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    아미노피라졸 유도체, 이의 제조 방법 및 이를 함유하는허혈성 질환의 예방 또는 치료용 조성물
    2.
    发明公开
    아미노피라졸 유도체, 이의 제조 방법 및 이를 함유하는허혈성 질환의 예방 또는 치료용 조성물 有权
    氨基吡唑衍生物，其制备方法以及用于预防或治疗含有其的异种疾病的组合物

    公开(公告)号：KR1020080037911A

    公开(公告)日：2008-05-02

    申请号：KR1020060105183

    申请日：2006-10-27

    Applicant: 한국화학연구원

    Inventor： 서지희 ,  유성은 ,  이규양 ,  김낙정 ,  나윤정 ,  김은희 ,  정용삼 ,  이윤숙

    IPC: C07D207/16 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

    CPC classification number: C07D231/38 ,  C07D231/40 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

    Abstract: Aminopyrazole derivatives are provided to reduce ischemic apoptosis significantly and protect internal organs, so that the derivatives are useful for preventing or treating ischemic diseases mediated by ischemic apoptosis. The aminopyrazole derivatives represented by the formula(1) or pharmaceutically acceptable salts are provided in order to prevent or treat ischemic diseases, wherein R^1 is -CO2R^3, -CH2OR^3, -CONR^3R^4 or a structural formula in which R^3 and R^4 are each independently H or C1-C6 linear, branched or cyclic alkyl; R^2 is -(CH2)m Ar or C1-C6 linear, branched or cyclic alkyl in which m is an integer from 1 to 3 and Ar is phenyl or C1-C3 alkyl or halogen substituted phenyl; B is H, phenyl or C1-C3 alkyl or halogen substituted phenyl; n is an integer from 0 to 2; Y is S, O, C, SO, SO2 or NR^3R^4; Z is H, halogen, OCH3, NO2, NH2 or C1-C3 linear or branched alkyl; and A is CH or N.

    Abstract translation: 提供氨吡唑衍生物以显着减少缺血性凋亡并保护内脏，使得该衍生物可用于预防或治疗缺血性细胞凋亡介导的缺血性疾病。 提供由式（1）表示的氨基吡唑衍生物或其药学上可接受的盐，以便预防或治疗缺血性疾病，其中R 1是-CO 2 R 3，-CH 2 OR 3，-CONR 3 3R 4或结构式 其中R 3和R 4各自独立地为H或C 1 -C 6直链，支链或环状烷基; R 2是 - （CH 2）m Ar或C 1 -C 6直链，支链或环状烷基，其中m是1至3的整数，Ar是苯基或C 1 -C 3烷基或卤素取代的苯基; B是H，苯基或C 1 -C 3烷基或卤素取代的苯基; n为0〜2的整数; Y是S，O，C，SO，SO 2或NR 3 3R 4; Z是H，卤素，OCH 3，NO 2，NH 2或C 1 -C 3直链或支链烷基; A是CH或N.

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