公开(公告)号：KR1020110089463A

公开(公告)日：2011-08-08

申请号：KR1020117017501

申请日：2007-07-24

Applicant: 한국화학연구원

Inventor： 구오홍얀 ,  김정유 ,  이일영 ,  미첼마이클엘 ,  손종찬 ,  쭈리안홍 ,  키르쉬베르그토르스텐에이.

IPC: C07D413/06 ,  C07D401/06 ,  A61K31/513 ,  A61P31/18

CPC classification number: C07D401/06 ,  C07D239/54 ,  C07D403/06 ,  C07D413/06

Abstract: PURPOSE: A novel HIV reverse transcriptase inhibitor is provided to ensure an antiviral effect and to treat diseases such as AIDS. CONSTITUTION: A novel HIV reverse transcriptase inhibitor compound is denoted by chemical formula I or II. In the chemical formulas, X and Y are independently O; X is -F, -Cl, -Br, or -I; A is -O-, -S-, NR^5 or -C(R^6)_2-; D is alkylene or substituted alkylene; and L is covalent bond, alkylene, substituted alkylene, alkenylene, or substituted alkenylene. A medicinal composition for preventing or treating HIV infection, AIDS or AIDS complication contains a compound of chemical formula I, II, or III, pharmaceutically acceptable salt, solvate, and/or ester.

Abstract translation: 目的：提供一种新的HIV逆转录酶抑制剂，以确保抗病毒作用并治疗艾滋病等疾病。 构成：一种新的HIV逆转录酶抑制剂化合物由化学式I或II表示。 在化学式中，X和Y独立地为O; X是-F，-Cl，-Br或-I; A是-O - ， - S - ，NR 5或-C（R 6）2 - ; D是亚烷基或取代的亚烷基; L是共价键，亚烷基，取代的亚烷基，亚烯基或取代的亚烯基。 用于预防或治疗HIV感染，AIDS或AIDS并发症的药用组合物含有化学式I，II或III的化合物，药学上可接受的盐，溶剂化物和/或酯。