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    METHOD FOR USING A BLANK MATRIX IN A CONTINUOUS FORMAT HIGH THROUGHPUT SCREENING PROCESS
    2.
    发明申请
    METHOD FOR USING A BLANK MATRIX IN A CONTINUOUS FORMAT HIGH THROUGHPUT SCREENING PROCESS 审中-公开
    在连续格式高通量筛选过程中使用空白矩阵的方法

    公开(公告)号：WO2004027426A3

    公开(公告)日：2004-06-24

    申请号：PCT/US0328398

    申请日：2003-09-10

    Applicant: ABBOTT LAB

    Inventor： PAN JEFFREY Y ,  NEMCEK THOMAS A ,  GONZALEZ CARLOS ,  MASLANA EUGENE S ,  SABET REZA S ,  DONNELLY JENNIFER B ,  BURNS DAVID J ,  GROEBE DUNCAN R ,  WARRIOR USHA

    IPC: B01J19/00 ,  C40B40/10 ,  C40B60/14 ,  G01N33/543 ,  G01N33/559 ,  G01N33/549

    CPC classification number: G01N33/559 ,  B01J19/0046 ,  B01J2219/0036 ,  B01J2219/00364 ,  B01J2219/00382 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00725 ,  B01J2219/0074 ,  C40B40/10 ,  C40B60/14 ,  G01N33/5436 ,  G01N2500/00

    Abstract: A method for testing a multiplicity of chemical entities for the ability of these chemical entities to enhance or inhibit abiological process. In one embodiment, the method comprises the steps of: (a) providing a blank matrix having at least two major surfaces, the at least two major surfaces capable of receiving assay components and chemical entities; (b) applying at least one chemical entity to at least one of the at least two major surfaces of the blank matrix, whereby an impregnated matrix is formed; (c) applying to at least one of the at least two major surfaces ofthe impregnated matrix at least one assay component required for a biological process; and (d) evaluating the ability of the at least one chemical entity to enhance or inhibit the biological process involving the at least one assaycomponent. In the preferred embodiments, a response indicative of an enhancement or an inhibition of the aforementioned biological process can be detected by a tracer, which can be introduced to the impregnated matrix as an assay component. The response so detected can be preserved in the form of an image of the at least one of the two major surfaces of the impregnated matrix.

    Abstract translation: 一种用于测试这些化学实体增强或抑制生物过程能力的多种化学实体的方法。 在一个实施方案中，该方法包括以下步骤：（a）提供具有至少两个主表面的空白基质，所述至少两个主表面能够接收测定组分和化学实体; （b）将至少一个化学实体施加到所述空白基质的所述至少两个主表面中的至少一个上，由此形成浸渍的基质; （c）将浸渍基质的至少两个主要表面中的至少一个施加至生物过程所需的至少一种测定组分; 和（d）评估所述至少一个化学实体增强或抑制涉及所述至少一种测定组分的生物过程的能力。 在优选的实施方案中，可以通过示踪剂来检测指示上述生物过程的增强或抑制的反应，其可以作为测定组分引入到浸渍的基质中。 如此检测的响应可以以浸渍基质的两个主表面中的至少一个的图像的形式保存。

    Kontinuální systém vysoce výkonného screeningu s použitím planárních matric
    3.
    发明专利
    Kontinuální systém vysoce výkonného screeningu s použitím planárních matric 未知

    公开(公告)号：CZ299740B6

    公开(公告)日：2008-11-05

    申请号：CZ20002078

    申请日：1998-12-11

    Applicant: ABBOTT LAB

    Inventor： BEUTEL BRUCE A ,  SCHURDAK MARK E ,  VOORBACH MARTIN J ,  BURNS DAVID J ,  JOSEPH MARY K

    IPC: G01N33/48 ,  G01N33/543 ,  C07B63/00 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566 ,  G01N37/00

    Abstract: Zpusob soucasného testování množství vzorku ruzných látek na jejich zpusobilost zesilovat nebo inhibovat biologický proces, zahrnuje (g) uložení malého objemu každého z více než 96 vzorku rozdílnýchlátek v usporádání na matrici tak, že každá jednotlivá látka je soustredena na své vlastní odlišenémísto a identita každé látky muže být urcena z jejího místa uložení, (h) uvedení této matrice do styku s první porézní matricí obsahující nebo nesoucí rovnomerne rozptýlené zkušební cinidlo a umožnení, aby cást z každé látky difundovala do uvedené porézní matrice takovým zpusobem, že prostorové umístení každé difundované látky muže být korelováno s místem na uvedené matrici, na kterém byla uvedená látka puvodne uložena, a (i) provedení testu prostanovení zpusobilosti každé difundované látky zesilovat nebo inhibovat uvedený biologický proces pozorováním interakce každé látky s uvedeným zkušebním cinidlem, kde uvedenou matricí je planární matrice.

