公开(公告)号：KR100381716B1

公开(公告)日：2003-04-26

申请号：KR1020000059346

申请日：2000-10-09

Applicant: 한국화학연구원

Inventor： 심영기 ,  한광판 ,  왕진준 ,  이정옥 ,  김은주

IPC: C07D417/14

Abstract: PURPOSE: Provided are acridine derivatives having an anticancer activity, their pharmaceutically acceptable salts, their manufacturing method and their use for an anticancer agent. CONSTITUTION: The acridine derivative is represented by the formula(1) and has an anticancer activity and low toxicity, wherein X1 and X2 are the same or different from each other and represent methylene(CH2) or hetero atom; R1, R2 and R3 are the same or different from each other and represent hydrogen atom or C1-6 linear, branched or circular alkyl; and R4 and R3 are the same or different from each other and represent hydrogen atom, C1-6 linear, branched or circular alkyl, phenyl or hetero aromatic group including a hetero atom.

Abstract translation: 用途：提供具有抗癌活性的吖啶衍生物，其药学上可接受的盐，其制备方法和它们在抗癌剂中的用途。 构成：吖啶衍生物由式（1）表示，具有抗癌活性和低毒性，其中X1和X2彼此相同或不同，代表亚甲基（CH2）或杂原子; R1，R2和R3彼此相同或不同，并且表示氢原子或C1-6直链，支链或环状烷基; R4和R3彼此相同或不同，并且表示氢原子，C1-6直链，支链或环状烷基，苯基或包含杂原子的杂芳族基团。

公开(公告)号：KR1020020028391A

公开(公告)日：2002-04-17

申请号：KR1020000059346

申请日：2000-10-09

Applicant: 한국화학연구원

Inventor： 심영기 ,  한광판 ,  왕진준 ,  이정옥 ,  김은주

IPC: C07D417/14

Abstract: PURPOSE: Provided are acridine derivatives having an anticancer activity, their pharmaceutically acceptable salts, their manufacturing method and their use for an anticancer agent. CONSTITUTION: The acridine derivative is represented by the formula(1) and has an anticancer activity and low toxicity, wherein X1 and X2 are the same or different from each other and represent methylene(CH2) or hetero atom; R1, R2 and R3 are the same or different from each other and represent hydrogen atom or C1-6 linear, branched or circular alkyl; and R4 and R3 are the same or different from each other and represent hydrogen atom, C1-6 linear, branched or circular alkyl, phenyl or hetero aromatic group including a hetero atom.

Abstract translation: 目的：提供具有抗癌活性的吖啶衍生物，其药学上可接受的盐，其制备方法及其抗癌剂的用途。 构成：吖啶衍生物由式（1）表示，具有抗癌活性和低毒性，其中X1和X2彼此相同或不同，表示亚甲基（CH2）或杂原子; R1，R2和R3彼此相同或不同，表示氢原子或C1-6直链，支链或环烷基; 并且R 4和R 3彼此相同或不同，表示氢原子，C 1-6直链，支链或环烷基，包括杂原子的苯基或杂芳基。