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公开(公告)号：WO9837180A3
公开(公告)日：1998-11-19
申请号：PCT/US9803367
申请日：1998-02-20
Applicant: ABBOTT LAB
Inventor： CHEN CHIH-MING , MOLLA AKHTERUZZAMAN , TRIPATHI RAKESH L
CPC classification number: C07K14/005 , A61K38/00 , C07K2319/00 , C12N9/506 , C12N2770/24222
Abstract: The present invention provides biologically active fusion proteins of hepatitis C virus NS3 protease and NS4A cofactor protein which are non-autocleavable and polynucleotides encoding same. Expression vectors comprising those polynucleotides and host cells transformed with those polynucleotides are also disclosed. The invention also provides a method for identifying inhibitor compounds of hepatitis C virus NS3 protease using the disclosed fusion proteins.
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公开(公告)号：WO2007081517A3
公开(公告)日：2007-12-21
申请号：PCT/US2006048685
申请日：2006-12-20
Applicant: ABBOTT LAB , BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
Inventor： BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
IPC: C07D495/04 , C07D471/04 , C07D513/04
CPC classification number: C07D487/04 , C07D471/04 , C07D475/06 , C07D495/04 , C07D513/04
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号：WO2007081517A8
公开(公告)日：2007-09-20
申请号：PCT/US2006048685
申请日：2006-12-20
Applicant: ABBOTT LAB , BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
Inventor： BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
IPC: C07D495/04 , C07D471/04 , C07D513/04
CPC classification number: C07D487/04 , C07D471/04 , C07D475/06 , C07D495/04 , C07D513/04
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
Abstract translation: 公开了有效抑制丙型肝炎病毒（“HCV”）或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物，这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药，用于合成这些化合物的方法和中间体，以及使用这些化合物治疗 HCV或其他病毒感染。
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公开(公告)号：WO2007076035A2
公开(公告)日：2007-07-05
申请号：PCT/US2006049080
申请日：2006-12-20
Applicant: ABBOTT LAB , ROCKWAY TODD W , BETEBENNER DAVID A , KRUEGER ALLAN C , IWASAKI NOBUHIKO , COOPER CURT S , ANDERSON DAVID D , KEMPF DALE J , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN
Inventor： ROCKWAY TODD W , BETEBENNER DAVID A , KRUEGER ALLAN C , IWASAKI NOBUHIKO , COOPER CURT S , ANDERSON DAVID D , KEMPF DALE J , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
Abstract translation: 公开了有效抑制丙型肝炎病毒（“HCV”）或其他病毒复制的化合物。 本发明还涉及包含此类化合物的组合物，此类化合物与其他抗病毒剂或治疗剂的共同配制或共同施用，用于合成此类化合物的方法和中间体，以及使用此类化合物治疗 HCV或其他病毒感染。
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公开(公告)号：WO2008133753A3
公开(公告)日：2008-12-24
申请号：PCT/US2007088027
申请日：2007-12-19
Applicant: ABBOTT LAB , BETEBENNER DAVID A , MARING CLARENCE J , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WENPING , LU LIANGJUN
Inventor： BETEBENNER DAVID A , MARING CLARENCE J , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WENPING , LU LIANGJUN
CPC classification number: C07D471/04 , C07D239/94 , C07D487/04 , C07D487/14 , C07D519/00
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ( HCV ) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, coformulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
Abstract translation: 公开了有效抑制丙型肝炎病毒（HCV）或其他病毒复制的化合物。 本发明还涉及包含此类化合物的组合物，这类化合物与其它抗病毒剂或治疗剂的共配制或共同施用，用于合成这些化合物的方法和中间体，以及使用此类化合物治疗HCV或 其他病毒感染。
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Patent Agency Ranking
公开(公告)号：WO2007076034A3
公开(公告)日：2007-10-04
申请号：PCT/US2006049079
申请日：2006-12-20
Applicant: ABBOTT LAB , BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
Inventor： BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D495/04 , C07D513/04
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号：EP2094276A4
公开(公告)日：2011-01-05
申请号：EP07874373
申请日：2007-12-19
Applicant: ABBOTT LAB
Inventor： BETEBENNER DAVID A , MARING CLARENCE J , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WENPING , LU LIANGJUN
IPC: A61K31/675 , C07D487/14
CPC classification number: C07D471/04 , C07D239/94 , C07D487/04 , C07D487/14 , C07D519/00
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公开(公告)号：HK1122291A1
公开(公告)日：2009-05-15
申请号：HK09101287
申请日：2009-02-11
Applicant: ABBOTT LAB
Inventor： BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
IPC: C07D20060101
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号：AT541844T
公开(公告)日：2012-02-15
申请号：AT06848055
申请日：2006-12-20
Applicant: ABBOTT LAB
Inventor： BETEBENNER DAVID , DEGOEY DAVID , MARING CLARENCE , KRUEGER ALLAN , IWASAKI NOBUHIKO , ROCKWAY TODD , COOPER CURT , ANDERSON DAVID , DONNER PAMELA , GREEN BRIAN , KEMPF DALE , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD , MOTTER CHRISTOPHER , PRATT JOHN , SHANLEY JASON , TUFANO MICHAEL , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI , MASSE SHERIE , CARRICK ROBERT , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID
IPC: C07D471/04
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号：CA2633760A1
公开(公告)日：2007-07-05
申请号：CA2633760
申请日：2006-12-20
Applicant: ABBOTT LAB
Inventor： TUFANO MICHAEL D , KRUEGER ALLAN C , SHANLEY JASON P , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , LU LIANGJUN , ANDERSON DAVID D , HE WEPING , MOLLA AKHTERUZZAMAN , ZHANG RONG , COOPER CURT S , IWASAKI NOBUHIKO , PILOT-MATIAS TAMI , MASSE SHERIE VL , BETEBENNER DAVID A , CARRICK ROBERT J , ROCKWAY TODD W , WAGNER ROLF , MO HONGMEI , KEMPF DALE J
IPC: C07D471/04
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (HCV) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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