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1.发明授权
公开(公告)号：KR100137687B1
公开(公告)日：1998-05-15
申请号：KR1019950002621
申请日：1995-02-13
IPC: C07D313/18 , A61K31/335
Abstract: 본 발명은 항암효과를 갖는 신규의 지방산락톤(Fatty Acid Lactones) 유도체 및 그 추출방법에 관한 것으로, 본 발명에 의한 지방산락톤 유도체는, 아래의 구조식(Ⅰ) 및 (Ⅱ)와 같이 이루어져 있고, 강장동물, 특히 히드라(Hydroid) 솔란데리아 세쿤다(Solanderia Secunda)로부터 유기용매로 용출하여 크로마토그래피 방법에 의해 분리추출하며, 파내실 단백질 전이효소(Farnesyl Protein Transferase)의 작용을 저해하여 Ras 유전자의 파내실화를 방지하는 기능을 함으로써 항암작용을 하는 것으로 밝혀진 것이다.
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2.发明公开
公开(公告)号：KR1019960031583A
公开(公告)日：1996-09-17
申请号：KR1019950002621
申请日：1995-02-13
IPC: C07D313/18 , A61K31/335
Abstract: 본 발명은 항암효과를 갖는 신규의 지방산락톤(fatty acid lactones) 유도체 및 그 추출방법에 관한 것으로, 본 발명에 의한 지방산락톤 유도체는, 아래의 구조식(I) 및 (Ⅱ)와 같이 이루어져 있고, 강장동물, 특히 히드라(hydroid) 솔란데리아 세쿤다(Solanderia secunda)로부터 유기용매로 용출하여 크로마토그래피 방법에 의해 분리추출하며, 파내실 단백질 전이효소(farnesyl protein transferase)의 작용을 저해하여 Ras 유전자의 파내실화를 방지하는 기능을 함으로써 항암작용을 하는 것으로 밝혀진 것이다.
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公开(公告)号：KR100896268B1
公开(公告)日：2009-05-08
申请号：KR1020080027192
申请日：2008-03-25
Applicant: 한국해양연구원
IPC: C07C39/367 , C07C37/02
Abstract: 본 발명은 신규한 브로모페놀계 화합물, 그 제조방법 및 이를 유효성분으로 포함하는 항균 조성물에 관한 것이다. 상기 신규한 브로모페놀계 화합물은 기존에 알려진 화합물에 비하여 그람 양성균 및 그람 음성균에 속하는 위해세균 특히, 스테필로코코스속 균(
Staphylococcus . sp), 바실러스속 균(
Bacillus . sp), 마이크로커커스속 균(
Micrococcus . sp), 프로테우스속 균(
Proteus . sp) 및 살모넬라속 균(
Salmonella . sp)에 대하여 우수한 항균활성을 갖는 항균 조성물에 관한 것이다.
브로모페놀계 화합물, 항균 조성물-
公开(公告)号：KR1020030080580A
公开(公告)日：2003-10-17
申请号：KR1020020019278
申请日：2002-04-09
Applicant: 한국해양연구원
Abstract: PURPOSE: A method for reducing the toxicity of PCBs by reducing all chlorine atoms contained in PCBs (polychlorinated biphenyls) by using hydrogen, thereby converting the polychlorinated biphenyls into biphenyl. CONSTITUTION: The method comprises a step of mixing methanol solution saturated with sodium with a solution into which PCBs (polychlorinated biphenyls) is dissolved; a step of adding palladium-alumina catalyst to a mixed solution in which the PCBs solution is mixed with the methanol solution; and a step of applying ultrasonic waves to the mixed solution to which the palladium-alumina catalyst is added, wherein toxicity of chlorine molecules of PCBs is reduced by increasing activity of the palladium-alumina catalyst using ultrasonic waves, thereby stably conducting chemical reaction in which chlorine atoms of the PCBs are replaced with hydrogen of sodium formate.
Abstract translation: 目的：通过使用氢气降低多氯联苯（多氯联苯）中所含的所有氯原子，从而将多氯联苯转化为联苯来降低PCBs毒性的方法。 构成：该方法包括将饱和的甲醇溶液与溶解有多氯联苯（多氯联苯）的溶液混合的步骤; 在其中将PCB溶液与甲醇溶液混合的混合溶液中加入钯 - 氧化铝催化剂的步骤; 以及向加入了钯 - 氧化铝催化剂的混合溶液施加超声波的步骤，其中通过使用超声波增加钯 - 氧化铝催化剂的活性来降低PCB的氯分子的毒性，从而稳定地进行化学反应，其中 PCB的氯原子被甲酸钠的氢替代。
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公开(公告)号：KR1020020087518A
公开(公告)日：2002-11-23
申请号：KR1020010025737
申请日：2001-05-11
Applicant: 한국해양연구원
IPC: C07D493/08
Abstract: PURPOSE: Provided are a biostimulating material derived from Actinomyces, an extracting method thereof and a pharmaceutical composition containing the same. The biostimulating material has toxicity to various cancer cells, so that it can be useful as an anticancer drug. CONSTITUTION: The biostimulating material derived from Actinomyces is represented by formula(1), in which R1 and R2 are the same or different, and hydrogen, methyl, ethyl, propyl or isopropyl. The method for extracting the biostimulating material derived from Actinomyces comprises the steps of: culturing Streptomyces sp. in a broth; filtering the cultured medium to isolate a mycelium; extracting the mycelium with at least one of methanol, ethanol, chloroform, acetone and dichloromethane; evaporating the crude extract solution under reduced pressure to obtain a residue; fractionating the residue according to its polarity; evaporating a polar fraction under reduced pressure to obtain a polar organic concentrate; and subjecting the polar organic concentrate to chromatography.
