公开(公告)号：KR100837856B1

公开(公告)日：2008-06-13

申请号：KR1020060127970

申请日：2006-12-14

Applicant: 한국식품연구원

Inventor： 차성관 ,  이명기 ,  장진희

IPC: C12N1/20

Abstract: A novel lactic acid bacteria isolated during a fermentation process of chopped radishes picked salt water is provided to show excellent digestive fluid resistance and have the anti-cancer activity. A novel Lactobacillus sp. DK250340 strain isolated from chopped radishes picked salt water is deposited as a deposition no. KCTC 11034BP and is characterized in that it shows excellent tolerance to digestive fluids such as acid resistance and bile acid resistance and anti-cancer activity such as cytotoxicity and QR activity.

Abstract translation: 在切碎的萝卜发酵过程中分离的新型乳酸菌提取盐水以显示出优异的消化液阻力并具有抗癌活性。 一种新型的乳杆菌属 DK250340菌株从切碎的萝卜中分离出来的盐水沉积成沉积物。 KCTC 11034BP，其特征在于其对消化液具有优异的耐受性，例如耐酸性和耐胆汁酸性以及抗癌活性如细胞毒性和QR活性。

公开(公告)号：KR100827318B1

公开(公告)日：2008-05-07

申请号：KR1020060060969

申请日：2006-06-30

Applicant: 한국식품연구원

Inventor： 차성관 ,  최신양 ,  안병학 ,  한찬규 ,  장진희

IPC: C12N1/20

Abstract: 본 발명은 내산성, 내담즙성이 강하고 항암 활성이 있는 젖산균 및 이를 함유하는 발효유에 관한 것으로, 더욱 상세하게는 내산성, 내담즙성이 강하고 항암 활성이 있는 젖산균
Lactobacillus acidophilus KFRI 342 (KCTC 10827BP) 및, 상기 균주를 함유하는 항암활성이 있는 기능성 발효유에 관한 것이다.
본 발명의
Lactobacillus acidophilus KFRI 342 젖산균은 내산성, 내담즙성이 강하고 우수한 항암 효과를 나타낸다. 또한,
Lactobacillus acidophilus KFRI 342 젖산균을 함유한 발효유는 암세포주에 대하여 세포독성을 나타내므로, 암 예방 및 치료에 대한 보조 식품으로써 우수한 기능성 발효유를 제공할 수 있다.
젖산균, 내담즙성, 발효유

公开(公告)号：KR1020080002263A

公开(公告)日：2008-01-04

申请号：KR1020060060969

申请日：2006-06-30

Applicant: 한국식품연구원

Inventor： 차성관 ,  최신양 ,  안병학 ,  한찬규 ,  장진희

IPC: C12N1/20

Abstract: A lactic acid bacterium having strong acid and bile tolerance is provided to inhibit growth of cancer cells, so that the microorganism is useful for producing the functional food including the fermented milk capable of preventing and treating cancer. A lactic acid bacterium having strong acid and bile tolerance, Lactobacillus acidophilus KFRI 342(KCTC 10827BP), is isolated from kimchi and increases activity of quinone reductase associated with detoxication of carcinogens. The fermented milk by using Lactobacillus acidophilus KFRI 342(KCTC 10827BP) shows cytotoxicity to cancer cell, especially large intestine cancer cell line SNU C4.

Abstract translation: 提供具有强酸和胆汁耐受性的乳酸菌以抑制癌细胞的生长，使得微生物可用于生产包括能够预防和治疗癌症的发酵乳的功能性食品。 从泡菜中分离出具有强酸和胆汁耐受性的嗜酸乳杆菌KFRI 342（KCTC 10827BP）的乳酸菌，并增加与致癌物质解毒相关的醌还原酶的活性。 使用嗜酸乳杆菌KFRI 342（KCTC 10827BP）的发酵乳显示出对癌细胞，特别是大肠癌细胞系SNU C4的细胞毒性。