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公开(公告)号：KR100441901B1
公开(公告)日：2004-07-27
申请号：KR1020010039222
申请日：2001-07-02
IPC: C07D501/57
Abstract: PURPOSE: Provided is an improved process for the preparation of cephalosporin derivatives from (cis)-3-acetoxypropen-cephalosporinic acid in higher yield. CONSTITUTION: The improved process for the preparation of cephalosporin derivative of the formula(1) comprises the steps of: radical reaction of a compound of the formula(5) with benzenthiol and azobisisobutyronitrile as a radical initiator in an organic solvent to convert it into a trans form; continuous reaction of the reaction product with a compound of the formula(10) to obtain a compound of the formula(3); and reaction of the compound of the formula(3) with an acylated compound of the formula(8) and a silylated compound of the formula(9).
Abstract translation: 目的：提供一种由（顺式）-3-乙酰氧基丙烯酸头孢菌素酸以较高产率制备头孢菌素衍生物的改进方法。 构成：制备式（1）头孢菌素衍生物的改进方法包括以下步骤：将式（5）化合物与苯硫醇和偶氮二异丁腈作为自由基引发剂在有机溶剂中进行自由基反应，将其转化为 转变; 使反应产物与式（10）化合物连续反应，得到式（3）化合物; 和式（3）化合物与式（8）酰化化合物和式（9）甲硅烷基化化合物的反应。
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公开(公告)号：KR1020030002925A
公开(公告)日：2003-01-09
申请号：KR1020010039222
申请日：2001-07-02
IPC: C07D501/57
Abstract: PURPOSE: Provided is an improved process for the preparation of cephalosporin derivatives from (cis)-3-acetoxypropen-cephalosporinic acid in higher yield. CONSTITUTION: The improved process for the preparation of cephalosporin derivative of the formula(1) comprises the steps of: radical reaction of a compound of the formula(5) with benzenthiol and azobisisobutyronitrile as a radical initiator in an organic solvent to convert it into a trans form; continuous reaction of the reaction product with a compound of the formula(10) to obtain a compound of the formula(3); and reaction of the compound of the formula(3) with an acylated compound of the formula(8) and a silylated compound of the formula(9).
Abstract translation: 目的：提供从（顺式）-3-乙酰氧基丙基 - 头孢菌酸制备头孢菌素衍生物的较高产率的改进方法。 构成：制备式（1）的头孢菌素衍生物的改进方法包括以下步骤：将式（5）化合物与苯并二酚和偶氮二异丁腈作为自由基引发剂在有机溶剂中进行自由基反应，将其转化为 转变; 反应产物与式（10）化合物的连续反应，得到式（3）化合物; 和式（3）的化合物与式（8）的酰化化合物和式（9）的甲硅烷基化合物的反应。
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公开(公告)号：KR101598329B1
公开(公告)日：2016-02-29
申请号：KR1020130029876
申请日：2013-03-20
Applicant: 일동홀딩스(주)
IPC: C12P19/04 , C08B37/08 , A61K31/728
CPC classification number: C08B37/0072 , A61K31/728 , A61L27/20 , A61L27/58 , A61L31/042 , A61L31/148 , C08L5/08 , C12P19/26 , C12R1/46
Abstract: 본발명은체내저분해속도를갖는히알루론산의제조방법및 상기방법으로제조된히알루론산을포함하는유착방지용조성물에대한것으로, 더욱상세하게는스트렙토코커스디스갈락티애 ID9103 균주(KCTC11818BP)를탄소원및 질소원이포함하는배지에서배양하는단계를포함하는체내저분해속도를가지는히알루론산의제조방법및 상기방법으로제조된히알루론산을포함하는유착방지용조성물을제공한다. 본발명의제조방법으로제조된히알루론산은 400만 Da 내지 1000만 Da의고분자히알루론산으로, 체내분해속도가느려유착방지효과가탁월하다. 본발명의제조방법으로제조된히알루론산을포함하는본 발명의유착방지용조성물은가교하지않은히알루론산을사용하므로써, 기존의가교제및 화합물을포함하는유착방지용조성물이가진문제점및 기존의히알루론산이가진문제점을개선할수 있다.
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公开(公告)号：KR1020140052306A
公开(公告)日：2014-05-07
申请号：KR1020120118279
申请日：2012-10-24
Applicant: 일동홀딩스(주)
IPC: C07D207/18 , C07D207/14 , A61K31/40 , A61P31/04
Abstract: The present invention relates to a novel peptide deformylase (PDF) inhibitor having an excellent antibacterial activity or a pharmaceutically acceptable salt thereof, a method for manufacturing the same, and a pharmaceutical composition comprising the same as an active ingredient.
