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公开(公告)号：KR1020110119513A
公开(公告)日：2011-11-02
申请号：KR1020100129333
申请日：2010-12-16
Applicant: 한국전자통신연구원
CPC classification number: G01N33/6896 , G01N33/54373 , G01N2446/00 , G01N2800/2821
Abstract: PURPOSE: A method for early diagnosing Alzheimer's disease using a phototransistor is provided to enable early diagnosis of the disease and to quantitate cells or beta-amyloid proteins. CONSTITUTION: A method for early diagnosing Alzheimer's disease using a phototransistor comprises: a step of placing the phototransistor for sensing photocurrent difference according to the amount of incident light and a step of sensing photocurrent different according to cells fixed on the surface of a channel layer. The phototransistor comprises the channel layer. The cells have a protein biomarker causing Alzheimer's disease. The protein biomarker is labeled with magnetic particles(200) which are conjugated with multi-proteins. The protein biomarker is beta-amyloid protein(240).
Abstract translation: 目的：提供一种使用光电晶体管早期诊断阿尔茨海默氏病的方法，以便早期诊断疾病并定量细胞或β-淀粉样蛋白。 构成：使用光电晶体管来早期诊断阿尔茨海默病的方法包括：根据入射光量放置用于感测光电流差的光电晶体管的步骤，以及根据固定在沟道层表面上的电池感测不同光电流的步骤。 光电晶体管包括沟道层。 细胞具有引起阿尔茨海默氏病的蛋白质生物标志物。 蛋白质生物标志物用与多蛋白结合的磁性颗粒（200）标记。 蛋白质生物标志物是β-淀粉样蛋白（240）。
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公开(公告)号：KR1020140032255A
公开(公告)日：2014-03-14
申请号：KR1020120098931
申请日：2012-09-06
Applicant: 한국전자통신연구원
Abstract: Disclosed is a method for manufacturing a photoelectric conversion device. The method includes a step of forming a gate insulating layer on a gate electrode layer, a step of forming an active layer on the gate insulating layer, a step of forming a source electrode on the active layer and a drain electrode separated from the source electrode. Here, the active layer can be formed by a spray method or a liquid phase deposition method.
Abstract translation: 公开了一种制造光电转换装置的方法。 该方法包括在栅电极层上形成栅极绝缘层的步骤，在栅极绝缘层上形成有源层的步骤，在有源层上形成源电极的步骤以及与源电极分离的漏电极 。 这里，活性层可以通过喷雾法或液相沉积法形成。
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公开(公告)号：KR1020140025978A
公开(公告)日：2014-03-05
申请号：KR1020120092787
申请日：2012-08-24
Applicant: 한국전자통신연구원
IPC: G01N33/533 , G01N21/64 , G01N27/02
CPC classification number: G01N21/6486 , G01N33/54326 , G01N33/582 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
Abstract: Provided is a method of diagnosing Alzheimer′s disease using saliva. The method of diagnosing Alzheimer′s disease includes preparing magnetic particles having primary capture antibodies specifically bonded with beta-amyloid adsorbed thereon, introducing saliva containing beta-amyloid into the magnetic particles to bond the beta-amyloid contained in the saliva with the primary capture antibodies, bonding secondary capture antibodies labeled with fluorescent substances to the magnetic particles bonded with the beta-amyloid to form a complex, disposing the complex in a channel region of a photo field effect transistor in which photoelectric current is changed according to an amount of incident light, and measuring photoelectric current changed by light excited from the complex to quantify a concentration of the beta-amyloid contained in the saliva. [Reference numerals] (S110) Prepare magnetic particles; (S120) Extract beta-amyloid contained in saliva using the magnetic particles; (S130) Prepare a magnetic particle-multi-protein complex; (S140) Dispose the complex in a sensing region of a photo field effect transistor; (S150) Measure photoelectric current of the photo field effect transistor
Abstract translation: 提供了一种使用唾液诊断阿尔茨海默病的方法。 诊断阿尔茨海默病的方法包括制备具有与其上吸附的β-淀粉样蛋白特异性结合的初级捕获抗体的磁性颗粒，将含有β-淀粉样蛋白的唾液引入磁性颗粒中以将含有唾液中的β-淀粉样蛋白与初级捕获抗体 将用荧光物质标记的二次捕获抗体结合到与β-淀粉样蛋白结合的磁性颗粒中以形成复合物，将该复合物设置在光电流根据入射光量变化的光电场效应晶体管的沟道区域中 并且测量由络合物激发的光改变的光电流，以量化唾液中包含的β-淀粉样蛋白的浓度。 （参考号）（S110）准备磁性粒子; （S120）使用磁性粒子提取唾液中含有的β-淀粉样蛋白; （S130）制备磁性粒子 - 多蛋白复合物; （S140）在光场效应晶体管的感测区域中配置复合物; （S150）测量光电场效应晶体管的光电流
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公开(公告)号：KR1020120083831A
公开(公告)日：2012-07-26
申请号：KR1020110093040
申请日：2011-09-15
Applicant: 한국전자통신연구원
IPC: G01N21/27 , G01N33/483 , A61B5/00
Abstract: PURPOSE: A device and a method for detecting bio materials using a photoelectric conversion element and a method for manufacturing the photoelectric conversion element are provided to detect bio materials by using a simple method instead of a gene analysis and enable to apply for inspections proving the effectiveness of various drugs for curing and monitoring all sorts of diseases. CONSTITUTION: A device(100) for detecting bio materials using a photoelectric conversion element comprises a combined member(120), an optical filter(135), and a photoelectric conversion element(130). The combined member emits lights of the energy lower than the energy of the incident lights with a fluorescent material when the lights are incident in the state that bio materials and the fluorescent material are combined. The optical filter filters the lights emitted from the combined member among the lights becoming incident. The photoelectric conversion element converts the lights penetrated through the optical filter into electric signals.
