公开(公告)号：KR1020110089463A

公开(公告)日：2011-08-08

申请号：KR1020117017501

申请日：2007-07-24

Applicant: 한국화학연구원

Inventor： 구오홍얀 ,  김정유 ,  이일영 ,  미첼마이클엘 ,  손종찬 ,  쭈리안홍 ,  키르쉬베르그토르스텐에이.

IPC: C07D413/06 ,  C07D401/06 ,  A61K31/513 ,  A61P31/18

CPC classification number: C07D401/06 ,  C07D239/54 ,  C07D403/06 ,  C07D413/06

Abstract: PURPOSE: A novel HIV reverse transcriptase inhibitor is provided to ensure an antiviral effect and to treat diseases such as AIDS. CONSTITUTION: A novel HIV reverse transcriptase inhibitor compound is denoted by chemical formula I or II. In the chemical formulas, X and Y are independently O; X is -F, -Cl, -Br, or -I; A is -O-, -S-, NR^5 or -C(R^6)_2-; D is alkylene or substituted alkylene; and L is covalent bond, alkylene, substituted alkylene, alkenylene, or substituted alkenylene. A medicinal composition for preventing or treating HIV infection, AIDS or AIDS complication contains a compound of chemical formula I, II, or III, pharmaceutically acceptable salt, solvate, and/or ester.

Abstract translation: 目的：提供一种新的HIV逆转录酶抑制剂，以确保抗病毒作用并治疗艾滋病等疾病。 构成：一种新的HIV逆转录酶抑制剂化合物由化学式I或II表示。 在化学式中，X和Y独立地为O; X是-F，-Cl，-Br或-I; A是-O - ， - S - ，NR 5或-C（R 6）2 - ; D是亚烷基或取代的亚烷基; L是共价键，亚烷基，取代的亚烷基，亚烯基或取代的亚烯基。 用于预防或治疗HIV感染，AIDS或AIDS并发症的药用组合物含有化学式I，II或III的化合物，药学上可接受的盐，溶剂化物和/或酯。

公开(公告)号：KR1020090040449A

公开(公告)日：2009-04-24

申请号：KR1020097003836

申请日：2007-07-24

Applicant: 한국화학연구원

Inventor： 구오홍얀 ,  김정유. ,  이일영 ,  미첼마이클엘. ,  손종찬 ,  쭈리안홍 ,  키르쉬베르그토르스텐에이.

IPC: C07D413/06 ,  C07D239/54 ,  A61K31/513 ,  A61P31/00

CPC classification number: C07D401/06 ,  C07D239/54 ,  C07D403/06 ,  C07D413/06

Abstract: An HIV(human immunodeficiency virus) reverse transcriptase inhibitors for suppressing and treating HIV infection of human bodies is provided to inhibit and treat the HIV infection by suppressing HIV reverse transcriptase in wild type and mutation strain of HIV. A pharmaceutical composition for suppressing and treating HIV infection of human bodies comprises a compound of the chemical formula (I), the chemical formula (II) or the chemical formula (III) or pharmaceutically acceptable salts, solvate and/or ester. The composition further includes at least one kind of additional active pharmaceutical agents. The additional active pharmaceutical agent is an HIV protease inhibiting compound, non-nucleoside inhibitor of HIV reverse transcriptase, nucleoside inhibitor of HIV reverse transcriptase, nucleotide inhibitor, HIV integrase inhibitor, gp41 inhibitor, CXCR4 inhibitor, entry inhibitor, gp120 inhibitor, G6PD and NADH- oxydase inhibitor, CCR5 inhibitor, and drug for treating HIV or their mixture.

Abstract translation: 提供用于抑制和治疗人体HIV感染的HIV（人类免疫缺陷病毒）逆转录酶抑制剂，以通过抑制艾滋病毒的野生型和突变株中的HIV逆转录酶来抑制和治疗HIV感染。 用于抑制和治疗人体HIV感染的药物组合物包括化学式（I），化学式（II）或化学式（III）的化合物或其药学上可接受的盐，溶剂合物和/或酯。 组合物还包括至少一种其它活性药剂。 另外的活性药剂是HIV蛋白酶抑制化合物，HIV逆转录酶的非核苷抑制剂，HIV逆转录酶的核苷抑制剂，核苷酸抑制剂，HIV整合酶抑制剂，gp41抑制剂，CXCR4抑制剂，进入抑制剂，gp120抑制剂，G6PD和NADH - 氧化酶抑制剂，CCR5抑制剂和用于治疗HIV或其混合物的药物。