Abstract translation: 目的：提供衍生自放线菌属的生物刺激材料，其提取方法和含有它的药物组合物。 生物刺激材料对各种癌细胞具有毒性，因此可用作抗癌药物。 构成：源自放线菌属的生物刺激材料由式（1）表示，其中R 1和R 2相同或不同，以及氢，甲基，乙基，丙基或异丙基。 提取衍生自放线菌的生物刺激物质的方法包括以下步骤：培养链霉菌属（Streptomyces sp。 在肉汤 过滤培养的培养基以分离菌丝体; 用甲醇，乙醇，氯仿，丙酮和二氯甲烷中的至少一种萃取菌丝体; 在减压下蒸发粗提液，得到残渣; 残留物根据其极性进行分馏; 在减压下蒸发极性馏分以获得极性有机浓缩物; 并将极性有机浓缩物进行色谱分离。
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Patent Agency Ranking
公开(公告)号：KR1020010087678A
公开(公告)日：2001-09-21
申请号：KR1020000011560
申请日：2000-03-08
Applicant: 한국해양연구원
IPC: C07D493/04
Abstract: PURPOSE: Novel compounds, acalycixeniolide C, D, E and F, isolated from Acalycigorgia inermis and a producing method thereof are provided. The acalycixeniolides inhibit the growth of leukemia, and is thus used for the treatment of cancers. CONSTITUTION: The method for producing acalycixeniolide C represented by formula (1), acalycixeniolide D represented by formula (2), acalycixeniolide E represented by formula (3), and acalycixeniolide F represented by formula (4) comprises the steps of: extracting Acalycigorgia inermis with organic solvents to produce the crude extract; removing the solvent from the crude extract by heating it under reduced pressure to collect remaining substances; fractionating the remaining substances according to their polarity; removing the solvent from the fractionated polar substances by heating them under reduced pressure; and isolating and purifying the polar substances.
Abstract translation: 目的：提供从Acalycigorgia inermis分离的新型化合物，acalyciseniolide C，D，E和F及其制备方法。 阿卡西诺二酸盐抑制白血病的生长，因此用于治疗癌症。 构成：由式（1）表示的阿卡西力德C，由式（2）表示的阿卡霉烯二醇D，式（3）表示的阿卡洛利烯酸E和式（4）表示的阿卡洛沙尼英F的方法包括以下步骤： 用有机溶剂生产粗提物; 通过在减压下加热溶剂从粗提取物中除去溶剂以收集剩余物质; 根据其极性对其余物质进行分级; 通过在减压下加热它们从分级极性物质中除去溶剂; 并分离和纯化极性物质。
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公开(公告)号：KR1019990074315A
公开(公告)日：1999-10-05
申请号：KR1019980007815
申请日：1998-03-10
Applicant: 한국해양연구원
Abstract: 본 발명은 DNA 염기 서열을 이용한 미생물에의 표지 부착방법에 관한 것으로, 본 발명에 따른 미생물에의 표지 부착방법은, 원하는 이름표의 영문 문자열에 해당하는 DNA 염기 서열을 제작하는 단계; 제작된 문자열 염기 서열을 리게이션시켜 일련의 문자열을 만드는 단계; 문자열의 양쪽에 PCR(Polymerase Chain Reaction)용 프라이머(primer)를 부착하고 그 바깥쪽에 적당한 벡터와 리게이션할 수 있는 리스트릭션 사이트(restriction site)를 붙이는 단계; 이를 제한 효소로 처리하여 스티키 엔드(sticky end)를 만드는 단계 ; 이를 동일한 제한 효소로 처리된 벡터에 삽입하는 단계; 벡터를 원하는 미생물에 형질전환시키는 단계를 포함하여 구성되는 것을 특징으로 하여, 생물학적 오염물질의 해당 생물 폐기물에 이름표를 부착하게 하거나 개발한 기관의 영문 명칭을 표지할 수 있게 함으로써 해당 영문 명칭을 알아낼 수 있어 폐기물 등의 책임소재를 밝힐 수 있을 뿐만 아니라, 새로운 유전자를 클로닝한 플라즈마나 벡터를 개발하였을 때에도 이름표를 부착하여 그 소유권을 명시할 수 있어 미생물 이용과 관련된 분쟁의 소지를 미연에 방지할 수 있는 DNA 염기 서열을 이용한 미생물에의 표지 부착방법을 제공한다.
