公开(公告)号：KR1020020001905A

公开(公告)日：2002-01-09

申请号：KR1020000023327

申请日：2000-05-01

Applicant: 한국화학연구원 ,  주식회사 아이씨켐

Inventor： 이병민 ,  강호철 ,  윤정호 ,  장주영 ,  이종봉

IPC: C07C41/01

CPC classification number: C07D303/22

Abstract: PURPOSE: A method for preparing glycidyl ether compound is provided, to improve the production yield without a solvent by controlling the content ratio of an alcohol, epichlorohydrin, a phase transfer catalyst and an alkali metal a base. CONSTITUTION: The method comprises the steps of reacting an alcohol with epichlorohydrin without a solvent in the presence of an alkali metal base and an ammonium-based phase transfer catalyst. Preferably the glycidyl ether compound is an alkyl glycidyl ether represented by the formula 1a or a 1,3-dialkoxy-2-propanol represented by the formula 1b, wherein R1 and R2 are independent each other and is a saturated or unsaturated alkyl group or aromatic group containing the carbon chain or the carbon fluoride chain. Preferably the alcohol is primary, secondary or tertiary alcohol containing a saturated or unsaturated alkyl group of an aromatic group. The phase transfer catalyst is selected from an amine compound and an ammonium compound. The ratio of an alcohol, epichlorohydrin and a base is 1 : 0.8-4 : 0.8-4 by mol in the case of alkyl glycidyl ether of the formula 1a. And the ratio of an alcohol, epichlorohydrin and a base is 1 : 0.12-0.7 : 0.2-4 by mol in the case of 1,3-dialkoxy-2-propanol of the formula 1b. The ratio of a phase transfer catalyst to an alcohol is 0.0005-0.1 by mol.

Abstract translation: 目的：提供缩水甘油醚化合物的制备方法，通过控制醇，表氯醇，相转移催化剂和碱金属碱的含量比，提高无溶剂的产率。 构成：该方法包括在碱金属碱和铵基相转移催化剂存在下，不用溶剂使醇与表氯醇反应的步骤。 优选地，缩水甘油醚化合物是由式1a表示的烷基缩水甘油醚或由式1b表示的1,3-二烷氧基-2-丙醇，其中R 1和R 2彼此独立并且是饱和或不饱和的烷基或芳族 含有碳链或碳氟链的基团。 优选地，醇是含有芳族基团的饱和或不饱和烷基的伯，仲或叔醇。 相转移催化剂选自胺化合物和铵化合物。 在式1a的烷基缩水甘油醚的情况下，醇，表氯醇和碱的比例为1:0.8-4:0.8-4摩尔。 在式1b的1,3-二烷氧基-2-丙醇的情况下，醇，表氯醇和碱的比例为1:0.1-0.7:0.2-4摩尔。 相转移催化剂与醇的比例为0.0005-0.1摩尔％。

公开(公告)号：KR101667563B1

公开(公告)日：2016-10-28

申请号：KR1020150047057

申请日：2015-04-02

Applicant: 한국화학연구원

Inventor： 이병호 ,  이규양 ,  임채조 ,  서지희 ,  오광석 ,  이정현 ,  장주영

IPC: C07D417/12 ,  C07D417/10 ,  A61K31/433 ,  A23L1/30

Abstract: 본발명은 1,3,4-싸이아다이아졸-2-아민유도체, 이의제조방법, 및이를유효성분으로포함하는유로텐신-Ⅱ수용체활성관련질환의예방또는치료용약학적조성물에관한것이다. 본발명에따른 1,3,4-싸이아다이아졸-2-아민유도체는유로텐신-Ⅱ수용체에대한길항제로작용함으로써울혈성심부전, 심장허혈, 심근경색, 심장비대증, 심장섬유증, 관상동맥질환, 동맥경화증, 고혈압, 천식, 신부전, 당뇨병, 혈관염증, 신경퇴행성질환, 뇌졸중, 통증, 우울증, 정신병, 암등과같은유로텐신-Ⅱ수용체활성관련질환을예방또는치료하는데유용하게사용할수 있다.

公开(公告)号：KR1020160118645A

公开(公告)日：2016-10-12

申请号：KR1020150047057

申请日：2015-04-02

Applicant: 한국화학연구원

Inventor： 이병호 ,  이규양 ,  임채조 ,  서지희 ,  오광석 ,  이정현 ,  장주영

IPC: C07D417/12 ,  C07D417/10 ,  A61K31/433 ,  A23L1/30

Abstract: 본발명은 1,3,4-싸이아다이아졸-2-아민유도체, 이의제조방법, 및이를유효성분으로포함하는유로텐신-Ⅱ수용체활성관련질환의예방또는치료용약학적조성물에관한것이다. 본발명에따른 1,3,4-싸이아다이아졸-2-아민유도체는유로텐신-Ⅱ수용체에대한길항제로작용함으로써울혈성심부전, 심장허혈, 심근경색, 심장비대증, 심장섬유증, 관상동맥질환, 동맥경화증, 고혈압, 천식, 신부전, 당뇨병, 혈관염증, 신경퇴행성질환, 뇌졸중, 통증, 우울증, 정신병, 암등과같은유로텐신-Ⅱ수용체활성관련질환을예방또는치료하는데유용하게사용할수 있다.

Abstract translation: 本发明是1,3,4-恶二唑-2-林啊衍生物，其制备方法，和硬骨鱼紧张受体-Ⅱ预防或治疗的物质，其包括相同的作为活性成分的活性相关的疾病的药物组合物。 1,3,4-恶二唑-2-林啊胺衍生物根据本发明尾加压素-Ⅱ充血性心脏衰竭通过作为拮抗剂为受体，心脏局部缺血，心肌梗死，心脏肥大，心脏纤维化，冠状动脉病 ，动脉粥样硬化，高血压，哮喘，肾功能衰竭，糖尿病，血管炎症，神经变性疾病，中风，疼痛，尾加压素-Ⅱ受体活性相关的疾病，如抑郁症，精神病，癌症可以是用于预防或治疗是有用的。

公开(公告)号：KR100458793B1

公开(公告)日：2004-12-03

申请号：KR1020000023327

申请日：2000-05-01

Applicant: 한국화학연구원 ,  주식회사 아이씨켐

Inventor： 이병민 ,  강호철 ,  윤정호 ,  장주영 ,  이종봉

IPC: C07C41/01

CPC classification number: C07D303/22

Abstract: The present invention relates to a method of synthesizing glycidyl ether compounds without the addition of solvent. In particular, the present invention provides the improved preparation of the glycidyl ethers by using fatty alcohols with epichlorohydrin in the presence of alkali metal hydroxide and phase-transfer catalysts in the appropriate molar ratios of them without water and organic solvents.

Abstract translation: 本发明涉及不加溶剂合成缩水甘油醚化合物的方法。 特别地，本发明通过使用脂肪醇与表氯醇在碱金属氢氧化物和相转移催化剂的存在下以适当的摩尔比在没有水和有机溶剂的情况下提供改进的缩水甘油醚的制备。