公开(公告)号：WO2011112566A3

公开(公告)日：2011-10-27

申请号：PCT/US2011027521

申请日：2011-03-08

Applicant: ABBOTT LAB ,  HSIEH CHUNG-MING ,  BARLOW EVE H ,  KINGSBURY GILLIAN ANN ,  REILLY EDWARD B ,  MORGAN-LAPPE SUSAN ,  KARAOGLU HANZATIAN DENISE D ,  BUCHANAN FRITZ G ,  LI YINGCHUN

Inventor： HSIEH CHUNG-MING ,  BARLOW EVE H ,  KINGSBURY GILLIAN ANN ,  REILLY EDWARD B ,  MORGAN-LAPPE SUSAN ,  KARAOGLU HANZATIAN DENISE D ,  BUCHANAN FRITZ G ,  LI YINGCHUN

IPC: C07K16/28 ,  C12P21/08

CPC classification number: C07K16/2803 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92

Abstract: Isolated binding proteins, e.g., antibodies, which bind to Basigin (BSG), e.g., human BSG2, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.

Abstract translation: 公开了结合Basigin（BSG）（例如人BSG2）的分离的结合蛋白，例如抗体，以及相关的基于抗体的组合物和分子。 还公开了包含抗体的药物组合物，以及使用该抗体的治疗和诊断方法。

公开(公告)号：WO2012024650A3

公开(公告)日：2012-05-31

申请号：PCT/US2011048518

申请日：2011-08-19

Applicant: ABBOTT LAB ,  LACY SUSAN E ,  BARBON JEFFREY A ,  CHHAYA MEHA ,  FUNG EMMA ,  HUTCHINS CHARLES W ,  LANG DIANE M ,  BARLOW EVE H ,  LEDDY MARY ,  CHARI RAVI

Inventor： LACY SUSAN E ,  BARBON JEFFREY A ,  CHHAYA MEHA ,  FUNG EMMA ,  HUTCHINS CHARLES W ,  LANG DIANE M ,  BARLOW EVE H ,  LEDDY MARY ,  CHARI RAVI

IPC: C07K16/22

CPC classification number: C07K16/22 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/626 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/566

Abstract: The present disclosure encompasses NGF binding proteins, specifically to antibodies that are chimeric, CDR grafted and caninized antibodies, and methods of making and uses thereof. The antibodies, or antibody portions, of the disclosure are useful for detecting NGF and for inhibiting NGF activity, e.g., in a mammal subject suffering from a disorder in which NGF activity is detrimental.

Abstract translation: 本公开内容涵盖NGF结合蛋白，特别是嵌合抗体，CDR移植和可插入抗体的抗体及其制备及其用途的方法。 本公开的抗体或抗体部分可用于检测NGF和抑制NGF活性，例如在患有NGF活性有害的病症的哺乳动物受试者中。

公开(公告)号：WO2008064292A2

公开(公告)日：2008-05-29

申请号：PCT/US2007085349

申请日：2007-11-21

Applicant: ABBOTT LAB ,  MEZLER MARIO ,  MOELLER ACHIM ,  MUELLER REINHOLD ,  MUELLER BERNHARD K ,  GHAYUR TARIQ ,  BARLOW EVE H ,  SCHMIDT MARTIN ,  MEYER AXEL ,  TEUSCH NICOLE

Inventor： MEZLER MARIO ,  MOELLER ACHIM ,  MUELLER REINHOLD ,  MUELLER BERNHARD K ,  GHAYUR TARIQ ,  BARLOW EVE H ,  SCHMIDT MARTIN ,  MEYER AXEL ,  TEUSCH NICOLE

IPC: A61K39/395

CPC classification number: C07K16/28 ,  A61K39/3955 ,  A61K2039/505 ,  C07H21/00 ,  C07K16/2863 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.

Abstract translation: 本发明涉及结合Nogo-66受体的分离的蛋白质，特别是单克隆抗体。 具体地说，这些抗体具有抑制Nogo-66受体的天然配体结合并中和Nogo-66受体的能力。 本发明的这些抗体或其部分可用于检测NgR和抑制NgR活性，例如在患有NgR或Nogo-66活性有害的病症的人中。

公开(公告)号：EP2091563A4

公开(公告)日：2010-12-15

申请号：EP07854735

申请日：2007-11-21

Applicant: ABBOTT LAB

Inventor： MEZLER MARIO ,  MOELLER ACHIM ,  MUELLER REINHOLD ,  MUELLER BERNHARD K ,  GHAYUR TARIQ ,  BARLOW EVE H ,  SCHMIDT MARTIN ,  MEYER AXEL ,  TEUSCH NICOLE

IPC: A61K39/395

CPC classification number: C07K16/28 ,  A61K39/3955 ,  A61K2039/505 ,  C07H21/00 ,  C07K16/2863 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.

