公开(公告)号：BG110080A

公开(公告)日：2008-11-28

申请号：BG11008006

申请日：2006-09-20

Applicant: ABBOTT LAB

Inventor： BAUER JOHN ,  SALEKI-GERHARDT AZITA ,  NARAYANAN BIKSHANDARKOIL ,  CHEMBURKAR SANJAY ,  PATEL KETAN ,  SPIWEK HARRY ,  BAUER PHILIP ,  ALLEN KIMBERLY

IPC: C07D277/24 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

Abstract: The invention relates to (2S, 3S, 5S)-5-{N-(/N-methyl-N-[/2-isopropyl-4-thiasolyl/methyl]amino/carbonyl-L-valinyl)amino]-2-{N-[/5- thiazolyl/methoxycarbonyl]amino}-1,6-diphenyl-3-hydroxyhexan} (ritonavir), in particular to essentially pure crystalline ritonavir, to methods for obtaining it, and to pharmaceutical compositions containing it. The invention relates also to a method for obtaining an essentially pure crystalline polymorphous form II of ritonavir.

公开(公告)号：BG109682A

公开(公告)日：2007-03-30

申请号：BG10968206

申请日：2006-09-20

Applicant: ABBOTT LAB

Inventor： BAUER JOHN ,  SALEKI-GERHARDT AZITA ,  NARAYANAN BIKSHANDARKOIL ,  CHEMBURKAR SANJAY ,  PATEL KETAN ,  SPIWEK HARRY ,  BAUER PHILIP ,  ALLEN KIMBERLY

IPC: C07D277/24 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/00 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

Abstract: The invention relates to (2S,3S,5S)-5-{N-[N-(/N-methyl-N-[/2-isopropyl-4-thiazolyl/methyl]amino}carbonyl-L-valinyl)amino]-2-{N-[/5- thiazolyl/methoxycarbonyl]amino}-1,6-diphenyl-3-hydroxyhexane} (ritonavir), in particular to essentially pure amorphous ritonavir, to methods of obtaining it, to pharmaceutical compositions containing it, as well as to a method of obtaining essentially pure crystalline polymorphous forms I and II of ritonavir.

公开(公告)号：BG66140B1

公开(公告)日：2011-07-29

申请号：BG11008008

申请日：2008-03-12

Applicant: ABBOTT LAB

Inventor： BAUER JOHN ,  SALEKI-GERHARDT AZITA ,  NARAYANAN BIKSHANDARKOIL ,  CHEMBURKAR SANJAY ,  PATEL KETAN ,  SPIWEK HARRY ,  BAUER PHILIP ,  ALLEN KIMBERLY

IPC: C07D277/24 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

Abstract: Изобретениетосеотнасядоновакристалнаполимернаформана (2S,3S,5S)-5-(N - (N - ((N-метил- N - ( (2 - изопропил-4-тиазолил) метил) амино) карбонил)-L-валинил)амино)-2-(N - ((5-тиазолил) метоксикарбонил) амино)-1,6-дифенил-3-хидроксихексан, дометодизанеговотополучаване, дометодизаизползванетомукатофармацевтичносредствои дофармацевтичнисъстави, съдържащиноватакристалнаполиморфнаформа.

公开(公告)号：AR059764A2

公开(公告)日：2008-04-30

申请号：ARP070100929

申请日：2007-03-06

Applicant: ABBOTT LAB

Inventor： SPIWEK H ,  BAUER PHILIP ,  CHEMBURKAR S ,  NARAYANAN B ,  AZITA SALEKI ,  BAUER JOHN ,  ALLEN K ,  PATEL SUBHASH

IPC: A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

Abstract: Un proceso para preparar una composicion farmacéutica que comprende ritonavir, donde dicho proceso comprende el agregado de forma cristalina 2 de ritonavir a un recipiente y la conversion de dicho ritonavir e ingredientes adicionales dentro de dicho recipiente en dicha composicion farmacéutica y composicion farmacéutica que se obtiene.

公开(公告)号：BG65963B1

公开(公告)日：2010-07-30

申请号：BG10968206

申请日：2006-09-20

Applicant: ABBOTT LAB

Inventor： BAUER JOHN ,  SALEKI-GERHARDT AZITA ,  NARAYANAN BIKSHANDARKOIL ,  CHEMBURKAR SANJAY ,  PATEL KETAN ,  SPIWEK HARRY ,  BAUER PHILIP ,  ALLEN KIMBERLY

IPC: C07D277/24 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/00 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

Abstract: The invention relates to (2S,3S,5S)-5-{N-[N-(/N-methyl-N-[/2-isopropyl-4-thiazolyl/methyl]amino}carbonyl-L-valinyl)amino]-2-{N-[/5- thiazolyl/methoxycarbonyl]amino}-1,6-diphenyl-3-hydroxyhexane} (ritonavir), in particular to essentially pure amorphous ritonavir, to methods of obtaining it, to pharmaceutical compositions containing it, as well as to a method of obtaining essentially pure crystalline polymorphous forms I and II of ritonavir.

公开(公告)号：AR059763A2

公开(公告)日：2008-04-30

申请号：ARP070100928

申请日：2007-03-06

Applicant: ABBOTT LAB

Inventor： PATEL K ,  BAUER PHILIP ,  AZITA SALEKI ,  SPIWEK H ,  ALLEN K ,  NARAYANAN B ,  BAUER JOHN ,  CHEMBURKAR S

IPC: A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

Abstract: Proceso para la preparacion de la forma polimorfa cristalina 1 de ritonavir de una pureza mayor al 90%, que comprende la adicion de una solucion de la forma cristalina 2I de ritonavir a una pasta fluida de nucleos cristalinos de la forma polimorfa cristalina 1 de ritonavir en un contra solvente. Reivindicacion 1: Un proceso para la preparacion de la forma polimorfa cristalina 1 de ritonavir de una pureza mayor al 90%, caracterizado porque comprende la adicion de una solucion de la forma cristalina 2 de ritonavir a una pasta fluida de nucleos cristalinos de la forma polimorfa cristalina 1 de ritonavir en un contra solvente.

公开(公告)号：BG65150B1

公开(公告)日：2007-04-30

申请号：BG10519701

申请日：2001-01-30

Applicant: ABBOTT LAB

Inventor： BAUER JOHN ,  SALEKI-GERHARDT AZITA ,  NARAYANAN BIKSHANDARKOIL ,  CHEMBURKAR SANJAY ,  PATEL KETAN ,  SPIWEK HARRY ,  BAUER PHILIP ,  ALLEN KIMBERLY

IPC: A61K31/426 ,  A61K31/427 ,  A61P31/00 ,  A61P31/18 ,  A61P37/00 ,  A61P37/04 ,  C07D277/00 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

Abstract: The invention relates to a new crystalline polymorphic form of (2S,3S,5S)-5-{N-[N-(/N-methyl-N-[/2-isopropyl-4-thiazolyl/methyl]amino/carbonyl-L-valinyl)amino]-2-{N-/5-thiazolyl/methoxicarbonyl]amino}-1,6-diphenyl-3-xydroxyhexan} (ritonavir), to a method of obtaining it, and to pharmaceutical compositions containing it.