrophobic amino acids identical with or different from each other, respectively, X11 and X13 are basic amino acids identical with or different from each other, respectively, and X15 is vacant or a basic amino acid.

Abstract translation: 目的：提供抗菌肽衍生物，其涉及革兰氏阳性杆菌，革兰氏阴性杆菌和真菌具有强大的抗微生物活性。 它们强力地抑制伤口部分的微生物表达，而不显示任何溶血作用，并且用作伤口治疗促进，创伤治疗，漱口水和洗眼剂的抗微生物剂。 构成：抗微生物肽包含由式1表示的氨基酸序列（N-末端-X 1 X 2 X 3 X 4 X 5 X 6 X 7 X 8 X 9 X 10 X 11 X 12 X 13 X 14 X 15 C-末端），其中X 1为空位或碱性氨基酸，X 2为彼此相同或不同的2个疏水性氨基酸， X3是碱性氨基酸。 此外，在式1中，X4为谷氨酰胺或天冬酰胺，X5为苯丙氨酸或色氨酸，X6为脯氨酸，X7为异亮氨酸或缬氨酸，X8为甘氨酸，X9为碱性氨基酸，X10为X12，X14为两个疏水性氨基酸 分别相同或不同，X 11和X 13分别是彼此相同或不同的碱性氨基酸，X15为空位或碱性氨基酸。

公开(公告)号：KR100441402B1

公开(公告)日：2004-07-23

申请号：KR1020020016445

申请日：2002-03-26

Applicant: 한국과학기술원

Inventor： 김선창 ,  박인엽 ,  조주현

IPC: C07K7/08

CPC classification number: C07K14/43527 ,  A61K38/00 ,  C07K7/08 ,  C07K14/001 ,  C07K14/4723 ,  Y02A50/481

Abstract: Disclosed is a novel antimicrobial peptide having excellent antimicrobial activities, its analogs and an antimicrobial composition comprising them. The antimicrobial peptide alternatively comprises basic amino acid residues and hydrophobic amino acid residues, and is able to penetrate into microbial cells and act against a wide variety of microorganisms.

Abstract translation: 公开了具有优异抗微生物活性的新型抗微生物肽，其类似物和包含它们的抗微生物组合物。 抗微生物肽可选地包含碱性氨基酸残基和疏水性氨基酸残基，并且能够穿透微生物细胞并对抗各种各样的微生物。