-
1.发明申请MUTANT PEPTIDES DERIVED FROM BAD AND THEIR USE TO IDENTIFY SUBSTANCES WHICH BIND TO A MEMBER OF THE BCL-2 FAMILY OF PROTEINS 审中-公开从BAD衍生的突变体及其用于识别BCL-2蛋白家族成员的物质
公开(公告)号：WO0220568A3
公开(公告)日：2002-09-26
申请号：PCT/US0127410
申请日：2001-09-04
Applicant: ABBOTT LAB
Inventor： FESIK STEPHEN W , MEADOWS ROBERT P , JOSEPH MARY K , OLEJNICZAK EDWARD T , PETROS ANDREW M , NETTESHEIM DAVID G , SWIFT KERRY M , MATAYOSHI EDMUND , ZHANG HAICHAO
CPC classification number: C07K14/4702
Abstract: The present invention relates to peptides derived from the wild-type human Bad peptide which bind to a member of the Bcl-2 family of proteins. The peptides of the present invention can be used in an assay to identify candidate substances which induce or promote apoptosis in cells.
Abstract translation: 本发明涉及衍生自与蛋白质Bcl-2家族成员结合的野生型人Bad肽的肽。 本发明的肽可用于测定诱导或促进细胞凋亡的候选物质。
-
公开(公告)号：WO9930154A3
公开(公告)日：1999-08-12
申请号：PCT/US9826465
申请日：1998-12-11
Applicant: ABBOTT LAB
Inventor： BEUTEL BRUCE A , SCHURDAK MARK E , VOORBACH MARTIN J , BURNS DAVID J , JOSEPH MARY K
IPC: G01N33/48 , C07B63/00 , G01N33/50 , G01N33/543 , G01N33/566 , G01N37/00 , G01N33/53
CPC classification number: G01N33/54313 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00614 , B01J2219/0063 , B01J2219/00641 , B01J2219/00659 , B01J2219/00707
Abstract: Continuous format high throughput screening (CF-HTS) using at least one porous matrix allows the pharmaceutical industry to simultaneously screen large numbers of chemical entities for a wide range of biological or biochemical activity. In addition, CF-HTS is useful to perform multi-step assays.
Abstract translation: 使用至少一个多孔基质的连续格式高通量筛选（CF-HTS）允许制药工业同时筛选大量化学实体用于广泛的生物或生化活性。 此外，CF-HTS可用于进行多步测定。
-
公开(公告)号：CZ299740B6
公开(公告)日：2008-11-05
申请号：CZ20002078
申请日：1998-12-11
Applicant: ABBOTT LAB
Inventor： BEUTEL BRUCE A , SCHURDAK MARK E , VOORBACH MARTIN J , BURNS DAVID J , JOSEPH MARY K
IPC: G01N33/48 , G01N33/543 , C07B63/00 , G01N33/50 , G01N33/53 , G01N33/566 , G01N37/00
Abstract: Zpusob soucasného testování množství vzorku ruzných látek na jejich zpusobilost zesilovat nebo inhibovat biologický proces, zahrnuje (g) uložení malého objemu každého z více než 96 vzorku rozdílnýchlátek v usporádání na matrici tak, že každá jednotlivá látka je soustredena na své vlastní odlišenémísto a identita každé látky muže být urcena z jejího místa uložení, (h) uvedení této matrice do styku s první porézní matricí obsahující nebo nesoucí rovnomerne rozptýlené zkušební cinidlo a umožnení, aby cást z každé látky difundovala do uvedené porézní matrice takovým zpusobem, že prostorové umístení každé difundované látky muže být korelováno s místem na uvedené matrici, na kterém byla uvedená látka puvodne uložena, a (i) provedení testu prostanovení zpusobilosti každé difundované látky zesilovat nebo inhibovat uvedený biologický proces pozorováním interakce každé látky s uvedeným zkušebním cinidlem, kde uvedenou matricí je planární matrice.
-
4.发明专利
公开(公告)号：ES2270539T3
公开(公告)日：2007-04-01
申请号：ES98963130
申请日：1998-12-11
Applicant: ABBOTT LAB
Inventor： BEUTEL BRUCE A , SCHURDAK MARK E , VOORBACH MARTIN J , BURNS DAVID J , JOSEPH MARY K
IPC: G01N33/48 , G01N33/543 , C07B63/00 , G01N33/50 , G01N33/53 , G01N33/566 , G01N37/00
Abstract: Un procedimiento para ensayar simultáneamente una multitud de muestras de diferentes sustancias, por su capacidad para intensificar o inhibir un proceso biológico, comprendiendo: a) depositar en un array un pequeño volumen de cada una de más de 96 muestras de sustancias diferentes sobre una matriz, de manera que cada sustancia diferente esté centrada en su propio sitio diferente, y se pueda determinar la identidad de cada sustancia a partir de su sitio de deposición, b) poner en contacto dicha matriz con una primera matriz porosa conteniendo, o llevando, un primer reactivo de ensayo uniformemente dispersado, y dejar que algo de cada sustancia se difunda dentro de dicha matriz porosa de manera que la ubicación espacial de cada sustancia difundida pueda ser correlacionada con el sitio en dicha matriz en el que dicha sustancia fue originalmente depositada, y c) conducir un ensayo para determinar la capacidad de cada sustancia difundida para intensificar o inhibir dicho proceso biológico, observando la interacción de cada sustancia con dicho reactivo de ensayo, caracterizado por que dicha matriz es una matriz planar.
