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公开(公告)号：WO2011025964A3
公开(公告)日：2011-04-21
申请号：PCT/US2010047006
申请日：2010-08-27
Applicant: ABBOTT LAB , BENATUIL LORENZO , BOGHAERT ERWIN R , GU JIJIE , HARRIS MARIA , HICKSON JONATHAN A , HSIEH CHUNG-MING , KUTSKOVA YULIYA , LI YINGCHUN , LIU ZHIHONG , MORGAN-LAPPE SUSAN
Inventor： BENATUIL LORENZO , BOGHAERT ERWIN R , GU JIJIE , HARRIS MARIA , HICKSON JONATHAN A , HSIEH CHUNG-MING , KUTSKOVA YULIYA , LI YINGCHUN , LIU ZHIHONG , MORGAN-LAPPE SUSAN
IPC: C07K16/28
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/18 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.
Abstract translation: 描述了改进的DLL4结合蛋白，包括抗体，CDR-移植抗体，人抗体和DLL4结合片段，以高亲和力结合DLL4的蛋白质，以及中和DLL4活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤，特别是用于治疗或预防肿瘤血管生成和/或其它血管发生依赖性疾病，例如眼新生血管形成或以异常DLL4表达或活性为特征的血管发生非依赖性疾病，例如自身免疫 包括多发性硬化的疾病。
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公开(公告)号：WO2011109298A3
公开(公告)日：2011-11-24
申请号：PCT/US2011026489
申请日：2011-02-28
Applicant: ABBOTT LAB , LI YINGCHUN , GU JIJIE JAMES , MORGAN-LAPPE SUSAN , CHEN MINGJIU , HSIEH CHUNG-MING
Inventor： LI YINGCHUN , GU JIJIE JAMES , MORGAN-LAPPE SUSAN , CHEN MINGJIU , HSIEH CHUNG-MING
IPC: C07K16/18
CPC classification number: C07K16/28 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.
Abstract translation: 本文描述了DLL4结合蛋白，包括抗体，CDR-移植抗体，人源化抗体及其DLL4结合片段，以高亲和力结合DLL4的蛋白质，以及中和DLL4和/或VEGF活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤，特别是用于治疗或预防肿瘤血管生成。
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公开(公告)号：WO2011112566A3
公开(公告)日：2011-10-27
申请号：PCT/US2011027521
申请日：2011-03-08
Applicant: ABBOTT LAB , HSIEH CHUNG-MING , BARLOW EVE H , KINGSBURY GILLIAN ANN , REILLY EDWARD B , MORGAN-LAPPE SUSAN , KARAOGLU HANZATIAN DENISE D , BUCHANAN FRITZ G , LI YINGCHUN
Inventor： HSIEH CHUNG-MING , BARLOW EVE H , KINGSBURY GILLIAN ANN , REILLY EDWARD B , MORGAN-LAPPE SUSAN , KARAOGLU HANZATIAN DENISE D , BUCHANAN FRITZ G , LI YINGCHUN
CPC classification number: C07K16/2803 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92
Abstract: Isolated binding proteins, e.g., antibodies, which bind to Basigin (BSG), e.g., human BSG2, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
Abstract translation: 公开了结合Basigin（BSG）（例如人BSG2）的分离的结合蛋白，例如抗体，以及相关的基于抗体的组合物和分子。 还公开了包含抗体的药物组合物，以及使用该抗体的治疗和诊断方法。
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公开(公告)号：WO2011050262A3
公开(公告)日：2011-06-30
申请号：PCT/US2010053730
申请日：2010-10-22
Applicant: ABBOTT LAB , GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA , LIU ZHIHONG
Inventor： GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA , LIU ZHIHONG
IPC: C12P21/08
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K16/468 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：WO2009134776A3
公开(公告)日：2009-12-23
申请号：PCT/US2009041945
申请日：2009-04-28
Applicant: ABBOTT LAB , GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA
Inventor： GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA
IPC: A61K39/00
CPC classification number: C07K16/468 , A61K39/39533 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/565 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/6872 , G01N33/74 , G01N2333/515 , G01N2333/705 , Y10S435/81
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及它们在疾病的预防，诊断和/或治疗中的用途。
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Patent Agency Ranking
公开(公告)号：EP2282769A4
公开(公告)日：2012-04-25
申请号：EP09739578
申请日：2009-04-28
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA
CPC classification number: C07K16/468 , A61K39/39533 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/565 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/6872 , G01N33/74 , G01N2333/515 , G01N2333/705 , Y10S435/81
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：EP2491129A4
公开(公告)日：2013-05-29
申请号：EP10825739
申请日：2010-10-22
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA , LIU ZHIHONG
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K16/468 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：CL2012000980A1
公开(公告)日：2013-01-11
申请号：CL2012000980
申请日：2012-04-18
Applicant: ABBOTT LAB
Inventor： MORGAN-LAPPE SUSAN E , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANGS JIEVI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA , LIU ZHIHONG , GHAYUR TARIQ , REILLY EDWARD B
IPC: A61K39/395
Abstract: Proteina de unión que comprende una cadena de polipéptidos, en donde dicha cadena de polipéptidos comprende dos dominios variables de la cadena pesada y un dominio constante de la cadena pesada; conjugado de una proteína de unión que comprende dicha proteína; célula huesped, vector y ácido nucleico.
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公开(公告)号：CO6541599A2
公开(公告)日：2012-10-16
申请号：CO12079711
申请日：2012-05-15
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , LIU ZHIHONG , YING HUA , LIU JUNJIAN , LI YINGCHUN , NORVELL SUZANNE M , BELL RANDY , WANG JIEYI , PHILLIPS ANDREW , KING-SBURY GILLIAN A , REILLY EDWARD B
IPC: C12P21/08
Abstract: Proteínas de unión multivalentes y multiespecíficas diseñadas, métodos para elaborarlas y, específicamente, sus usos en la prevención, el diagnóstico y/o el tratamiento de enfermedades.
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公开(公告)号：CA2778176A1
公开(公告)日：2011-04-28
申请号：CA2778176
申请日：2010-10-22
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA , LIU ZHIHONG
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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