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公开(公告)号：WO9837180A3
公开(公告)日：1998-11-19
申请号：PCT/US9803367
申请日：1998-02-20
Applicant: ABBOTT LAB
Inventor： CHEN CHIH-MING , MOLLA AKHTERUZZAMAN , TRIPATHI RAKESH L
CPC classification number: C07K14/005 , A61K38/00 , C07K2319/00 , C12N9/506 , C12N2770/24222
Abstract: The present invention provides biologically active fusion proteins of hepatitis C virus NS3 protease and NS4A cofactor protein which are non-autocleavable and polynucleotides encoding same. Expression vectors comprising those polynucleotides and host cells transformed with those polynucleotides are also disclosed. The invention also provides a method for identifying inhibitor compounds of hepatitis C virus NS3 protease using the disclosed fusion proteins.
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