公开(公告)号：ES2609924T3

公开(公告)日：2017-04-25

申请号：ES07854735

申请日：2007-11-21

Applicant: ABBOTT LAB ,  ABBVIE DEUTSCHLAND

Inventor： MEZLER MARIO ,  MOELLER ACHIM ,  MUELLER REINHOLD ,  MUELLER BERNHARD K ,  GHAYUR TARIQ ,  BARLOW EVE H ,  SCHMIDT MARTIN ,  MEYER AXEL ,  TEUSCH NICOLE

IPC: C07K16/28

Abstract: Un anticuerpo monoclonal neutralizante aislado, o un fragmento de unión al antígeno del mismo, que interactúan específicamente al menos con un epítopo del receptor de Nogo-66, donde el anticuerpo monoclonal neutralizante aislado, o un fragmento de unión al antígeno del mismo , comprende una secuencia que comprende una región variable de cadena pesada (región VH) que comprende SEQ ID NO: 3 y una secuencia que comprende una región variable de cadena ligera (región VL) que comprende SEQ ID NO: 4, o una secuencia que comprende una región variable de cadena pesada (región VH) que comprende SEQ ID NO: 5 y una secuencia que comprende una región variable de cadena ligera (región VL) que comprende SEQ ID NO: 6.

公开(公告)号：CA2808577C

公开(公告)日：2018-09-25

申请号：CA2808577

申请日：2011-08-19

Applicant: ABBOTT LAB

Inventor： BARBON JEFFREY A ,  CHHAYA MEHA ,  FUNG EMMA ,  HUTCHINS CHARLES W ,  LANG DIANE M ,  BARLOW EVE H ,  LEDDY MARY ,  CHARI RAVI ,  LACY SUSAN E

IPC: C07K16/22

Abstract: The present disclosure encompasses NGF binding proteins, specifically to antibodies that are chimeric, CDR grafted and caninized antibodies, and methods of making and uses thereof. The antibodies, or antibody portions, of the disclosure are useful for detecting NGF and for inhibiting NGF activity, e.g., in a mammal subject suffering from a disorder in which NGF activity is detrimental.

公开(公告)号：GT201000249AA

公开(公告)日：2014-05-20

申请号：GT201000249

申请日：2012-12-17

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG

Inventor： MÜLLER BERNHARD K ,  SCHMIDT MARTIN ,  BARLOW EVE H ,  LEDDY MARY R ,  HSIEH CHUNGMING ,  BARDWELL PHILLIP D

IPC: A61K39/395 ,  C07K16/22

Abstract: LA PRESENTE INVENCIÓN SE REFIERE A PROTEÍNAS AISLADAS, PARTICULARMENTE ANTICUERPOS MONOCLONALES, QUE SE UNEN Y NEUTRALIZAN LA PROTEÍNA RGM A. ESPECÍFICAMENTE, ESTOS CUERPOS TIENEN LA CAPACIDAD DE INHIBIR LA UNIÓN DE RGM A A SU RECEPTOR Y/O SUS CORRECEPTORES. LOS ANTICUERPOS DE LA INVENCIÓN, O SUS PORCIONES, SON ÚTILES PARA DETECTAR RGM A E INHIBIR LA ACTIVIDAD DE RGM A, POR EJEMPLO EN UN SER HUMANO AFECTADO POR UN TRASTORNO QUE INCLUYE, NO TAXATIVAMENTE, ESCLEROSIS MÚLTIPLE, TRAUMATISMO CEREBRAL EN MAMÍFEROS, LESIONES EN LA MÉDULA ESPINAL, ACCIDENTE CEREBROVASCULAR, ENFERMEDADES NEURODEGENERATIVAS Y ESQUIZOFRENIA.

公开(公告)号：UY33274A

公开(公告)日：2011-09-30

申请号：UY33274

申请日：2011-03-11

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING ,  BARLOW EVE H ,  KINGSBURY GILLIAN ANN ,  REILLY EDWARD B ,  MORGAN-LAPPE SUSAN ,  HANZATIAN DENISE D KARAOGLU ,  BUCHANAN FRITZ G ,  YINGCHUN LI

IPC: A61K39/395 ,  A61P35/00 ,  C07K16/30 ,  C07K16/42 ,  C12N5/10 ,  C12N5/20 ,  C12N15/13 ,  C12N15/85 ,  C12P21/08

Abstract: Proteínas de unión aisladas, por ejemplo, anticuerpos, que se unen a la basigina (BSG), por ejemplo, la BSG2 humana, y composiciones y moléculas basadas en anticuerpos relacionadas. También se divulgan composiciones farmacéuticas que comprenden los anticuerpos, así como métodos terapéuticos y de diagnóstico para el uso de los anticuerpos.

公开(公告)号：CA2715456A1

公开(公告)日：2009-09-03

申请号：CA2715456

申请日：2009-02-27

Applicant: ABBOTT GMBH & CO KG ,  ABBOTT LAB

Inventor： MUELLER BERNHARD K ,  SCHMIDT MARTIN ,  BARLOW EVE H ,  LEDDY MARY R ,  HSIEH CHUNG-MING ,  BARDWELL PHILLIP D

IPC: C07K16/22 ,  A61K39/395

Abstract: The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but not limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.

公开(公告)号：BRPI0908012A2

公开(公告)日：2014-10-14

申请号：BRPI0908012

申请日：2009-02-27

Applicant: ABBOTT GMBH & CO KG ,  ABBOTT LAB

Inventor： MUELLER BERNHARD K ,  SCHMIDT MARTIN ,  BARLOW EVE H ,  LEDDY MARY R ,  HSIEH CHUNGMING ,  BARDWELL PHILIP D

IPC: C07K16/22 ,  A61K39/395

Abstract: The subject invention relates to monoclonal antibodies which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or antigen binding fragments thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but not limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.