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    마이크로 렌즈를 이용한 세포내 발병 원인 물질 측정 방법
    1.
    发明公开
    마이크로 렌즈를 이용한 세포내 발병 원인 물질 측정 방법 审中-实审
    使用微生物测量细胞中的细胞生物学物质的方法

    公开(公告)号：KR1020140077790A

    公开(公告)日：2014-06-24

    申请号：KR1020120146933

    申请日：2012-12-14

    Applicant: 한국전자통신연구원

    Inventor： 채철주 ,  송기봉

    IPC: G01N33/68 ,  G02B3/00 ,  G01N33/58 ,  G01N33/50

    Abstract: Suggested is a method for measuring etiologic substances within a cell using a microlens, capable of enabling the early detection of Alzheimer`s disease by collecting light generated from beta-amyloid within a cell underwent fluorescent staining in a phototransistor channel using the microlens. The suggested method comprises the steps of: preparing the microlens; cultivating a cell including a protein biomarker causing Alzheimer`s disease on the microlens; performing fluorescent staining the cultivated cell; and collecting light generated from the cell through the microlens in an optical sensor opposed to the microlens.

    Abstract translation: 建议使用微透镜测量细胞内的病原物质的方法，其能够通过收集细胞内的β-淀粉样蛋白产生的光，通过使用微透镜在光电晶体管通道中进行荧光染色，从而能够早期检测阿尔茨海默氏病。 所提出的方法包括以下步骤：制备微透镜; 在微透镜上培养包括引起阿尔茨海默氏病的蛋白质生物标志物的细胞; 对培养细胞进行荧光染色; 以及在与微透镜相对的光学传感器中通过微透镜收集从电池产生的光。

    포토트랜지스터를 이용한 알츠하이머 질병의 조기 진단 방법
    2.
    发明公开
    포토트랜지스터를 이용한 알츠하이머 질병의 조기 진단 방법 无效
    使用光电传感器治疗阿尔茨海默病的早期诊断方法

    公开(公告)号：KR1020110119513A

    公开(公告)日：2011-11-02

    申请号：KR1020100129333

    申请日：2010-12-16

    Applicant: 한국전자통신연구원

    Inventor： 김관수 ,  채철주 ,  강재민 ,  서정대 ,  정명애 ,  송기봉

    IPC: G01N33/68 ,  G01N27/26 ,  G01N21/84 ,  H01L21/00

    CPC classification number: G01N33/6896 ,  G01N33/54373 ,  G01N2446/00 ,  G01N2800/2821

    Abstract: PURPOSE: A method for early diagnosing Alzheimer's disease using a phototransistor is provided to enable early diagnosis of the disease and to quantitate cells or beta-amyloid proteins. CONSTITUTION: A method for early diagnosing Alzheimer's disease using a phototransistor comprises: a step of placing the phototransistor for sensing photocurrent difference according to the amount of incident light and a step of sensing photocurrent different according to cells fixed on the surface of a channel layer. The phototransistor comprises the channel layer. The cells have a protein biomarker causing Alzheimer's disease. The protein biomarker is labeled with magnetic particles(200) which are conjugated with multi-proteins. The protein biomarker is beta-amyloid protein(240).

    Abstract translation: 目的：提供一种使用光电晶体管早期诊断阿尔茨海默氏病的方法，以便早期诊断疾病并定量细胞或β-淀粉样蛋白。 构成：使用光电晶体管来早期诊断阿尔茨海默病的方法包括：根据入射光量放置用于感测光电流差的光电晶体管的步骤，以及根据固定在沟道层表面上的电池感测不同光电流的步骤。 光电晶体管包括沟道层。 细胞具有引起阿尔茨海默氏病的蛋白质生物标志物。 蛋白质生物标志物用与多蛋白结合的磁性颗粒（200）标记。 蛋白质生物标志物是β-淀粉样蛋白（240）。

    알츠하이머병 발병률 예측 장치
    5.
    发明公开
    알츠하이머병 발병률 예측 장치 审中-实审
    预测阿尔茨海默病疾病流行率的装置

    公开(公告)号：KR1020140119486A

    公开(公告)日：2014-10-10

    申请号：KR1020130035205

    申请日：2013-04-01

    Applicant: 한국전자통신연구원

    Inventor： 채철주 ,  정교일 ,  송기봉

    IPC: G01N21/64 ,  G01N33/483

    Abstract: Disclosed are a device and a method for predicting the incidence rate of the Alzheimer′s disease by utilizing a beta-amyloid concentration, a p-FET measurement value, and a PMT measurement value as input data, extracting the feature values of the input data, and applying the feature values to a pattern recognizing algorithm. The device comprises: a feature extracting part for extracting the feature values through the recognition of a pattern by comparing a beta-amyloid concentration value contained in a sample to be measured, a photosensitive field-effect transistor measurement value, and a photo multiplier tube measurement value, which are inputted from the outside, with pre-stored initial values; and an incidence rate predicting part for predicting the incidence rate of the Alzheimer′s disease based on the extracted feature values. The photosensitive field-effect transistor measurement value is obtained by measuring the photoelectric current of light emitted by exciting light while the sample in which the beta-amyloid and fluorescent substances are combined is fixed in the sensing section of a photosensitive field-effect transistor, and the photo multiplier tube measurement value is obtained by measuring the number of photons in the light emitted by exciting the light to the same sample used in the measurement of the photoelectric current.

    Abstract translation: 公开了一种通过利用β-淀粉样蛋白浓度，p-FET测量值和PMT测量值作为输入数据来预测阿尔茨海默病发病率的装置和方法，提取输入数据的特征值 并且将特征值应用于模式识别算法。 该装置包括：特征提取部分，用于通过比较待测样品中包含的β-淀粉样蛋白浓度值，光敏场效应晶体管测量值和光倍增管测量值，通过识别图案来提取特征值 值，其从外部输入预先存储的初始值; 以及基于提取的特征值来预测阿尔茨海默病发病率的发生率预测部分。 光敏场效应晶体管测量值是通过测量激发光发射的光的光电流而得到的，而其中组合β-淀粉样蛋白和荧光物质的样品固定在感光场效应晶体管的感测部分中，以及 光电倍增管测量值是通过测量通过将光激发到与光电流测量中使用的相同样品发出的光中的光子数来获得的。

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