Abstract translation: 目的：提供使用光电转换元件检测生物材料的装置和方法以及用于制造光电转换元件的方法，通过使用简单的方法而不是基因分析来检测生物材料，并且能够申请检验证明有效性 各种药物用于治疗和监测各种疾病。 构成：用于使用光电转换元件检测生物材料的装置（100）包括组合构件（120），滤光器（135）和光电转换元件（130）。 当组合成员以生物材料和荧光材料组合的状态入射时，用荧光材料发射能量低于入射光能量的光。 光滤波器过滤从组合成员发出的灯变成事故。 光电转换元件将穿过滤光器的光转换为电信号。
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Patent Agency Ranking
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6.发明授权
公开(公告)号：KR101504783B1
公开(公告)日：2015-03-23
申请号：KR1020100096495
申请日：2010-10-04
Applicant: 한국전자통신연구원
IPC: G01N33/68
Abstract: 본 발명은 거대자기저항 센서를 이용한 알츠하이머병의 진단방법 및 알츠하이머병 진단용 자기비드-다중단백질 복합체에 관한 것이다. 본 발명에 따른 거대자기저항 센서를 이용하여 알츠하이머병의 진단방법은 기존의 형광물질이나 유전자 분석 대신 거대자기저항 센서를 이용하여 간단한 방법으로 알츠하이머병을 쉽게 진단할 수 있고, 알츠하이머병 진단용 바이오 센서로 대량생산이 가능하므로, 알츠하이머병의 모니터링과 치료에 유용하게 사용할 수 있다.
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公开(公告)号：KR1020140054645A
公开(公告)日：2014-05-09
申请号：KR1020120120379
申请日：2012-10-29
Applicant: 한국전자통신연구원
CPC classification number: A61B5/0066 , A61B5/4011 , A61B5/4088
Abstract: A diagnostic device for Alzheimer′s disease is provided. The diagnostic device comprises a bar type image probe which is inserted into the nose and one end of which is in contact with an olfactory epithelium tissue part to obtain signals about the condition of the olfactory epithelium tissue part; a transmission means which transmits the signals by being connected to the other end of the bar type image probe; and a signal processing unit which converts the signals transmitted by the transmission means into digital signals.
Abstract translation: 提供了阿尔茨海默病的诊断装置。 该诊断装置包括插入到鼻子中的棒状图像探针，其一端与嗅觉上皮组织部分接触以获得关于嗅觉上皮组织部分的状况的信号; 传送装置，其通过连接到条形图像探测器的另一端来发送信号; 以及信号处理单元，其将由发送装置发送的信号转换为数字信号。
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公开(公告)号：KR1020130140528A
公开(公告)日：2013-12-24
申请号：KR1020120127613
申请日：2012-11-12
Applicant: 한국전자통신연구원
IPC: G01N33/68 , G01N33/533 , G01N21/64
Abstract: Provided is a method for diagnosing Alzheimer's disease using a decomposed biomaterial. The method comprises: preparing magnetic particles on which primary capture antibodies specifically bound to beta-amyloid are adsorbed; decomposing a biomaterial including beta-amyloid to bind the beta-amyloid present in the biomaterial to the primary capture antibodies; binding secondary capture antibodies labeled with a fluorescent material to the magnetic particles bound to the beta-amyloid to form a complex; disposing the complex in a channel region of a photo field effect transistor in which photocurrent is changed according to the amount of incident light; and measuring the photocurrent changed by light excited from the complex to quantify the concentration of the beta-amyloid present in the biomaterial. [Reference numerals] (S110) Prepare magnetic particles;(S120) Decompose biomaterial containing beta-amyloid protein;(S130) Forming a complex of the magnetic particles and multiple proteins;(S140) Disposing the complex in a sensing region of a photo field effect transistor;(S150) Measuring the photocurrent of the photo field effect transistor
Abstract translation: 提供了使用分解生物材料诊断阿尔茨海默氏病的方法。 该方法包括：制备其上吸附了特异性结合β-淀粉样蛋白的初级捕获抗体的磁性颗粒; 分解生物材料，包括β-淀粉样蛋白，将生物材料中存在的β-淀粉样蛋白结合到初级捕获抗体; 用荧光材料标记的结合二次捕获抗体结合到β-淀粉样蛋白上形成复合物的磁性颗粒; 将复合物设置在光电流根据入射光量变化的光场效应晶体管的沟道区域中; 并测量由复合物激发的光改变的光电流，以量化存在于生物材料中的β-淀粉样蛋白的浓度。 （S110）准备磁性粒子;（S120）分解含有β-淀粉样蛋白的生物材料;（S130）形成磁性粒子和多种蛋白质的复合体;（S140）在复合体的感光区域中配置复合体 效应晶体管;（S150）测量光场效应晶体管的光电流
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9.发明公开
公开(公告)号：KR1020110112177A
公开(公告)日：2011-10-12
申请号：KR1020100096495
申请日：2010-10-04
Applicant: 한국전자통신연구원
IPC: G01N33/68
Abstract: 본 발명은 거대자기저항 센서를 이용한 알츠하이머병의 진단방법 및 알츠하이머병 진단용 자기비드-다중단백질 복합체에 관한 것이다. 본 발명에 따른 거대자기저항 센서를 이용하여 알츠하이머병의 진단방법은 기존의 형광물질이나 유전자 분석 대신 거대자기저항 센서를 이용하여 간단한 방법으로 알츠하이머병을 쉽게 진단할 수 있고, 알츠하이머병 진단용 바이오 센서로 대량생산이 가능하므로, 알츠하이머병의 모니터링과 치료에 유용하게 사용할 수 있다.
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