Abstract translation: 本发明涉及具有优异的抗菌活性的新型肽脱甲酰基酶（PDF）抑制剂或其药学上可接受的盐，其制备方法和包含该肽的活性成分的药物组合物。
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公开(公告)号：KR1020130143229A
公开(公告)日：2013-12-31
申请号：KR1020120066576
申请日：2012-06-21
Applicant: 일동홀딩스(주)
Abstract: The present invention relates to a method for preparing tynadallized lactbacillus acidophilus dead cell raw material which is stable without browning at the time of preparation thereof, by establishing optimum conditions for removing the browning of the raw material, caused by caramel sugar and pigments generated when the raw material are prepared, and employing a method of removing glucoprotein, which is a byproduct of the Maillard reaction and generated in the tynadallized procedure. According to the present invention, the production of a material having antibiotic activity and harmful bacteria inhibitory activity is minimized by developing and introducing a two-stage tynadallization process of tynadallization at normal pressure and tynadallization through reduced-pressure concentration. According to the method developed through the present invention, reasons for the browning are removed during the preparing procedure, thereby fundamentally preparing a tynadallized lactobacillus acidophilus dead cell raw material, which is stable without browning during the storage thereof. Further, the preparing method according to the present invention is efficiently performed and thus is useful in the industry, by unifying the existing dual drying method of drying fermentation filtrate and tynadallized bacteria, respectively, before pulverization and mixing.
Abstract translation: 本发明涉及一种制备嗜酸乳杆菌嗜酸乳杆菌死细胞原料的方法，其在制备时无褐变，通过确定最佳条件来除去焦糖和由此产生的颜料引起的颜料的最佳条件 制备原料，并采用除去作为美拉德反应的副产物的糖蛋白的方法，并且在该方法中产生。 根据本发明，通过在常压下开发和引入二级叔戊酸化过程并通过减压浓缩进行tynadallization，使具有抗生素活性和有害细菌抑制活性的材料的生产被最小化。 根据本发明开发的方法，在制备过程中除去褐变的原因，从而从根本上制备了在储存期间稳定而不褐变的嗜酸乳杆菌嗜酸乳杆菌死细胞原料。 此外，通过在粉碎和混合之前分别干燥发酵滤液和硫酸化细菌的现有双干燥方法，有效地进行了本发明的制备方法，从而在工业中是有用的。
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Patent Agency Ranking
公开(公告)号：KR101266224B1
公开(公告)日：2013-05-21
申请号：KR1020100086001
申请日：2010-09-02
Applicant: 일동홀딩스(주)
IPC: C07D405/14 , B01J31/02
Abstract: 본발명은올메사르탄메독소밀의주요중간체인 (5-메틸-2-옥소-1,3-다이옥솔-4-일)메틸 4-(2-하이드록시프로판-2-일)-2-프로필-1-((2‘(1-트리틸-1H-테트라졸-5-일)바이페닐-4-일)메틸)-1H-이미다졸-5-카르복실레이트(이하트리틸올메사르탄메독소밀)의제조방법에관한것이다. 본발명은톨루엔, 자일렌또는아세톤용매에서하기화학식 3으로표시되는메독소밀클로라이드를요오드화알칼리금속, 18-crown-6 촉매, 무기염기성화합물의존재하에하기화학식 2로표시되는 4-(2-하이드록시프로판-2-일)-2-프로필-1((2‘-(1-트리틸-1H-테트라졸-5-일)바이페닐-4-일)메틸)-1H-이미다졸-5-카르복실릭에시드(이하트리틸올메사르탄)와 one-pot 반응시켜화학식 1로표시되는트리틸올메사르탄메독소밀을제조하는방법을제공한다.
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7.发明公开
公开(公告)号：KR1020130035808A
公开(公告)日：2013-04-09
申请号：KR1020110100364
申请日：2011-09-30
Applicant: 일동홀딩스(주)
Abstract: PURPOSE: Streptococcus dysgalactiae ID9103 and a method for producing hyaluronic acid using the same are provided to effectively obtain high molecular hyaluronic acid by culturing in a medium containing a carbon source and a nitrogen source. CONSTITUTION: A Streptococcus dysgalactiae ID9103 has deposit number KCTC11818BP. A method for producing hyaluronic acid comprises a step of culturing the strain in a medium containing a carbon source and a nitrogen source. The carbon source is selected from the group consisting of glucose, fructose, lactose, maltose, galactose, glycerol, and a mixture thereof. The nitrogen source is selected from the group consisting of a yeast extract, casein peptone, casein acid lysate, casein enzyme lysate, Bacto peptone, casitone, neopeptone, and a mixture thereof.
