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公开(公告)号：KR102245325B1
公开(公告)日：2021-04-28
申请号：KR1020190095137
申请日：2019-08-05
Applicant: 한국생명공학연구원 , 대한민국(농림축산식품부 농림축산검역본부장)
IPC: C07K16/10 , A61P31/14 , G01N33/569
Abstract: 본발명은구제역바이러스의혈청형 7종중 O형에특이적으로결합또는모든혈청형에광범위하게결합가능한소 유래단일클론항체및 이를포함하는구제역바이러스진단용키트, 이를이용한구제역의진단방법, 구제역의예방또는치료방법에관한것이다. 구체적으로, 상기단일클론항체는구제역바이러스에특이적으로결합하는단일클론항체는구제역바이러스의항원과특이적으로결합하여구제역바이러스의검출용항체로사용될수 있으며, 구제역바이러스에대한중화능이우수하고소에서유래되어소의면역거부반응발생에대한우려가없으므로긴급시구제역예방용및 치료용백신으로사용될수 있다.
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公开(公告)号：KR20210016850A
公开(公告)日：2021-02-17
申请号：KR20190095137
申请日：2019-08-05
Applicant: 한국생명공학연구원 , 대한민국(농림축산식품부 농림축산검역본부장)
IPC: C07K16/10 , A61P31/14 , G01N33/569
Abstract: 본발명은구제역바이러스의혈청형 7종중 O형에특이적으로결합또는모든혈청형에광범위하게결합가능한소 유래단일클론항체및 이를포함하는구제역바이러스진단용키트, 이를이용한구제역의진단방법, 구제역의예방또는치료방법에관한것이다. 구체적으로, 상기단일클론항체는구제역바이러스에특이적으로결합하는단일클론항체는구제역바이러스의항원과특이적으로결합하여구제역바이러스의검출용항체로사용될수 있으며, 구제역바이러스에대한중화능이우수하고소에서유래되어소의면역거부반응발생에대한우려가없으므로긴급시구제역예방용및 치료용백신으로사용될수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020070099214A
公开(公告)日：2007-10-09
申请号：KR1020060030309
申请日：2006-04-03
Applicant: 한국생명공학연구원
CPC classification number: C07K16/1072 , C12N15/63 , G01N33/5761
Abstract: A humanized antibody against a surface antigen pre-S1 of Hepatitis B virus(HBV) is provided to secure the antigen binding capacity similar to that of a mouse monoclonal antibody and have significantly decreased immunity inducing capacity in human due to having more humanized amino acid residue, thereby being usefully used for preventing and treating HBV infection. A humanized antibody against a surface antigen pre-S1 of HBV is characterized in that an amino acid sequence of a heavy chain region is described as SEQ ID : NO. 10 or an amino acid sequence of a light chain region is described as SEQ ID : NO. 20. An expression vector comprises a gene coding an amino acid sequence described as SEQ ID : NO. 19, a gene coding an amino acid sequence described as SEQ ID : NO. 20, and a chimera antibody coding an invariable region of a human IgG antibody. A composition for preventing and treating Hepatitis B comprises a chimera antibody expressed by the expression vector. A kit for detecting HBV comprises the antibody.
Abstract translation: 提供针对乙型肝炎病毒（HBV）前S1的抗原表面抗原的人源化抗体以确保与小鼠单克隆抗体相似的抗原结合能力，并且由于具有更多的人源化氨基酸残基而在人体中具有显着降低的免疫诱导能力 从而有效地用于预防和治疗HBV感染。 针对HBV表面抗原pre-S1的人源化抗体的特征在于重链区的氨基酸序列描述为SEQ ID NO： 10或轻链区域的氨基酸序列描述为SEQ ID NO： 表达载体包含编码SEQ ID NO：1所示的氨基酸序列的基因。 19，编码如SEQ ID NO：1所示的氨基酸序列的基因。 20和编码人IgG抗体的不变区的嵌合体抗体。 用于预防和治疗乙型肝炎的组合物包含由表达载体表达的嵌合体抗体。 用于检测HBV的试剂盒包含抗体。
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5.发明公开
公开(公告)号：KR1020110133278A
公开(公告)日：2011-12-12
申请号：KR1020100052917
申请日：2010-06-04
Applicant: 한국생명공학연구원
IPC: C07K16/18 , C12N15/13 , C12N15/63 , G01N33/574
Abstract: PURPOSE: An antibody which specifically binds to TIMP-1 with N-linked beta(1,6) branch or antigen-binding fragment thereof are provided to obtain information of metastasis or progression of cancer. CONSTITUTION: An antibody or epitope fragment thereof specifically binds to TIMP-1(tissue inhibitor of metalloproteinase-1) with N-linked beta(1,6) branch. The antibody and antigen-binding fragment thereof also specifically binds to TIMP-1 further comprising sialic acid at the end of N-linked beta(1,6) branch sugar chain. A method for preparing the antibody or antigen-binding fragment thereof comprises: a step of culturing host cells which is transformed by a recombinant vector; and a step of expressing the antibody and antigen-binding fragment thereof in the host cells. A composition for diagnosing cancer metastasis or progression contains the antibody or antigen-binding fragment thereof as an active ingredient.
Abstract translation: 目的：提供与N-连接的β（1,6）支链或其抗原结合片段特异性结合TIMP-1的抗体，以获得癌症转移或进展的信息。 构成：抗体或其表位片段与N-连接的β（1,6）分支特异性结合TIMP-1（金属蛋白酶-1的组织抑制剂）。 抗体及其抗原结合片段还特异性结合在N-连接的β（1,6）分支糖链末端进一步包含唾液酸的TIMP-1。 制备抗体或其抗原结合片段的方法包括：培养由重组载体转化的宿主细胞的步骤; 以及在宿主细胞中表达抗体及其抗原结合片段的步骤。 用于诊断癌症转移或进展的组合物含有作为活性成分的抗体或其抗原结合片段。
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6.发明授权
公开(公告)号：KR101214262B1
公开(公告)日：2012-12-21
申请号：KR1020100052917
申请日：2010-06-04
Applicant: 한국생명공학연구원
IPC: C07K16/18 , C12N15/13 , C12N15/63 , G01N33/574
Abstract: 본발명은 GnT-V에의해도입된비정상적당쇄인 N-연결 &bgr;(1,6) 가지를갖는 TIMP-1에특이적으로결합하는항체또는이의항원결합단편, 이를코딩하는핵산분자, 상기핵산분자를포함하는재조합벡터및 숙주세포에관한것이다. 또한, 본발명은상기항체를유효성분으로서포함하는암의전이또는진행진단용조성물에관한것이다. 본발명의항체는 GnT-V에의해 TIMP-1 단백질에도입된비정상적당쇄로부터유도되는구조적변화를구별할수 있다. 본발명의항체를이용하여비정상적당쇄가도입된 TIMP-1 단백질을검출함으로써암의전이또는진행에관한정보를용이하게얻을수 있다.
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公开(公告)号：KR101302218B1
公开(公告)日：2013-08-30
申请号：KR1020060030309
申请日：2006-04-03
Applicant: 한국생명공학연구원
Abstract: 본 발명은 B형 간염 바이러스의 pre-S1 단백질에 특이적으로 결합하는 항체, 상기 항체의 중쇄(Heavy chain) 및 경쇄(Light chain) 가변 영역 유전자, 이를 포함하는 발현 벡터, 발현 벡터에 의해 형질 전환된 형질 전환체 및 B형 간염 바이러스의 검출 키트에 관한 것이다.
키메라 항체, B형 간염 바이러스
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