-
公开(公告)号：DK1038179T3
公开(公告)日：2006-11-20
申请号：DK98963130
申请日：1998-12-11
Applicant: ABBOTT LAB
Inventor： BEUTEL BRUCE A , SCHURDAK MARK E , VOORBACH MARTIN J , BURNS DAVID J , JOSEPH MARY K
IPC: G01N33/48 , G01N33/543 , C07B63/00 , G01N33/50 , G01N33/53 , G01N33/566 , G01N37/00
Abstract: Continuous format high throughput screening (CF-HTS) using at least one porous matrix allows the pharmaceutical industry to simultaneously screen large numbers of chemical entities for a wide range of biological or biochemical activity. In addition, CF-HTS is useful to perform multi-step assays.
-
Patent Agency Ranking
公开(公告)号：PT1038179E
公开(公告)日：2006-12-29
申请号：PT98963130
申请日：1998-12-11
Applicant: ABBOTT LAB
Inventor： BEUTEL BRUCE A , SCHURDAK MARK E , VOORBACH MARTIN J , BURNS DAVID J , JOSEPH MARY K
IPC: G01N33/48 , G01N33/543 , C07B63/00 , G01N33/50 , G01N33/53 , G01N33/566 , G01N37/00
-
公开(公告)号：CA2310684A1
公开(公告)日：1999-06-17
申请号：CA2310684
申请日：1998-12-11
Applicant: ABBOTT LAB
Inventor： SCHURDAK MARK E , BEUTEL BRUCE A , JOSEPH MARY K , BURNS DAVID J , VOORBACH MARTIN J
IPC: G01N33/48 , C07B63/00 , G01N33/50 , G01N33/543 , G01N33/566 , G01N37/00 , G01N33/53
Abstract: Continuous format high throughput screening (CF-HTS) using at least one porous matrix allows the pharmaceutical industry to simultaneously screen large numbers of chemical entities for a wide range of biological or biochemical activity. In addition, CF-HTS is useful to perform multi-step assays.
-
公开(公告)号：CA2255909A1
公开(公告)日：1997-12-11
申请号：CA2255909
申请日：1997-06-03
Applicant: ABBOTT LAB
Inventor： SUBOTICH DANIEL T , MEES DAVID R , JOSEPH MARY K , POPE MARK R , PRY TERRY A , TARCHA PETER J , PUTMAN C BRENT
IPC: G01N33/543 , G01N33/547 , G01N33/545
Abstract: A method for increasing the binding activity of specific binding members bound to a solid phase material, e.g., a particle, that has been sterically stabilized. This increase in binding activity is brought about by degrading a steric stabilizer on the surface of the solid phase material. The method involves both immobilizing a specific binding member on the surface of a solid phase material and degrading a steric stabilizer on the surface of that solid phase material. In the preferred embodiment, the method involves the immobilization of a specific binding member on the surface of the sterically stabilized solid phase material, with subsequent degradation of the steric stabilizer.
-
公开(公告)号：HU228578B1
公开(公告)日：2013-04-29
申请号：HU0100207
申请日：1998-12-11
Applicant: ABBOTT LAB
Inventor： BEUTEL BRUCE A , SCHURDAK MARK E , VOORBACH MARTIN J , BURNS DAVID J , JOSEPH MARY K
IPC: G01N33/48 , G01N33/50 , C07B63/00 , G01N33/543 , G01N33/566 , G01N37/00
Abstract: Continuous format high throughput screening (CF-HTS) using at least one porous matrix allows the pharmaceutical industry to simultaneously screen large numbers of chemical entities for a wide range of biological or biochemical activity. In addition, CF-HTS is useful to perform multi-step assays.
-
公开(公告)号：PL194813B1
公开(公告)日：2007-07-31
申请号：PL34165598
申请日：1998-12-11
Applicant: ABBOTT LAB
Inventor： BEUTEL BRUCE A , SCHURDAK MARK E , VOORBACH MARTIN J , BURNS DAVID J , JOSEPH MARY K
IPC: G01N33/48 , G01N33/543 , C07B63/00 , G01N33/50 , G01N33/53 , G01N33/566 , G01N37/00
-
-
-
-
-
-
-
-
-
Search Results
29
records
(took 0.021 seconds)