Abstract translation: 目的：使用这种相同的乳链球菌ID9103和透明质酸的制备方法，通过在含有碳源和氮源的培养基中培养来有效地获得高分子透明质酸。 构成：致病性链球菌ID9103具有保藏号KCTC11818BP。 制备透明质酸的方法包括在含有碳源和氮源的培养基中培养菌株的步骤。 碳源选自葡萄糖，果糖，乳糖，麦芽糖，半乳糖，甘油及其混合物。 氮源选自酵母提取物，酪蛋白胨，酪蛋白酸裂解物，酪蛋白酶裂解物，细菌蛋白胨，casitone，新蛋白胨及其混合物。
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公开(公告)号：KR101244977B1
公开(公告)日：2013-03-19
申请号：KR1020090025883
申请日：2009-03-26
Applicant: 일동홀딩스(주)
Abstract: 본 발명은 혈전용해효소를 생산하는 바실루스 서브틸리스 IDCC 9204에 관한 것으로 보다 상세하게는 동맥경화의 원인인 혈전을 분해하는 27.7kDa의 세린 프로테아제를 생산하는 바실루스 서브틸리스 IDCC 9204를 제공하는 데 있다. 본 발명의 바실루스 서브틸리스 IDCC 9204는 고활성의 혈전용해효소 생산균주로서, 이 균주가 생산하는 혈전용해효소는 혈전 예방 및 혈행개선을 위한 기능성식품소재로 각종 건강기능식품등에 유용하게 사용될 수 있다.
혈전용해효소, 나토키나제, 바실루스 서브틸리스-
9.发明授权
公开(公告)号：KR101205570B1
公开(公告)日：2012-11-27
申请号：KR1020110053314
申请日：2011-06-02
Applicant: 일동홀딩스(주)
IPC: C07D403/04 , C07D235/20 , A61K31/4184 , A61P9/12
Abstract: PURPOSE: A method for preparing 2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)-1H-benzimidazole is provided to obtain a large amount of the compound. CONSTITUTION: A method for preparing 2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)-1H-benzimidazole(compound 1) comprises: a step of reacting N-methyl-O-phenylene-diamine(3) and 2-n-propyl-4-methyl-1H-benzimidazole-6-carboxylic acid(2) using phosphorous oxychloride in a non-polar solvent at 100-110 Deg. C. for 5-15 hours. The non-polar solvent is xylene, 1,4-dioxane, or toluene. The compound is crystallized using non-aqueous organic solvent such as ethyl acetate or isopropyl acetate.
Abstract translation: 目的：提供2-正丙基-4-甲基-6-（1-甲基苯并咪唑-2-基）-1H-苯并咪唑的制备方法，得到大量的化合物。 构成：2-正丙基-4-甲基-6-（1-甲基苯并咪唑-2-基）-1H-苯并咪唑（化合物1）的制备方法包括：使N-甲基-O-亚苯基二胺 （3）和2-正丙基-4-甲基-1H-苯并咪唑-6-羧酸（2），使用磷酰氯在非极性溶剂中在100-110度下进行。 C. 5-15小时。 非极性溶剂是二甲苯，1,4-二恶烷或甲苯。 该化合物使用非水有机溶剂如乙酸乙酯或乙酸异丙酯结晶。
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10.发明授权치매, 치매관련 질환의 예방/치료 및 인지기능장애 개선에 효과가 있는 유산균 발효 산물, 이의 제조방법 및 용도 有权有效预防和治疗痴呆，痴呆相关疾病和改善认知障碍的乳酸菌发酵产品及其制备方法及用途
公开(公告)号：KR101087972B1
公开(公告)日：2011-12-01
申请号：KR1020090113998
申请日：2009-11-24
Applicant: 일동홀딩스(주)
IPC: A61K35/744 , A23L1/30 , C12N1/20
Abstract: 본 발명은 치매, 치매관련 질환의 예방/치료 및 인지기능장애 개선에 효과가 있는 유산균 발효 산물, 이의 제조방법 및 용도에 관한 것으로 보다 상세하게는 밀크 포함 배지에 유산균을 배양, 발효하여 얻은 유산균 발효물, 이의 제조방법 및 이를 유효성분으로 포함하는 치매 또는 인지기능 장애 예방 및 치료용 조성물에 관한 것이다. 본 발명은 밀크 포함 배지에서 유산균을 배양, 발효시켜 얻은 유산균 발효물, 이의 제조방법 및 용도를 제공한다. 상기 발효물은 Aβ의 생성을 유도하는 아밀로이드 생성과정의 β-세크리타제 활성을 억제함으로써 APPβ의 생성을 선택적으로 저해하는 활성성분이 포함되어 있어 치매, 치매관련 질환 예방 및 치료 또는 인지기능 개선이나 인지기능 장애의 예방 및 치료의 목적으로 유용하게 사용할 수 있다.
치매, 알츠하이머병, β-세크리타제, 유산균, 인지기능
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