-
公开(公告)号：KR102145939B1
公开(公告)日：2020-08-20
申请号：KR1020180130956
申请日：2018-10-30
Applicant: 한국화학연구원
IPC: C09K21/06 , C07C315/06 , C07C317/14
-
2.发明授权
公开(公告)号：KR101209889B1
公开(公告)日：2012-12-10
申请号：KR1020100045593
申请日：2010-05-14
IPC: A61K36/232 , A61K31/37 , A61P3/04 , A61P3/00
Abstract: 본발명은당귀의주성분인데쿠르신으로부터합성된유도체인데쿠시놀벤조에이트(Decursinol benzoate)를이용한비만예방용또는비만치료용조성물에관한것으로써, 보다상세하게는상기데쿠시놀벤조네이트는 AMPK(5' adenosine monophosphate-activated protein kinase)활성능을가짐으로써지방산합성을억제하는것을특징으로갖거나, PPAR-GAMMA(Peroxisome proliferator-activated receptor gamma)의발현및 전사활성을억제하는것을특징으로가질수 있다.
-
3.发明公开
公开(公告)号：KR1020110125940A
公开(公告)日：2011-11-22
申请号：KR1020100045593
申请日：2010-05-14
IPC: A61K36/232 , A61K31/37 , A61P3/04 , A61P3/00
CPC classification number: A61K36/232 , A61K31/216 , A61K31/235 , A61K31/366 , Y10S514/909
Abstract: PURPOSE: A composition containing derivatives synthesized from decursin for preventing or treating obesity is provided to suppress fatty acid synthesis. CONSTITUTION: A composition for preventing or treating obesity contains decursinol benzoate which is synthedized from decursin. The decursinol benzoate suppresses fatty acid synthesis by AMPK(5' adenosine monophosphate-activated protein kinase) activity. A method for synthesizing decursinol benzoate comprises: a step of performing enfleurage of dried Angelicae gigantis Radix in methanol at room temperature for seven days and filtering; a step of suspending the methanol extract in distilled water and isolating dichloromethane; and a step of freeze-drying and performing silicagel column chromatography to prepare six fraction.
Abstract translation: 目的：提供含有由前代素合成的用于预防或治疗肥胖症的衍生物的组合物以抑制脂肪酸合成。 构成：用于预防或治疗肥胖症的组合物含有由前胡素合成的去甲基苯甲酸酯。 苯酚去甲酚抑制AMPK（5'腺苷单磷酸激活蛋白激酶）活性的脂肪酸合成。 合成前酚醇苯甲酸酯的方法包括：在室温下在甲醇中进行七天的过滤干燥的当归香草， 将甲醇提取物悬浮在蒸馏水中并分离二氯甲烷的步骤; 和冷冻干燥并进行硅胶柱色谱以制备6份。
-
-
Search Results
3
records
(took 0.017 seconds)
