公开(公告)号：AU6199080A

公开(公告)日：1981-04-02

申请号：AU6199080

申请日：1980-09-03

Applicant: ABBOTT LAB

Inventor： MCALPINE J B ,  CARNEY R E

IPC: A61K31/35 ,  A61P31/04 ,  C07H15/224 ,  C07H15/22

Abstract: 1-Epi-2-deoxyfortimicin B and 4-N-derivatives thereof represented by the formula: wherein: R1 is hydrogen or loweralkyl and R2 is selected from the group consisting of loweralkyl, aminoloweralkyl, diaminoloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminoloweralkyl, acyl, aminoacyl, diaminoacyl, hydroxyacyl, hydroxy-substituted aminoacyl hydroxy-substituted diaminoacyl, N-loweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted-N-loweralkylaminoacyl or hydroxysubstituted N,N-diloweralkylaminoacyl with the limitation that R2 cannot be hydrogen glycyl, formylglycyl or hydantoyl, and the pharmaceutically acceptable salts thereof. The compounds are broad spectrum antibiotics.

公开(公告)号：AU511784B2

公开(公告)日：1980-09-04

申请号：AU2745377

申请日：1977-07-29

Applicant: ABBOTT LAB

Inventor： CARNEY R E ,  MCALPINE J B ,  PERUN T J

IPC: C07H15/236 ,  C07H15/22 ,  C07H15/26 ,  A61K31/71

Abstract: Described are novel derivatives of seldomycin factor 5 (XK-88-5) and particularly 3'-deoxyseldomycin factor 5, which exhibit improved activity against gram-positive and gram-negative bacteria resistant to aminoglycoside antibiotics, and a method of preparing them.