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公开(公告)号：ZA201206552B
公开(公告)日：2013-05-29
申请号：ZA201206552
申请日：2012-08-31
Applicant: ABBOTT LAB
Inventor： LI YINGCHUN , MORGAN-LAPPE SUSAN , HSIEH CHUNG-MING , GU JIJIE JAMES , CHEN MING-JIU
IPC: C07K20060101
Abstract: DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.
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