    EL ESCRUTINIO DE ALTO RENDIMIENTO EN FORMATO CONTINUO UTILIZANDO AL MENOS UNA MATRIZ POROSA.
    4.
    发明专利
    EL ESCRUTINIO DE ALTO RENDIMIENTO EN FORMATO CONTINUO UTILIZANDO AL MENOS UNA MATRIZ POROSA. 未知

    公开(公告)号：ES2270539T3

    公开(公告)日：2007-04-01

    申请号：ES98963130

    申请日：1998-12-11

    Applicant: ABBOTT LAB

    Inventor： BEUTEL BRUCE A ,  SCHURDAK MARK E ,  VOORBACH MARTIN J ,  BURNS DAVID J ,  JOSEPH MARY K

    IPC: G01N33/48 ,  G01N33/543 ,  C07B63/00 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566 ,  G01N37/00

    Abstract: Un procedimiento para ensayar simultáneamente una multitud de muestras de diferentes sustancias, por su capacidad para intensificar o inhibir un proceso biológico, comprendiendo: a) depositar en un array un pequeño volumen de cada una de más de 96 muestras de sustancias diferentes sobre una matriz, de manera que cada sustancia diferente esté centrada en su propio sitio diferente, y se pueda determinar la identidad de cada sustancia a partir de su sitio de deposición, b) poner en contacto dicha matriz con una primera matriz porosa conteniendo, o llevando, un primer reactivo de ensayo uniformemente dispersado, y dejar que algo de cada sustancia se difunda dentro de dicha matriz porosa de manera que la ubicación espacial de cada sustancia difundida pueda ser correlacionada con el sitio en dicha matriz en el que dicha sustancia fue originalmente depositada, y c) conducir un ensayo para determinar la capacidad de cada sustancia difundida para intensificar o inhibir dicho proceso biológico, observando la interacción de cada sustancia con dicho reactivo de ensayo, caracterizado por que dicha matriz es una matriz planar.

    METHOD FOR USING A BLANK MATRIX IN A CONTINUOUS FORMAT HIGH THROUGHPUT SCREENING PROCESS
    6.
    发明专利
    METHOD FOR USING A BLANK MATRIX IN A CONTINUOUS FORMAT HIGH THROUGHPUT SCREENING PROCESS 未知

    公开(公告)号：CA2498710A1

    公开(公告)日：2004-04-01

    申请号：CA2498710

    申请日：2003-09-10

    Applicant: ABBOTT LAB

    Inventor： MASLANA EUGENE S ,  GONZALEZ CARLOS ,  SABET REZA S ,  GROEBE DUNCAN R ,  NEMCEK THOMAS A ,  PAN JEFFREY Y ,  WARRIOR USHA ,  DONNELLY JENNIFER B ,  BURNS DAVID J

    IPC: B01J19/00 ,  C40B40/10 ,  C40B60/14 ,  G01N33/543 ,  G01N33/559 ,  G01N33/50 ,  C12Q1/34 ,  C12Q1/48

    Abstract: A method for testing a multiplicity of chemical entities for the ability of these chemical entities to enhance or inhibit abiological process. In one embodiment, the method comprises the steps of: (a) providing a blank matrix having at least two major surfaces, the at least two major surfaces capable of receiving assay components and chemical entities; (b) applying at least one chemical entity to at least one of the at least two major surfaces of the blank matrix, whereby an impregnated matrix is formed; (c) applying to at least one of the at least two major surfaces ofthe impregnated matrix at lea st one assay component required for a biological process; and (d) evaluating th e ability of the at least one chemical entity to enhance or inhibit the biological process involving the at least one assaycomponent. In the preferr ed embodiments, a response indicative of an enhancement or an inhibition of the aforementioned biological process can be detected by a tracer, which can be introduced to the impregnated matrix as an assay component. The response so detected can be preserved in the form of an image of the at least one of the two major surfaces of the impregnated matrix.

    Continuous format high throughput screening for testing compound for biological activity
    10.
    发明专利
    Continuous format high throughput screening for testing compound for biological activity 未知

    公开(公告)号：NZ504112A

    公开(公告)日：2002-11-26

    申请号：NZ50411298

    申请日：1998-12-11

    Applicant: ABBOTT LAB

    Inventor： SCHURDAK MARK E ,  BEUTEL BRUCE A ,  VOORBACH MARTIN J ,  BURNS DAVID J ,  JOSEPH MARY K

    IPC: G01N33/48 ,  C07B63/00 ,  G01N33/50 ,  G01N33/543 ,  G01N33/566 ,  G01N37/00

    Abstract: A process to simultaneously test a multitude of samples of different substances for their ability to enhance or inhibit a biological process comprising, a) depositing in an array a small volume of each of more than 96 samples of distinct substances onto a planar porous matrix containing or carrying a uniformly dispersed assay reagent such that each distinct substance is centered at its own distinct site and the identity of each substance can be determined from its deposition site, and b) observing the interaction of each substance with said assay reagent and correlating it to said substance's ability to enhance or inhibit said biological process. Continuous format high throughput screening (CF-HTS) using at least one porous matrix allows simultaneous screening of large numbers of chemical entities for a wide range of biological or biochemical activity, and CF-HTS is also useful to perform multi-step assays.

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