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公开(公告)号：KR1020040008011A
公开(公告)日：2004-01-28
申请号：KR1020020041303
申请日：2002-07-15
Applicant: 한국해양연구원
CPC classification number: A62D3/30 , A62D3/13 , A62D2101/40 , B01J21/04 , B01J23/44
Abstract: PURPOSE: Provided is a method for reducing or removing the toxicity of dioxin by converting highly toxic dioxins into non-toxic materials without using any expensive equipments, while recovering and reutilizing the used catalyst. CONSTITUTION: The method comprises the steps of: adding a formate salt and a palladium-alumina catalyst to a solution in which a dioxin is dissolved; and applying an ultrasonic wave to the mixed solution. Particularly, the dioxin is polychlorinated dibenzo-p-dioxin(PCDDs), and the formate salt is potassium formate. In the method, the chlorine atoms in PCDDs are substituted with hydrogen atom so that PCDDs are converted into dibenzo-p-dioxin.
Abstract translation: 目的：提供一种减少或去除二恶英毒性的方法，将二恶英毒性转化为无毒物质，无需任何昂贵的设备，同时回收和再利用所用的催化剂。 方法：该方法包括以下步骤：将甲酸盐和钯 - 氧化铝催化剂加入二恶英溶解的溶液中; 并向混合溶液施加超声波。 特别地，二恶英是多氯二苯并对二恶英（PCDDs），甲酸盐是甲酸钾。 在该方法中，PCDD中的氯原子被氢原子取代，使得PCDD转化为二苯并对二恶英。
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公开(公告)号：KR100404580B1
公开(公告)日：2003-11-05
申请号：KR1020010019347
申请日：2001-04-11
Applicant: 한국해양연구원
IPC: C07D405/04
CPC classification number: C07D405/06
Abstract: The present invention provides Wondonin A of general formula (I), which is extracted from a two-sponge association of phylum Porifera (sponge) and has antiangiogenic activity, and a process for preparing the same. Wondonin A has no cytotoxicity, but has an inhibitory activity against angiogenesis which is one of the crucial mechanisms of cancer cell metastasis, thus, it can be applied not only as an anticancer drug but also as a therapeutic agent of angiogenesis-associated diseases such as cardiac ischemia, rheumatoid arthritis, and diabetes mellitus.
Abstract translation: 本发明提供通式（I）的维金素A及其制备方法，其从海绵门（海绵）的双海绵组合物提取并具有抗血管生成活性。 Wondonin A不具有细胞毒性，但对血管生成具有抑制活性，这是癌细胞转移的关键机制之一，因此它不仅可用作抗癌药物，而且还可用作血管生成相关疾病的治疗剂，如 心脏局部缺血，类风湿性关节炎和糖尿病。
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公开(公告)号：KR1020010018962A
公开(公告)日：2001-03-15
申请号：KR1019990035141
申请日：1999-08-24
Applicant: 한국해양연구원
IPC: C07F9/10
CPC classification number: C07F9/10
Abstract: PURPOSE: A method for manufacturing phosphorylcholine having two different unsaturated fatty acids is provided to reduce the generation of by-products and to improve a low production yield by using fatty acid imidazolide or anhydride instead of fatty acid chloride. CONSTITUTION: Phosphorylcholine having two different unsaturated fatty acids represented by the formula (II) is manufactured by the following steps of: i) reacting unsaturated fatty acid of the formula (II) with N,N-carbonyldiimidazole of the formula (III), in the presence of organic solvent, to obtain fatty acid imidazolide of the formula (IV) and reacting fatty acid imidazolide of the formula (IV) with sn-glycero-3-phosphorylcholine-Cdcl2 of the formula (V), in the presence of organic base, to synthesize 1-acyl-sn-glycero-3-phosphocholine of the formula (VI); ii) reacting 1-acyl-sn-glycero-3-phosphocholine of the formula (VI) with unsaturated fatty acid of the formula (VII), in the presence of organic solvent and bases, to obtain phosphorylcholine of the formula (I) having two different unsaturated fatty acids. Equation).
Abstract translation: 目的：提供具有两种不同不饱和脂肪酸的磷酸胆碱的制备方法，以减少副产物的产生，并通过使用脂肪酸咪唑啉酮或酸酐代替脂肪酰氯来提高低产量。 构成：具有由式（II）表示的两种不同不饱和脂肪酸的磷酰胆碱通过以下步骤制备：i）使式（II）的不饱和脂肪酸与式（III）的N，N-羰基二咪唑反应， 有机溶剂的存在，得到式（Ⅳ）的脂肪酸咪唑啉并使式（Ⅳ）的脂肪酸咪唑与式（Ⅴ）的sn-甘油基-3-磷酸胆碱-Cdcl2在有机物存在下反应 碱合成式（VI）的1-酰基-sn-甘油基-3-磷酸胆碱; ii）使式（VI）的1-酰基-sn-甘油基-3-磷酸胆碱与式（VII）的不饱和脂肪酸在有机溶剂和碱存在下反应，得到式（I）的磷酸胆碱，其具有式 两种不同的不饱和脂肪酸。 方程）。
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